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JCI online early table of contents: Sept. 12, 2011
Date:9/12/2011

the tumor known as MDCs produced a substance (peroxynitrite) that prevented the formation of the MHC/protein fragment complexes that CTLs recognize and that this rendered the tumor cells resistant to killing by CTLs. The clinical relevance of these data was highlighted by the observation that MDCs are a predominant source of peroxynitrite in human lung, pancreatic, and breast cancer samples. The authors therefore suggest that inhibitors of peroxynitrite production might improve the effectiveness of anticancer approaches designed to induce CTL responses.

TITLE: Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice

AUTHOR CONTACT:
Dmitry Gabrilovich
H. Lee Moffitt Cancer Center, Tampa, Florida, USA.
Phone: 813.745.6863; Fax: 813.745.1328; E-mail: dmitry.gabrilovich@moffitt.org.

View this article at: http://www.jci.org/articles/view/45862?key=47083e937e4f504f5fa3


INFECTIOUS DISEASE: The cellular comings and goings in contained M. tuberculosis infection

It is estimated that one-third of the world's population is infected with the bacterium that causes tuberculosis, Mycobacterium tuberculosis. However, only 5󈝶% of those infected develop active disease. In the majority of individuals, the bacteria are prevented from causing disease by being retained inside cell masses known as granulomas. Several cell types are found in granulomas, including immune cells known as inflammatory DCs. In new research, Matyas Sandor and colleagues, at the University of Wisconsin, Madison, have finally gained insight into the function of these cells in 'hidden' (latent) M. tuberculosis infection. Specifically, Sandor and colleagues were able to visualize inflammatory DCs trafficking in and out of granulomas in mice during
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Contact: Karen Honey
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Journal of Clinical Investigation
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