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JCI online early table of contents: Sept. 12, 2011
Date:9/12/2011

ee, USA.
Phone: 615.322.3642; Fax: 615.343.6229; E-mail: christopher.williams@vanderbilt.edu.

View this article at: http://www.jci.org/articles/view/44228?key=3aac564d108a38a35e37


NEPHROLOGY: Kidney maintains its integrity with the protein Arhgap24

A key function of our kidneys is to filter waste from our blood and to divert this into our urine. Focal segmental glomerulosclerosis (FSGS) is a kidney disease characterized by high levels of protein in the urine. It is caused by breakdown of the filtration barrier in the kidney that prevents proteins in the blood from being lost into the urine. A team of researchers, led by Andrey Shaw, at Washington University School of Medicine, St. Louis, has now linked a mutation in the ARHGAP24 gene to FSGS and uncovered the mechanism by which it could cause disease. The data lead the team to suggest that modulating the activity of the Arhgap24 protein could provide a new way to treat FSGS.

TITLE: Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis

AUTHOR CONTACT:
Andrey S. Shaw
Washington University School of Medicine, St. Louis, Missouri, USA.
Phone: 314.362.4614; Fax: 314.362.9108; E-mail: shaw@pathology.wustl.edu.

View this article at: http://www.jci.org/articles/view/46458?key=f0db4f3a9b1bb81cc4de


ONCOLOGY: New genetic link to lung cancers

Identifying the genetic changes that cause a cancer to form and progress is important for understanding the mechanisms underlying the cancer and for defining candidate therapeutic targets. A team of researchers, led by Aly Karsan, a
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