Navigation Links
JCI online early table of contents: Sept. 12, 2011
Date:9/12/2011

t British Columbia Cancer Agency Research Centre, Vancouver, has now identified an increase in the number of copies of the TRAF6 gene as a genetic change that can contribute to the development of human lung cancers. The team suggests that its data indicating that amplification of the TRAF6 gene is a common event in human lung cancers could explain why the signaling molecule NF-kappa-B is constitutively active in the majority of lung cancers.

TITLE: TRAF6 is an amplified oncogene bridging the RAS and NF-kappa-B pathways in human lung cancer

AUTHOR CONTACT:
Aly Karsan
British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada.
Phone: 604.675.8033; Fax: 604.675.8049; E-mail: akarsan@bccrc.ca.

View this article at: http://www.jci.org/articles/view/58818?key=f98695e6b1517c4b6a58


TUMOR IMMUNOLOGY: Understanding failure: why some anticancer therapies benefit only a few patients

For many years researchers sought to develop approaches to enhance the natural immune response to tumors in the hope that this would be clinically beneficial. As such, there are now several different ways to effectively direct immune responses toward tumor cells. However, surprisingly few patients have benefitted clinically from these approaches. A team of researchers, led by Dmitry Gabrilovich, at the H. Lee Moffitt Cancer Center, Tampa, has now identified one possible explanation as to why therapeutic approaches that induce responses mediated by immune cells known as cytotoxic T lymphocytes (CTLs) are not effective.

For CTLs to kill a cancer cell they must recognize on the cell's surface a protein complex known as an MHC molecule bound to a fragment of a cancer cellspecific protein. In the study, Gabrilovitch and colleagues found that in a mouse model of cancer, cells in
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
2. Web Content Management Enables Government Transparency, Participation, and Collaboration Online
3. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. Pharmahelper Pleased To Recognize Online Pharmacy Practice Standards Announced By Google Adwords
6. Online Dating Reinvents Itself with the Recent Roll-Out of Teacherhookup.com, a Free Website that Focuses on a Person's Career in Education!
7. EdenHome.com Adds Aventura Organic Clothes to Site and Announces Largest Online Selection of Stylish Organic Clothes for Men, Women and Children
8. Fire Protection Online Resolves Safety Concerns with CO2 Fire Extinguishers
9. JCI online early table of contents: Feb. 15, 2010
10. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
11. New Online Store Makes Buying Cosmetics a Healthy Choice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... (PRWEB) August 20, 2014 The Board ... Perkins Eastman is pleased to announce the ... services in China and the surrounding region. ... Richard Sprow AIA has relocated to the ... career in healthcare planning and design and to better ...
(Date:8/20/2014)... persistent and deadliest infectious diseases in the world, killing ... who study tuberculosis have long debated its origins. New ... Africa to seals and sea lions that brought the ... people there before Europeans landed on the continent. , ... Source of New World Human Tuberculosis," was published in ...
(Date:8/20/2014)... Sockeye salmon that sprint to spawning grounds through fast-moving ... University of British Columbia scientists. , When salmon encounter ... downstream of dams they must move upstream using ... to sprinting for humans. , "Days after sockeye passed ... dying only a short distance from their spawning grounds," ...
(Date:8/20/2014)... 2014 As concerns regarding the health ... ( http://www.injurybeacon.com/power-morcellator/ ) in gynecological surgery continue to ... from New York are urging the U.S. Food & ... devices. In a letter dated August 19th, Sens. Kirsten ... agency to seriously consider the testimony given during the ...
(Date:8/20/2014)... Research from Columbia University Medical Center shows that ... growth and that blocking nerve signals using surgery or ... disease. The study was conducted by the laboratory of ... MD, PhD, in Norway and is published in today,s ... have long observed that human and mouse cancers contain ...
Breaking Medicine News(10 mins):Health News:Perkins Eastman Expands Presence in China 2Health News:Perkins Eastman Expands Presence in China 3Health News:New research shows seals and sea lions likely spread tuberculosis to humans 2Health News:New research shows seals and sea lions likely spread tuberculosis to humans 3Health News:Salmon forced to 'sprint' less likely to survive migration 2Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 2Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 3Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 4Health News:Severing nerves may shrink stomach cancers: Botox injections slow growth of tumors in mice 2
... A visionary leader, Dr.,Maria Cristina Escobar Fritzsche ... contributions to the prevention and control of ... Pan American Sanitary Conference,proceedings today. The Abraham ... bestowed upon creative leaders whose commitment to,public ...
... LMAT ), a provider of peripheral vascular devices ... to launch a,direct sales force in Italy in January ... Italy through an,exclusive distribution agreement with Serom Medical Technologies ... rights on,January 25, 2008 in exchange for the payment ...
... - A cadre of private and public entities in ... National Adopting Changes to Improve Outcomes Now (ACTION) Campaign ... Campaign goals are to increase access to addiction treatment ... in treatment. , The campaign, launched during National ...
... APFC ), today announced that Chairman and Chief,Executive ... Operating,officer, Dr. Joseph Carleone, and Vice President and Chief ... the CIBC World Market,2nd Annual Industrials Conference, October 2-3, ... is available on the Company,s web site. About ...
... combined treatment with rapamycin and Gleevec might reverse the ... disease, according to the results of a new study ... of Hepatology, a journal published by John Wiley & ... Study of Liver Diseases (AASLD). The article is also ...
... This strategy beat out either therapy alone, researchers found ... combination of cognitive behavior therapy plus antidepressant drugs is ... thoughts and behavior in depressed teens, new research shows. ... October issue of the journal Archives of General ...
Cached Medicine News:Health News:Inter-American Leadership Award Bestowed Upon Chilean Chronic Disease Expert 2Health News:LeMaitre Vascular to Start Italian Sales Force 2Health News:LeMaitre Vascular to Start Italian Sales Force 3Health News:Leaders in addiction treatment announce national 'ACTION' campaign 2Health News:Combination therapy reverses effects of portal hypertension in rats 2Health News:Drug Plus Psychotherapy Best Treatment for Depressed Teens 2
(Date:8/20/2014)... LUTHERVILLE, Md. , Aug. 20, 2014 /PRNewswire/ ... today lauded the latest results achieved by the ... known as the National Precursor Log Exchange (NPLEx), ... enforcement officials track down methamphetamine offenders and make ... in Missouri blocked the ...
(Date:8/20/2014)... SOUTH PLAINFIELD, N.J. , Aug. 20, 2014 PTC ... it will participate at two upcoming investor conferences: ... Four Seasons Hotel in Boston on ... Annual Biotech Conference at The Mandarin Oriental Boston on Thursday, ... will present a company update at the Bank of America ...
(Date:8/20/2014)... 2014 Reportlinker.com announces that a new ... The Impact of Healthcare Reform (PPACA) ... http://www.reportlinker.com/p01618927/The-Impact-of-Healthcare-Reform-PPACA-On-the-US-IVD-Industry.html The "Patient Protection ... legislation that affects virtually every aspect of health ... to take effect now. IVD manufacturers who have ...
Breaking Medicine Technology:Missouri's Stop-Sale System Achieves Significant Results In Battle Against Meth 2PTC Therapeutics to Participate at Upcoming Investor Conferences 2The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 2The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 3The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 4The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 5The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 6
Long handle occluders are approximately 9 inches long....
Long handle occluders are approximately 9 inches long....
Basic external reading model....
Manual Lensmeter....
Medicine Products: