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JCI online early table of contents: Sept. 12, 2011
Date:9/12/2011

latent infection and found that they promoted the activation of immune cells known as CD4+ T cells reactive toward M. tuberculosis. These data provide new understanding of events during the late phase of infection and could help us begin to better understand and treat latent M. tuberculosis infections.

TITLE: Inflammatory dendritic cells migrate in and out of transplanted chronic mycobacterial granulomas in mice

AUTHOR CONTACT:
Matyas Sandor
University of Wisconsin, Madison, Wisconsin, USA.
Phone: 608.265.8715; Fax: 608.262.0846; E-mail: msandor@wisc.edu.

View this article at: http://www.jci.org/articles/view/45113?key=650e45f0554a30cdffd2


INFECTIOUS DISEASE: Recapitulating in vivo cellular function in vitro

It is estimated that one-third of the world's population is infected with the bacterium that causes tuberculosis, Mycobacterium tuberculosis. Upon infection, M. tuberculosis often hides in immune cells known as macrophages. Although the macrophages are somehow unable to kill off the invading bacteria, they do not allow the M. tuberculosis to grow. How macrophages restrict the growth of M. tuberculosis has not been determined. This is largely because the macrophages used thus far in in vitro studies fail to recapitulate what happens in vivo they support the growth of infecting M. tuberculosis and then die. However, Guillaume Vogt and Carl Nathan, at Weill Cornell Medical College, New York, have now developed a culture method that generates human macrophages that can survive infection with M. tuberculosis and that severely limit the growth of the bacteria. Vogt and Nathan hope that their new culture method will allow researchers to determine how macrophages keep M. tuberculosis under control.

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