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JCI online early table of contents: Sept. 1, 2010
Date:9/1/2010

at provides protection from malaria in mice. The team hopes its approach to vaccine design will help in the future development of a malaria vaccine.

One way to design a malaria vaccine is to use a modified virus to deliver immune-stimulating malaria proteins to the body. Adenovirus is considered an ideal virus for this. However, adenovirus-based vaccines tend to induce only weak antibody-mediated immune responses and many individuals harbor immune molecules that neutralize the adenovirus delivery vehicle, thereby dampening immune responses to the proteins it carries. The authors modified an adenovirus carrying a malaria protein such that it also contained a fragment of a malaria protein that would induce a strong antibody immune response in place of the adenovirus protein that is most targeted by neutralizing immune responses. This modified adenovirus induced a substantially increased level of protection against malaria in mice, indicating that it is an improvement on the old adenovirus vaccine candidate.

TITLE: Replacing adenoviral vector HVR1 with a malaria B cell epitope improves immunogenicity and circumvents preexisting immunity to adenovirus in mice

AUTHOR CONTACT:
Moriya Tsuji
Aaron Diamond AIDS Research Center, New York, New York, USA.
Phone: 212.448.5021; Fax: 212.725.1126; E-mail: mtsuji@adarc.org.

View this article at: http://www.jci.org/articles/view/39812?key=ad717d6f517985a0f625


ONCOLOGY: Mechanisms of testicular cancer drug resistance

For many different types of cancer, including testicular cancer, platinum-based chemotherapeutic drugs such as cisplatin are the treatment of choice. Although such treatments are often effective, a sizeable fraction of patients eventually relapse with disease that is resistant to these drugs. Understanding the mechanis
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Contact: Karen Honey
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734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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