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JCI online early table of contents: Oct. 18, 2010

of CCL5 mRNA (the template from which CCL5 protein is made) in the liver were observed to be associated with severe disease.

TITLE: Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice

Hermann E. Wasmuth
University Hospital Aachen, Aachen, Germany.
Phone: 49.241.8080861; Fax: 49.241.8082455; E-mail:

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CARDIOVASCULAR DISEASE: Role for the protein S1PR2 in hardening of the arteries

One of the major causes of heart attack and stroke is atherosclerosis a disease of the major arterial blood vessels that is sometimes known as hardening of the arteries. New data, generated in mice, by a team of researchers led by Yoh Takuwa and Yasuo Okamoto, at Kanazawa University, Japan, indicates that the protein S1PR2 is important in the development of atherosclerosis, leading the team to suggest that it might provide a new therapeutic target for this prevalent condition. Of critical importance to this conclusion and suggestion was the observation that mice lacking both S1PR2 and ApoE developed less atherosclerotic disease when fed a high fat diet than did mice lacking ApoE but expressing S1PR2 normally.

TITLE: Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice

Yoh Takuwa
Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan.
Phone:; Fax:; E-mail:

Yasuo Okamoto
Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan.
Phone: 81.76

Contact: Karen Honey
Journal of Clinical Investigation

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