Navigation Links
JCI online early table of contents: Oct. 18, 2010
Date:10/18/2010

>Chronic kidney disease is the ninth leading cause of death in the United States. It is the term given to the progressive loss of kidney function over many months or years culminating in end-stage renal disease, which requires treatment with dialysis or a kidney transplant. A team of researchers, led by Katalin Susztak, at Albert Einstein College of Medicine, New York, has now generated new data, by analysis of a mouse model of chronic kidney disease and kidney samples from patients with the condition, that lead them to suggest that inhibiting activation of the Notch signaling pathway might provide a way to reduce progression to end-stage renal disease.

TITLE: Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

AUTHOR CONTACT:
Katalin Susztak
Albert Einstein College of Medicine, New York, New York, USA.
Phone: 718.430.3498; Fax: 718.430.8963; E-mail: katalin.susztak@einstein.yu.edu.

View this article at: http://www.jci.org/articles/view/43025?key=57c3da7d127adbe6b9ab


HEPATOLOGY: Ameliorating scarring of the liver

Chronic liver damage, such as that caused by chronic infection with hepatitis C virus or by chronic alcohol abuse, leads to scarring of the liver tissue (a condition also known as liver fibrosis) and ultimately end-stage liver disease. A team of researchers, led by Hermann Wasmuth, at University Hospital Aachen, Germany, has now found a way to ameliorate experimental liver fibrosis in mice. Specifically, the team found that an antagonist of the proteins to which the molecule Ccl5 binds ameliorated liver fibrosis in two mouse models of the condition and was able to accelerate fibrosis regression. These results are likely to have clinical implications because in patients with liver fibrosis, high levels
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
2. Web Content Management Enables Government Transparency, Participation, and Collaboration Online
3. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. Pharmahelper Pleased To Recognize Online Pharmacy Practice Standards Announced By Google Adwords
6. Online Dating Reinvents Itself with the Recent Roll-Out of Teacherhookup.com, a Free Website that Focuses on a Person's Career in Education!
7. EdenHome.com Adds Aventura Organic Clothes to Site and Announces Largest Online Selection of Stylish Organic Clothes for Men, Women and Children
8. Fire Protection Online Resolves Safety Concerns with CO2 Fire Extinguishers
9. JCI online early table of contents: Feb. 15, 2010
10. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
11. New Online Store Makes Buying Cosmetics a Healthy Choice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... 2014 Lunadress.co.uk, one of the world’s ... has recently released its fashionable white prom gowns. These ... quality and low price. The company provides a big ... and free shipping for orders over 99 pounds. , ... professional sales representatives if needed. The kind experts will ...
(Date:11/28/2014)... 2014 The report “Poxvirus Infections ... the therapeutic development for Poxvirus Infections, complete with ... drug target, mechanism of action (MoA), route of ... updates, and featured news and press releases. It ... development for Poxvirus Infections and special features on ...
(Date:11/28/2014)... Angelweddingdress.com, a world-famous dress manufacturer and retailer, has ... Styles of Bridesmaid Dresses recently. A big ... free shipping on orders over $150! Those who ... less at the online store please click ... reliable dress supplier in the international market. It ...
(Date:11/28/2014)... Yesterday on November 27th, 2014, Thanksgiving morning, ... and families from 8 different sites throughout Miami-Dade and ... in Florida on Thanksgiving Day. Over 1,400 volunteers worked ... together individual meals via assembly lines and passing them ... includes turkey, stuffing, green beans, mashed potatoes, cranberry sauce, ...
(Date:11/28/2014)... 2014 Pathways Home Health & ... This national movement was created to encourage people to ... local charities and causes. This online event, celebrated ... kickoff of the holiday shopping season. #GivingTuesday is to ... Cyber Monday is to online commerce. , The goal ...
Breaking Medicine News(10 mins):Health News:LunaDress.co.uk: New White LunaDress Prom Gowns Online for Sale Now 2Health News:Poxvirus Infections and Vestibular Diseases Pipeline Market Drugs and Companies Review H2 2014 2Health News:Poxvirus Infections and Vestibular Diseases Pipeline Market Drugs and Companies Review H2 2014 3Health News:Poxvirus Infections and Vestibular Diseases Pipeline Market Drugs and Companies Review H2 2014 4Health News:Blue Color Styles of Bridesmaid Dresses from AngelWeddingDress.com are Available Now With Big Discounts 2Health News:Branches’ 14th Annual Thanksgiving Delivers 6,000+ Meals to Families in Need 2Health News:Pathways Home Health & Hospice Joins #GivingTuesday; Annual Holiday Encourages Local Charitable Giving 2Health News:Pathways Home Health & Hospice Joins #GivingTuesday; Annual Holiday Encourages Local Charitable Giving 3
... HealthDay Reporter , MONDAY, March 5 (HealthDay News) -- The more ... big screen, the more alcohol they drink themselves, a new study ... 10 to 19 from six European countries -- the largest study ... or more drinks on at least one occasion. Teens who ...
... , MONDAY, March 5 (HealthDay News) -- Babies ... greater risk of developing asthma when compared with children born ... to infants born between the 34th and 37th week of ... an asthma diagnosis by the age of 8 years, despite ...
... available in French . A ... increase in prevalence of Canadian children diagnosed with attention-deficit ... associated with ADHD in school-age children. The study, ... Among Canadian Preschoolers and School-Age Children: 1994-2007, was conducted ...
... study from Case Western Reserve University,s Frances Payne Bolton ... related to quality of life before becoming critically ill. ... a research team that observed, taped and analyzed discussions ... intensive care units (ICUs) at University Hospitals Case Medical ...
... gene that causes adult-onset primary cervical dystonia, an often-painful condition ... team from the Jacksonville, Fla., campus of Mayo Clinic and ... a movement disorder that physicians previously could seldom explain. Their ... . In 1990, a man with a crooked neck ...
... University of Notre Dame,s annual Bengal Bouts student boxing ... Bodies May Be Nourished." The unusual mantra is ... benefit Holy Cross Missions in Bangladesh, part of the ... Dame,s founding religious community. However, this year a large ...
Cached Medicine News:Health News:Drinking Scenes in Movies May Spur Teens to Do the Same 2Health News:Drinking Scenes in Movies May Spur Teens to Do the Same 3Health News:Late Preemie Birth May Be Linked to Higher Asthma Risk 2Health News:Hyperactivity: Increased prevalence of children with ADHD and the use of stimulants 2Health News:CWRU study finds quality-of-life discussions are important for ICU patients 2Health News:Researchers ID gene behind primary cervical dystonia, a neck-twisting disorder 2Health News:Researchers ID gene behind primary cervical dystonia, a neck-twisting disorder 3Health News:Notre Dame's Bengal Bouts participants aid in concussion research 2Health News:Notre Dame's Bengal Bouts participants aid in concussion research 3
(Date:11/28/2014)... Aratana Therapeutics, Inc. (NASDAQ: PETX ), ... acquisition, development and commercialization of innovative biopharmaceutical products for ... it will present at the 26 th Annual ... 2014, at the New York Palace Hotel in ... St. Peter , M.D., President and Chief Executive Officer, ...
(Date:11/27/2014)... 27, 2014  Javon Bea Mercy Health System ... and staff at Janesville Craig High School and Janesville ... Health System physicians and Janesville ... and the Janesville School District. ... dedicated to providing schools and other organizations with the ...
(Date:11/26/2014)... , Nov. 26, 2014  Aethlon Medical, Inc. (OTCQB:AEMD), ... agreement to raise approximately $3.3 million at a price ... by one institutional healthcare focused investor. Each unit consists of ... common share purchase warrant. Each whole warrant entitles the ... of $0.30 for a period of five years from ...
Breaking Medicine Technology:Aratana Therapeutics to Present at the 26th Annual Piper Jaffray Healthcare Conference 2Mercy Health System, Janesville Police / Fire, provide casualty training to high school faculty 2Mercy Health System, Janesville Police / Fire, provide casualty training to high school faculty 3Aethlon Medical Announces $3.3 Million Equity Investment 2Aethlon Medical Announces $3.3 Million Equity Investment 3
Midstream Catch Kits...
... BladderScan® BVI 6100 is a handheld, noninvasive ... is easy to operate, so any staff ... To view ultrasound images from exams and ... records and reimbursement, just log on to ...
... the world's leading bulking therapy, is the ... of Stress Urinary Incontinence (SUI). Natural collagen ... to aid coaptation in a defective internal ... Contigen Bard Collagen Implant forms a soft ...
... Positionable Penile Prosthesis,The ... prosthesis is made of ... core strength that gives ... most: ease of positioning, ...
Medicine Products: