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JCI online early table of contents: Nov. 8, 2010
Date:11/8/2010

EDITOR'S PICK: PIT(-1)ting good and bad outcomes against each other in breast cancer

The outlook for patients with breast cancer is determined in part by whether or not their tumor has spread to other sites in the body. A team of researchers, led by Roman Perez-Fernandez and colleagues, at the University of Santiago de Compostela, Spain, has now identified in a subset of patients with breast cancer, a marker associated with the occurrence of tumors at distant sites; a finding that they hope might help predict a patient's outlook more accurately. Specifically, the team found that in patients with breast cancer that was accompanied by the presence of tumor cells in nearby lymph nodes, high levels of expression of the protein Pit-1 were associated with tumor spread to distant sites. The authors therefore suggest that analysis of Pit-1 expression in human breast tumor samples could help predict the outlook for patients with lymph nodepositive breast cancer.

TITLE: Deregulation of the Pit-1 transcription factor in human breast cancer cells promotes tumor growth and metastasis

AUTHOR CONTACT:
Roman Perez-Fernandez
University of Santiago de Compostela, Santiago de Compostela, Spain.
Phone: 34.8818.12257; Fax: 34.981.574145; E-mail: roman.perez.fernandez@usc.es.

View this article at: http://www.jci.org/articles/view/42015?key=b82dbe71403c8d490e53


ONCOLOGY: An Enigma for tumor suppression

One of the most well studied suppressors of tumor formation and development is the protein p53. A team of researchers, led by Dong-Soo Im, at the Korea Research Institute of Bioscience and Biotechnology, South Korea, has now provided new insight into how levels of this protein are regulated in human cell lines. Specifically, the team identified a mechanism by which
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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