Navigation Links
JCI online early table of contents: Nov. 8, 2010
Date:11/8/2010

the protein Enigma promotes p53 degradation. Among the several lines of evidence that this mechanism has a role in tumor development and progression was the observation that Enigma promoted human cancer cell line survival and resistance to chemotherapy by suppressing p53-induced cell death in a mouse xenograft model. The authors therefore suggest that Enigma could be new therapeutic target for selective activation of the tumor suppressor p53.

TITLE: Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice

AUTHOR CONTACT:
Dong-Soo Im
Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea.
Phone: 82.42.860.4172; Fax: 82.42.860.4597; E-mail: imdongsu@kribb.re.kr.

View this article at: http://www.jci.org/articles/view/42674?key=efd09435f3d59063fb1c


DERMATOLOGY: Improving wound healing in diabetes

Individuals with diabetes are at increased risk of wounds not healing properly, and this leads to over 72,000 amputations each year. Impaired generation of new blood vessels at the wound site is a key factor behind poor wound healing in these patients. This in turn is in part because cells responsible for making new blood vessellining cells (endothelial progenitor cells) are functionally impaired. A team of researchers, led by Alex Chen, at the University of Pittsburgh School of Medicine, Pittsburgh, has now identified a reason why endothelial progenitor cells are defective in diabetic mice.

