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JCI online early table of contents: Nov. 8, 2010
Date:11/8/2010

University, University Park, have now identified a pathway responsible for the production of new red blood cells shortly after bone marrow transplantation in mice. Specifically, they find that signaling initiated by the protein BMP4 promotes the development of red blood cell precursors in the spleen. These cells act to produce red blood cells in the immediate aftermath of bone marrow transplantation and function until the bone marrow transplant has taken hold and can take over the job of generating red blood cells. The authors point out that it might be possible to promote red blood cell production by targeting the BMP4 signaling pathway but that it will be necessary to determine whether or not this pathway functions in humans before its real clinical impact is known.

TITLE: Murine erythroid short-term radioprotection requires a BMP4-dependent, self-renewing population of stress erythroid progenitors

AUTHOR CONTACT:
Robert F. Paulson
Pennsylvania State University, University Park, Pennsylvania, USA.
Phone: 814.863.6306; Fax: 814.863.6140; E-mail: rfp5@psu.edu.

View this article at: http://www.jci.org/articles/view/41291?key=2756ef91cfa2b2e8f486


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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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