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JCI online early table of contents: Sept. 1, 2010
Date:9/1/2010

.jci.org/articles/view/42028?key=abc50d0de674281463f1">http://www.jci.org/articles/view/42028?key=abc50d0de674281463f1


AUTOIMMUNITY: Role for immune protein TLR8 in preventing autoimmunity

Key to the immune system responding to invading microbes is a group of proteins known as TLRs. These proteins trigger immune responses when they detect the presence of microbial products. Each TLR recognizes a distinct set of microbial products. As triggers of mouse TLR8 have not been identified, it has been suggested that it is inactive. However, a team of researchers, led by Lena Alexopoulou, at Centre d'Immunologie de Marseille-Luminy, France, has now determined that mouse TLR8 has a role in preventing the immune system attacking the body, that is, in preventing autoimmunity.

In the study, mice lacking TLR8 were found to have signs of the autoimmune disease lupus. This was associated with increased levels of TLR7 on immune cells known as dendritic cells and with increased responsiveness to molecules that trigger TLR7. The authors therefore conclude that mouse TLR8 has an important role in limiting TLR7 expression and that this is crucial for preventing the development of lupus-like autoimmunity.

TITLE: TLR8 deficiency leads to autoimmunity in mice

AUTHOR CONTACT:
Lena Alexopoulou
Centre d'Immunologie de Marseille-Luminy, Universit de la Mditerrane, Marseille, France.
Phone: 33.491.269199; Fax: 33.491.269430; E-mail: alexopoulou@ciml.univ-mrs.fr.

View this article at: http://www.jci.org/articles/view/42081?key=cb8bf48e147d2e5aa6ec


INFLAMMATION: The protein properdin complements inflammatory diseases

Inflammatory mediators such as the complement system that are key to host defense against microbes must be suppressed in th
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Journal of Clinical Investigation
Source:Eurekalert

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