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JCI online early table of contents: Oct. 18, 2010
Date:10/18/2010

EDITOR'S PICK: The protein NOS2 isn't good for ER-negative breast cancer patients

Breast cancers can be divided into different subtypes based on several criteria, including whether or not they express the protein to which the female hormone estrogen binds; that is, the estrogen receptor (ER). Patients with ER-negative breast tumors have a worse outlook than those with ER-positive breast tumors. However, even among ER-negative breast tumors, those characterized as basal-like are the most aggressive and difficult to treat. New therapeutic targets for this subtype of breast cancer are urgently needed. Now, a team of researchers, led by Stefan Ambs, at the National Cancer Institute, Bethesda, report data that suggest that the protein NOS2 could be a good drug target in this context. The data, generated by analysis of human breast cancer samples and cell lines, lead the authors to conclude that high levels of NOS2 are a predictor of survival in patients with ER-negative breast tumors and to suggest that selective NOS2 inhibitors might be of benefit to these individuals.

TITLE: Increased NOS2 predicts poor survival in estrogen receptornegative breast cancer patients

AUTHOR CONTACT:
Stefan Ambs
National Cancer Institute, Bethesda, Maryland, USA.
Phone: 301.496.4668; Fax: 301.480.4676; E-mail: ambss@mail.nih.gov.

View this article at: http://www.jci.org/articles/view/42059?key=e19810fc296c1ecf1474


DERMATOLOGY: Blistering analysis reveals disease cause in autoimmune skin condition

Pemphigus is an autoimmune condition (i.e., it is caused by an individual's immune system turning on their own body) that can be fatal if left untreated. It is characterized by skin blisters, which arise because immune molecules in the body known as antibodies start targeting the
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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