Navigation Links
JCI online early table of contents: Oct. 18, 2010
Date:10/18/2010

; E-mail: emorrise@mail.med.upenn.edu.

View this article at: http://www.jci.org/articles/view/44596?key=4304e5eea9ceffdf4e1b


HEMATOLOGY: Understanding treatment failure after bone marrow transplantation

Some forms of cancer are treated by transplantation with blood or bone marrow from a genetically non-identical individual (i.e., treated by allogeneic BMT). The idea behind this is that immune cells known as T cells, in particular CTLs, from the donor will attack and destroy the cancer. The main cause of treatment failure is tumor recurrence due to loss of functional donor CTLs that target the tumor. A team of researchers, led by Ronjon Chakraverty, at University College London, United Kingdom, has now identified two mechanisms by which loss of functional donor CTLs occurs in mouse models of allogeneic BMT. Furthermore, they identified a way to overcome one of these mechanisms disrupting interactions between the proteins PD-1 and PD-L1 such that donor CTL function was partially restored. They therefore suggest that these data define a potential approach to prevent or treat tumor recurrence following allogeneic BMT.

TITLE: Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation

AUTHOR CONTACT:
Ronjon Chakraverty
University College London, London, United Kingdom.
Phone: 44.207.317.7513; Fax: 44.207.830.2092; E-mail: r.chakraverty@medsch.ucl.ac.uk.

View this article at: http://www.jci.org/articles/view/41446?key=600b45fdb2c3f6f905ac