In the study, endothelial progenitor cells were found to express decreased levels of the protein manganese superoxide dismutase and this reduced their ability to contribute to new blood vessel generation, thereby impairing wound healing. Importantly, gene therapy to replace manganese superoxide dismutase in endothelial progenitor cells fro
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
2. Web Content Management Enables Government Transparency, Participation, and Collaboration Online
3. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. Pharmahelper Pleased To Recognize Online Pharmacy Practice Standards Announced By Google Adwords
6. Online Dating Reinvents Itself with the Recent Roll-Out of Teacherhookup.com, a Free Website that Focuses on a Person's Career in Education!
7. EdenHome.com Adds Aventura Organic Clothes to Site and Announces Largest Online Selection of Stylish Organic Clothes for Men, Women and Children
8. Fire Protection Online Resolves Safety Concerns with CO2 Fire Extinguishers
9. JCI online early table of contents: Feb. 15, 2010
10. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
11. New Online Store Makes Buying Cosmetics a Healthy Choice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... Angeles, CA (PRWEB) December 22, 2014 ... reputable PALS, BLS and ACLS online certification provider, are ... http://www.acls-pals-bls.com . The updated site now features a ... easier than ever to use. , As a ... peoples’ information is now consolidated into a single page ...
(Date:12/22/2014)... U.S. and state health officials are investigating a listeria ... least four people and sickened 28 others in 10 ... prepackaged caramel apples until more information becomes available, the ... a news release. As of Dec. 18, a ... outbreak strains of the bacteria Listeria monocytogenes . ...
(Date:12/22/2014)... 22, 2014 Super Saturday, the last ... year as the busiest day in the 2014 holiday ... Grass Station had a steady pre-Christmas stream of customers, ... past Saturday. , “I definitely intend to take advantage…of ... Denver resident who was enjoying The Grass Station’s holiday ...
(Date:12/22/2014)... recognition of Veteran’s Day, Discount Labels contributed a portion ... that provides services to veterans and their families, free ... hundred acres in the hills of Southern Indiana, the ... hiking, horseback riding, 4-wheeling, skeet shooting, and much more. ... U.S. Service men and women, police officers, fire fighters ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 7,178 small ... bustle of Black Friday shopping and opted instead to ... marketing education company, for their 5th annual “Black Friday ... charged just $7 to attend the 5 hour online ... they promptly donated to support two Central Texas based ...
Breaking Medicine News(10 mins):Health News:ACLS Online Certification Website ACLS-PALS-BLS.com Now Features a New and User-Friendly Layout 2Health News:CDC Warns of Listeria Danger From Caramel Apples 2Health News:Customers at Colorado’s Grass Station Say They’re Enjoying the Experience of Legally Purchasing Marijuana this Year to Give as Christmas Presents to Friends and Family 2Health News:Discount Labels Donates Portion of November Sales to Hero Reward Program 2Health News:Austin Company Digital Marketer Raises 100K to Fight Childhood Cancer 2Health News:Austin Company Digital Marketer Raises 100K to Fight Childhood Cancer 3
... as Fully as Possible , ALEXANDRIA, Va., March 3 ... all people to know that hospice delivers the highest ... who are coping with life-limiting illness. A recent article ... Quandary," by Greg Bluestein, 03/02/09) carries a misinformed quote ...
... BOSTON, March 3 Solos Endoscopy, Inc. (Pink Sheets: ... completed a Food and Drug Administration (FDA) Level II ... for the inspection. It is standard for the FDA ... and the successful inspection by the FDA validates the ...
... and non-alcoholic steatohepatitis (NASH) are well-recognized causes ... and hepatocellular carcinoma. To date, no therapy ... conditions and no approved therapeutic options are ... plays a central role in insulin resistance ...
... chronic liver inflammation of unknown etiology that is characterized ... tissue damage. In the past few years, the understanding ... that, in a genetically predisposed individual, certain agents such ... self-induced liver damage. , Dr. Waleed K Al-Hamoudi ...
... 3 NuVasive, Inc. (Nasdaq: NUVA ), ... minimally disruptive surgical treatments for the spine, announced today ... Kevin O,Boyle, Executive Vice President & Chief Financial Officer, ... Healthcare Conference at Loews Miami Beach Hotel in Miami ...
... -- China Sky One,Medical, Inc. ("China Sky One ... ), a,leading fully integrated pharmaceutical company producing over-the-counter,drugs ... announced that it,obtained production approval from the State ... Folinate Injection. Another two new traditional Chinese,medicines, Paeonol ...
Cached Medicine News:Health News:NHPCO Comments on Misleading Quote in Associated Press Article and Provides Helpful Information 2Health News:Solos Endoscopy, Inc. Successfully Completes FDA Inspection 2Health News:Is telmisartan effective in treating non-alcoholic steatohepatitis? 2Health News:Is telmisartan effective in treating non-alcoholic steatohepatitis? 3Health News:Varicella zoster infection causes severe autoimmune hepatitis 2Health News:NuVasive to Present at Barclays Capital Global Healthcare Conference 2Health News:NuVasive to Present at Barclays Capital Global Healthcare Conference 3Health News:China Sky One Medical Inc. Gets SFDA Approval for Calcium Folinate Injection 2Health News:China Sky One Medical Inc. Gets SFDA Approval for Calcium Folinate Injection 3
(Date:12/19/2014)...  Newport Corporation (NASDAQ: NEWP ) ... the company,s Board of Directors.  Dr. Kadia is ... of Evans Analytical Group, a leading global provider ... to companies in a wide range of industries.   ... Group, Dr. Kadia spent nine years with Life ...
(Date:12/19/2014)... , Dec. 19, 2014   Hospira, Inc. ... provider of injectable drugs and infusion technologies, today announced ... 33rd Annual Healthcare Conference on Wednesday, Jan. 14, 2015, ... is scheduled to begin at 10:30 a.m. Pacific time ... to all interested parties through a live audiocast accessible ...
(Date:12/19/2014)... CARDIFF-BY-THE-SEA, Calif. , Dec. 19, 2014 /PRNewswire/ ...  Sorrento), an oncology company developing new treatments for ... privately-held immuno-oncology company developing proprietary Neukoplast ® ... announced today that the companies have entered into ... CAR-TNK™ (pronounced as "Car-Tank") immunotherapies for the treatment ...
Breaking Medicine Technology:Siddhartha Kadia, Ph.D. Joins Board of Directors of Newport Corporation 2Sorrento and Conkwest Announce Exclusive Global Collaboration 2Sorrento and Conkwest Announce Exclusive Global Collaboration 3Sorrento and Conkwest Announce Exclusive Global Collaboration 4Sorrento and Conkwest Announce Exclusive Global Collaboration 5
... 28 Pilgrim Software, Inc. , a world-leading ... and Quality Management ( ERCQM ) software ... Solutions Group, Inc., a California-based systems integration software provider. ... will deliver its products to an expanded base of ...
... Inc. announced today that it has initiated a Phase ... in normal, healthy subjects. "We are ... of AM152, a potentially novel anti-fibrotic agent.  Our first ... pharmacokinetic (PK) profile of this compound in normal healthy ...
Cached Medicine Technology:Pilgrim Software and Portford Solutions Sign Strategic Reseller Agreement 2Pilgrim Software and Portford Solutions Sign Strategic Reseller Agreement 3Amira Pharmaceuticals Announces Initiation of Phase I Clinical Trial for AM152, A Novel LPA1 Antagonist 2
Pediatric size. Loops retract lids. Polished finish....
Open ring design with shaft angled at 45 degrees. Blunt teeth. Round knurled handle with dull finish....
Fixation ring with atraumatic teeth provides excellent stabilization and pressure on globe. Round knurled handle with dull finish....
... Designed to fixate the eye ... two-sided ring can easily be ... or smooth side on the ... to the eye to increase ...
Medicine Products: