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JCI online early table of contents: Nov. 6, 2008
Date:11/6/2008

Phone: 61-2-95656156; Fax: 61-2-95656101; E-mail: j.rasko@centenary.usyd.edu.au.

View the PDF of this article at: https://www.the-jci.org/article.php?id=36625


ONCOLOGY: Getting rid of J(u)NK impairs human liver cancer growth in mice

A type of liver cancer known as hepatocellular carcinoma (HCC) is the third most common cause of death from cancer in the world. Erwin Wagner and colleagues, at the Research Institute of Molecular Pathology, Austria, have now provided insight into the signaling molecules that control the proliferation of HCC cells, and suggest that targeting one of these molecules (JNK1) should be considered as a potential therapeutic approach for the treatment of individuals with HCC.

In the study, activation of the protein JNK1 but not JNK2 was increased in human primary HCC samples. Furthermore, JNK1 was required for human HCC cells to proliferate in vitro and form tumors when they were transplanted into mice. Mechanistically, decreased proliferation and tumor development were associated with increased expression of the protein p21 and reduced expression of the protein c-Myc. Crucial support for the authors suggestion that targeting JNK1 might be beneficial to individuals with HCC came from the observation that treatment with a inhibitor of JNK1/2 markedly decreased the growth of human HCC cells transplanted into mice.

TITLE: Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation

AUTHOR CONTACT:
Erwin F. Wagner
Spanish National Cancer Research Center, Madrid, Spain.
Phone: 34-917-328-000 ext. 3800; Fax: 34-912-246-980; E-mail: ewagner@cnio.es.

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Journal of Clinical Investigation
Source:Eurekalert

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