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JCI online early table of contents: Nov. 6, 2008
Date:11/6/2008

na.Bhardwaj@nyumc.org.

View the PDF of this article at: https://www.the-jci.org/article.php?id=31350


PHYSIOLOGY: Identifying stem cells in the esophagus

The cells in our body are constantly being replaced with new ones, which are often derived from local populations of stem cells. In many parts of the body these stem cell populations are not well characterized. Now, Anil Rustgi and colleagues, at the University of Pennsylvania, Philadelphia, have identified a potential population of stem cells responsible for maintaining the epithelial cells lining the mouse esophagus (the part of the intestine that links the throat to the stomach). Importantly, administration of the cells, identified as CD34+, to mice with a damaged esophageal epithelium reconstituted the lining of the esophagus. As the esophagus is often exposed to noxious agents, e.g., acid, bile, and infection, the authors hope that these data will provide new insight into the response of the esophageal epithelium following injury and initiate studies to determine whether dysregulation in this process contributes to the development of esophageal cancer.

TITLE: A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification

AUTHOR CONTACT:
Anil K. Rustgi
University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Phone: (215) 898-0154; Fax: (215) 573-2024; E-mail: anil2@mail.med.upenn.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=35012


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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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