NEPHROLOGY: Slowing progression of chronic kidney disease

'/>"/>
Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
2. Web Content Management Enables Government Transparency, Participation, and Collaboration Online
3. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. Pharmahelper Pleased To Recognize Online Pharmacy Practice Standards Announced By Google Adwords
6. Online Dating Reinvents Itself with the Recent Roll-Out of Teacherhookup.com, a Free Website that Focuses on a Person's Career in Education!
7. EdenHome.com Adds Aventura Organic Clothes to Site and Announces Largest Online Selection of Stylish Organic Clothes for Men, Women and Children
8. Fire Protection Online Resolves Safety Concerns with CO2 Fire Extinguishers
9. JCI online early table of contents: Feb. 15, 2010
10. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
11. New Online Store Makes Buying Cosmetics a Healthy Choice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... The U.S. Pharmacopeial Convention is pleased ... Clinical Pharmacy Services at North Carolina State’s College of ... 2015 Beal Award for Distinguished Volunteer Service—the organization’s highest ... the contributions of volunteer experts to direct its work ...
(Date:1/22/2015)... 23, 2015 LunaDress, with its top dressmaking ... industry. Now, the business is showing its latest designs of ... , According to the company’s CEO, all the fresh new ... with big discounts, up to 80% off. All the clothes ...
(Date:1/22/2015)... 22, 2015 Woodloch Pines, an all-inclusive ... selected by TripAdvisor as the number one best large hotel ... in the world for their annual Travelers’ Choice Awards. ... . The website is home to millions of unbiased and ...
(Date:1/22/2015)... January 22, 2015 Padre Murphy's and Owner ... of Pro Player Health Alliance (PPHA). The PPHA's ... in getting everyone, including NFL greats, treated for obstructive sleep ... leading groups supporting the cause in the valley. The most ...
(Date:1/22/2015)... 22, 2015 The Incredible Bulk is a ... to increase lean muscle by up to 30lbs in less ... attention of HealthyandFitZone.com’s Stan Stevenson, prompting an investigative review. , ... a step-by-step, scientific diet formula that allows the body to ...
Breaking Medicine News(10 mins):Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 2Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 3Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 4Health News:LunaDress Shows The Latest Styles Of Wedding Dresses In 2015 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2
... Institute for Child Health Research shows an association between ... research findings have just been published online in the ... of Nutrition studies at the Institute, Associate Professor Wendy ... 1800 adolescents from the long-term Raine Study and classified ...
... efforts may be much more sensitive than previously realized to ... scientists at Harvard University report this week. In some cases, ... the difference between a minor, localized outbreak and an epidemic ... Proceedings of the Royal Society B , comes amidst one ...
... HealthDay Reporter , WEDNESDAY, July 28 (HealthDay News) ... see someone having what appears to be a heart attack, ... can be as effective as CPR that includes mouth-to-mouth breathing, ... July 29 issue of the New England Journal of ...
... (TZDS), including rosiglitazone and pioglitazone, may be at increased ... for publication in The Endocrine Society,s Journal of ... taking both loop diuretics and TZDs may also be ... shows that increased fracture risk is associated with higher ...
... Reporter , WEDNESDAY, July 28 (HealthDay News) -- A ... of men with metastatic tumors resistant to standard hormonal ... Provenge (sipuleucel-T), improved survival by about four months compared ... However, with a round of treatment potentially costing $93,000, ...
... Serena Gordon HealthDay Reporter , WEDNESDAY, July 28 ... one day eliminate the need for the multiple daily finger ... their blood sugar levels. The new device was tested ... monitored their blood sugar without the need for daily recalibration. ...
Cached Medicine News:Health News:Western diet link to ADHD 2Health News:Small increases in vaccine cost can cause large gaps in protection 2Health News:Chest Compressions Alone Best With CPR 2Health News:Chest Compressions Alone Best With CPR 3Health News:Vaccine Boosts Survival for Men With Advanced Prostate Cancer: Study 2Health News:Vaccine Boosts Survival for Men With Advanced Prostate Cancer: Study 3Health News:Implantable Sensor Measures Blood Sugar Levels 2Health News:Implantable Sensor Measures Blood Sugar Levels 3
(Date:1/22/2015)... is pleased to announce the appointment of Dr. ... Biochemistry. Scott joins the company after previous scientific leadership positions ... course of his nearly 20 year career in therapeutics ... recognized thought leader in the biosensor field and particularly ...
(Date:1/22/2015)... , Jan. 22, 2015 /PRNewswire/ - Pivotal Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ... focus on Omega-3 therapies for cardiovascular disease and overall health ... Company,s accomplishments in 2014 and its outlook for 2015 from ... Fellow Shareholders, We would like to take this ...
(Date:1/22/2015)... , Jan. 22, 2015  Profil Institute for Clinical ... diabetes and obesity, announced today a new textbook,  Translational ... published by Springer, a leading global scientific publisher. ... and illustrate techniques for use in early phase clinical ...
Breaking Medicine Technology:BiOptix Expands Leadership Team with the Appointment of Dr. Scott Klakamp as Vice President of Chemistry and Biochemistry 2Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 2New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 3
... Techniques -PHILADELPHIA, Feb. 26 Discovering ... like searching in the proverbial haystack for an unknown number ... into the background, and many of them widely separated from ... other by fine threads, you might pull out clumps of ...
... discomfortLAS VEGAS, Feb. 26 Tying a shoe, ... The mobility of our fingers and wrists can often ... pain begins, and interferes with simple, everyday tasks. According ... the American Academy of Orthopaedic Surgeons (AAOS) ( ...
Cached Medicine Technology:The Children's Hospital of Philadelphia: New Gene-Searching Method Uncovers Possible New Targets for Crohn's Disease Drugs 2The Children's Hospital of Philadelphia: New Gene-Searching Method Uncovers Possible New Targets for Crohn's Disease Drugs 3The Children's Hospital of Philadelphia: New Gene-Searching Method Uncovers Possible New Targets for Crohn's Disease Drugs 4Got Pain? 2Got Pain? 3Got Pain? 4
... tool for the Humphrey Field Analyzer, ... and shows less inter-test variability than ... degree of reproducibility as Full Threshold ... correlate with the earlier glaucoma damage ...
... can trust its capabilities will expand ... and glaucoma therapy in one system. ... the optimal system for photocoagulation, post-cataract ... The push of a button is ...
... non-mydriatic fundus camera increases ... of fundus imaging. Compact, ... set the standard in ... a unique combination of ...
... is the new disruption laser from ... for applications in posterior capsulotomy (post-cataract ... laser is also used for trabeculotomy, ... It's another milestone in the development ...
Medicine Products: