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JCI online early table of contents: Oct. 18, 2010
Date:10/18/2010

f high blood pressure. However, a team of researchers, led by Eric Olson, at the University of Texas Southwestern Medical Center at Dallas, and Eva van Rooij, at miRagen Therapeutics, Inc., Boulder, has now shown that genetic deletion of miR-21 does not have a similar effect mice lacking miR-21 showed the same heart remodeling in models of high blood pressure as did normal mice questioning its utility as a therapeutic target in this context.

miR-21 is a microRNA, i.e., it is a small RNA molecule with a potent ability to regulate protein expression. MicroRNAs can be inhibited quickly and easily using antagomirs, which are small inhibitory molecules that target a specific microRNA. They can also be genetically deleted. In an accompanying commentary, Edward Morrisey, at the University of Pennsylvania, discusses the distinct data obtained using the miR-21 antagomir and miR-21 genetic deletion and suggests that genetic inactivation should be the gold standard by which experiments using antagomirs are measured.

TITLE: Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice

AUTHOR CONTACT:
Eric N. Olson
University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.
Phone: 214.648.1187; Fax: 214.648.1196; E-mail: eric.olson@utsouthwestern.edu.

Eva van Rooij,
miRagen Therapeutics, Inc., Boulder, Colorado, USA.
Phone: 303.531.5952; Fax: 303.531.5094; E-mail: evanrooij@miragenrx.com.

View this article at: http://www.jci.org/articles/view/43604?key=261b03f0a2e7850d746a

ACCOMPANYING COMMENTARY TITLE: The magic and mystery of miR-21

AUTHOR CONTACT:
Edward E. Morrisey
University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Phone: 215.573.3010, Fax: 215.573.2094
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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