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JCI online early table of contents: Oct. 18, 2010
Date:10/18/2010

; E-mail: emorrise@mail.med.upenn.edu.

View this article at: http://www.jci.org/articles/view/44596?key=4304e5eea9ceffdf4e1b


HEMATOLOGY: Understanding treatment failure after bone marrow transplantation

Some forms of cancer are treated by transplantation with blood or bone marrow from a genetically non-identical individual (i.e., treated by allogeneic BMT). The idea behind this is that immune cells known as T cells, in particular CTLs, from the donor will attack and destroy the cancer. The main cause of treatment failure is tumor recurrence due to loss of functional donor CTLs that target the tumor. A team of researchers, led by Ronjon Chakraverty, at University College London, United Kingdom, has now identified two mechanisms by which loss of functional donor CTLs occurs in mouse models of allogeneic BMT. Furthermore, they identified a way to overcome one of these mechanisms disrupting interactions between the proteins PD-1 and PD-L1 such that donor CTL function was partially restored. They therefore suggest that these data define a potential approach to prevent or treat tumor recurrence following allogeneic BMT.

TITLE: Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation

AUTHOR CONTACT:
Ronjon Chakraverty
University College London, London, United Kingdom.
Phone: 44.207.317.7513; Fax: 44.207.830.2092; E-mail: r.chakraverty@medsch.ucl.ac.uk.

View this article at: http://www.jci.org/articles/view/41446?key=600b45fdb2c3f6f905ac


NEPHROLOGY: Slowing progression of chronic kidney disease

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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
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