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JCI online early table of contents: Sept. 1, 2010
Date:9/1/2010

ms of resistance might provide clues as to how to overcome this problem. A team of researchers, led by Steven de Jong, at the University of Groningen, The Netherlands, has now determined that high levels of expression of the protein p21 in the cytoplasm of tumor cells are a determinant of cisplatin-resistance in human testicular cancer cells known as testicular embryonal carcinoma cells. The team therefore suggests that targeting p21 in the cytoplasm might provide a way to treat testicular cancer that is resistant to platinum-based chemotherapeutics.

TITLE: Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer

AUTHOR CONTACT:
Steven de Jong
University Medical Center Groningen, Groningen, The Netherlands.
Phone: 31.0.50.3612964; Fax: 31.0.50.3614862; E-mail: s.de.jong@int.umcg.nl.

View this article at: http://www.jci.org/articles/view/41939?key=df301cc16f1792b9f7fa


METABOLIC DISEASE: Pacifying protein levels to treat diabetes

Individuals who have mutations in one of their two PDX1 genes are highly likely to develop diabetes. Understanding how levels of PDX1 are regulated is therefore of intense interest in the study and treatment of diabetes. A team of researchers, led by Doris Stoffers, at the University of Pennsylvania School of Medicine, Philadelphia, has now determined that the protein Pcif1 has a key role in regulating Pdx1 protein levels in mice. Specifically, Pcif1 was found to target Pdx1 for degradation. Interestingly, the signs of diabetes observed in mice lacking one Pdx1 gene were absent if one Pcif1 gene was also deleted, because Pdx1 protein levels became normalized. These data, which provide new insight into the regulation of Pdx1 protein levels, lead the authors to suggest that targeting PCIF1-mediated degradation o
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Contact: Karen Honey
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Journal of Clinical Investigation
Source:Eurekalert

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