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JCI online early table of contents: Nov. 8, 2010
Date:11/8/2010

City, Iowa, USA.
Phone: 319.335.7867; Fax: 319.335.6957; E-mail: Kevin-campbell@uiowa.edu.

View this article at: http://www.jci.org/articles/view/42390?key=1aea8d028bb4436c8ab1


PULMONARY BIOLOGY: Explaining a key aspect of an inherited lung disease

Some individuals inherit a defect in production of the protein alpha-1 antitrypsin (AAT). This causes a chronic lung disease that is characterized by excessive numbers of immune cells known as neutrophils in the lungs. A team of researchers, led by Emer Reeves, at the Royal College of Surgeons in Ireland, has now identified two mechanisms explaining why human neutrophils accumulate in the lungs of individuals with an AAT deficiency, something previously unknown. Of clinical interest, AAT augmentation therapy counteracted these mechanisms, providing insight into why it works to reduce the lung disease associated with AAT deficiency.

TITLE: alpha-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8

AUTHOR CONTACT:
Emer P. Reeves
Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.
Phone: 353.1.8093877; Fax: 353.1.8093808; Email: emerreeves@rcsi.ie.

View this article at: http://www.jci.org/articles/view/41196?key=aa6adc1ee1b4975f1356


HEMATOLOGY: Rescuing red blood cell production after a bone marrow transplant

Bone marrow transplantation is used to treat some forms of cancer and some other diseases that affect blood cells. One complication after a bone marrow transplant is anemia, i.e., low levels of red blood cells. Robert Paulson and colleagues, at Pennsylvania State
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Contact: Karen Honey
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Journal of Clinical Investigation
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