Navigation Links
JCI online early table of contents: Sept. 1, 2010
Date:9/1/2010

ms of resistance might provide clues as to how to overcome this problem. A team of researchers, led by Steven de Jong, at the University of Groningen, The Netherlands, has now determined that high levels of expression of the protein p21 in the cytoplasm of tumor cells are a determinant of cisplatin-resistance in human testicular cancer cells known as testicular embryonal carcinoma cells. The team therefore suggests that targeting p21 in the cytoplasm might provide a way to treat testicular cancer that is resistant to platinum-based chemotherapeutics.

TITLE: Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer

AUTHOR CONTACT:
Steven de Jong
University Medical Center Groningen, Groningen, The Netherlands.
Phone: 31.0.50.3612964; Fax: 31.0.50.3614862; E-mail: s.de.jong@int.umcg.nl.

View this article at: http://www.jci.org/articles/view/41939?key=df301cc16f1792b9f7fa


METABOLIC DISEASE: Pacifying protein levels to treat diabetes

Individuals who have mutations in one of their two PDX1 genes are highly likely to develop diabetes. Understanding how levels of PDX1 are regulated is therefore of intense interest in the study and treatment of diabetes. A team of researchers, led by Doris Stoffers, at the University of Pennsylvania School of Medicine, Philadelphia, has now determined that the protein Pcif1 has a key role in regulating Pdx1 protein levels in mice. Specifically, Pcif1 was found to target Pdx1 for degradation. Interestingly, the signs of diabetes observed in mice lacking one Pdx1 gene were absent if one Pcif1 gene was also deleted, because Pdx1 protein levels became normalized. These data, which provide new insight into the regulation of Pdx1 protein levels, lead the authors to suggest that targeting PCIF1-mediated degradation o
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
2. Web Content Management Enables Government Transparency, Participation, and Collaboration Online
3. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. Pharmahelper Pleased To Recognize Online Pharmacy Practice Standards Announced By Google Adwords
6. Online Dating Reinvents Itself with the Recent Roll-Out of Teacherhookup.com, a Free Website that Focuses on a Person's Career in Education!
7. EdenHome.com Adds Aventura Organic Clothes to Site and Announces Largest Online Selection of Stylish Organic Clothes for Men, Women and Children
8. Fire Protection Online Resolves Safety Concerns with CO2 Fire Extinguishers
9. JCI online early table of contents: Feb. 15, 2010
10. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
11. New Online Store Makes Buying Cosmetics a Healthy Choice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... Oak Brook , ... Council and the March of Dimes invites nurses, midwives, nurse practitioners, ... the March of Dimes 34th Annual Perinatal Conference February 25-27th ... healthcare professionals caring for moms and babies are urged to attend. ...
... 23 Former presidential candidate Gary Bauer on Friday ... week in which President Obama issued an executive order ... innocent unborn children overseas. Gary Bauer, president of American ... awaiting news that President Obama had signed an executive ...
... N.Y., Jan. 23 Moog Inc. (NYSE: MOG.A; MOG.B) ... Ethox International for $15.2 million in cash. Ethox is ... provider. The company produces proprietary medical devices and ... of the industry,s leading medical device companies. Ethox also ...
... Ohio, Jan. 23 Heartland Information Services,( www.heartlandis.com ... of 12,ranked outsourced transcription companies in a report ... healthcare research firm,( www.KLASresearch.com ). In their report, ... Services for 2008, Heartland moved up for the ...
... Raise Money for HIV/AIDSLAS VEGAS, Jan. 23 Performers ... this Valentine,s Day to raise money for people with ... Annual Naked Hearts," presented by KRAVE Nightclub and staged ... Rainbow. This year,s bare-as-you-dare event takes place, appropriately enough, ...
... and Blue Shield,in Wisconsin announced today that its associates ... organizations in 2009 as part of,the company,s annual Associate ... Blue Shield will match 50 percent of associate pledges,increasing ... "Every day our associates work to ...
Cached Medicine News:Health News:March of Dimes 34th Annual Perinatal Conference For Nurses, Health Educators, Social Workers and Other Healthcare Pros Caring for Moms and Babies 2Health News:Moog Acquires Buffalo-Based Ethox International 2Health News:Moog Acquires Buffalo-Based Ethox International 3Health News:Moog Acquires Buffalo-Based Ethox International 4Health News:Heartland Information Services Moves Up to 2nd Place in National Survey for Outsourced Transcription 2Health News:Las Vegas Gets 'Naked' This Valentine's Day! 2Health News:Anthem Blue Cross and Blue Shield Associates Pledge More Than $900,000 to Community Organizations 2Health News:Anthem Blue Cross and Blue Shield Associates Pledge More Than $900,000 to Community Organizations 3
(Date:12/17/2014)... RALEIGH, N.C. , Dec. 17, 2014 ... and Integrated Clinical Trial Services, LLC (ICTS), two ... clinical trials announce that they have formed a ... (i-CTMS). i-CTMS will provide a broad range of ... and medical device companies. i-CTMS will ...
(Date:12/15/2014)... , Dec. 12, 2014 Research and Markets ... of the "Electrocardiogram (ECG) Devices - Global Trends, ... http://photos.prnewswire.com/prnh/20130307/600769 ... US$330 million by 2016. The North America ... global market share while Europe ...
(Date:12/15/2014)... Israel , Dec. 15, 2014  Immune ... announced today that its Board of Directors has elected Mr. ... Teper who continues as Chief Executive Officer of Immune. ... Directors since 2013. Immune,s new Chairman, Mr. ... interest of shareholders and to continue to support the strategic ...
Breaking Medicine Technology:Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 2Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 3Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 2Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 3Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 4Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 2Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 3Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 4
... Kaiser Permanente Hawaii has received the inaugural Pharmacy ... Permanente,s achievement of a 5-star rating on the PQA ... Centers for Medicare and Medicaid Services (CMS) Star Rating ... because it uses publicly available quality data from CMS," ...
... June 2, 2011 Mylan Inc. (Nasdaq: ... Inc. has received final approval from the U.S. Food ... Application (ANDA) for Venlafaxine Hydrochloride (HCl) Extended-release (ER) Capsules, ... (base), the generic version of Wyeth,s Effexor XR® Capsules, ...
Cached Medicine Technology:PQA Recognizes Kaiser Permanente Hawaii for Excellence in Medication Safety 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: