Navigation Links
JCI online early table of contents: Nov. 6, 2008
Date:11/6/2008

EDITOR'S PICK: Visualizing asthma-causing immune cells at work

Immune cells known as eosinophils have a central role in causing asthma. Now, a team of researchers at Massachusetts General Hospital, Boston, has developed approaches to noninvasively visualize in real-time eosinophil responses in the lungs and airways of mice with a disease that mimics asthma (experimental allergic airway inflammation); they hope that these approaches might be developed to help assess the efficacy of treatments (both old and new) for the disease.

The team, led by Mikael Pittet and Ralph Weissleder, visualized eosinophils at single-cell resolution using various noninvasive real-time molecular imaging technologies (specifically, near-infrared fluorescence fiber optic bronchoscopy, intravital microscopy, and fluorescence-mediated tomography) following injection of an optical sensor that targets proteins produced by eosinophils known as MMPs. Using a combination of the sensitive optical sensor and fluorescence-mediated tomography, it was observed that dexamethasone (a drug used to treat severe asthma) decreased the number of eosinophils in the lungs of mice with allergic airway inflammation. As some of the imaging techniques have the potential to be developed for the clinic, the authors suggest that in combination with an appropriate optical sensor they might improve our ability to diagnose asthma and assess treatment efficacy.

TITLE: Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation

AUTHOR CONTACT:
Mikael J. Pittet
Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Phone: (617) 726-6481; Fax: (617) 726-5708; E-mail: mpittet@mgh.harvard.edu.

Ralph Weissleder
Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Phone: (617) 726-6481; Fax: (617)
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Three Women in Health Crises Go Online to Form Lifelong Friendships : Mothers of Boys with Cancer Find Support, Encouragement and Each Other at CarePages.com
2. Customers Now Able to Receive Real Time, Online Assistance during Health Insurance Quote Process
3. ENVOII System Tray Notifier(TM) Demo Now Available Online
4. Online Nursing Degree Seekers Gain a New Education Resource: OnlineNursingCareer.com
5. New Online Support Site Offers Hope, Information, and Help for Patients Who Have Suffered a Catastrophic Injury
6. Capella University Offers New MS in Psychology Specialization in Child and Adolescent Development : Capella is the only regionally accredited online university to offer this master's specialization
7. CVS Caremark Partners with Google Health to Provide Consumers with Online Access to their Prescription History through Caremark.com
8. Gonzaga Online Updates Communications Masters Program To Meet the Needs of Today's Professionals
9. Capella University Launches PhD in Counselor Education and Supervision : The new degree program, one of few available online, addresses growing need for counseling faculty and supervisors
10. Gather and Harvard Health Publications Launch New Programs to Bring Harvard Medical School Doctors Expertise Online
11. NABP Findings Underscore Dangers of Purchasing Prescription Medicine Online and From Foreign Sources
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... (GSA) and the National Center for Creative Aging ... University as the 2014 recipient of the Gene D. ... award recognizes and honors the seminal work of Gene ... and aging shifted the conceptual focus from a problem ... individuals to approach longevity asking what wonders can be ...
(Date:7/29/2014)... boys with fragile X syndrome tend to decline ... of the inherited disorder to date has found. ... social and practical skills, including communication, socialization, and ... dressed. In this study, socialization emerged as a ... that it did not decline as much as ...
(Date:7/29/2014)... More Zeppelin than Zen, the Rock Spa® at Seminole Hard ... complete renovation and, upon its re-opening in the fall, will ... , The Rock Spa® will include an all-new hair and ... hair and nail stylists. Both part time and full time ... given full medical and health benefits, a rare perk in ...
(Date:7/29/2014)... Society of America (GSA) the nation,s largest ... has chosen Laura N. Gitlin, PhD, of the Johns ... 2014 recipient of the M. Powell Lawton Award. ... gerontology that has led to an innovation in gerontological ... barriers, or a public policy change that has led ...
(Date:7/29/2014)... truBrain has created a solution for ... drinks. Think Drinks , available today on Indiegogo, ... conditions for memory, complex reasoning and sustained energy while ... $50,000 over the course of the 30-day campaign. , ... have compounding effects over time when used as a ...
Breaking Medicine News(10 mins):Health News:Charon to receive 2014 Gene D. Cohen Award 2Health News:Socialization relative strength in fragile X longitudinal study 2Health News:Rock Spa® at Seminole Hard Rock Hotel & Casino Tampa Prepares for Expansion 2Health News:Gitlin earns GSA's 2014 M. Powell Lawton Award 2Health News:Focus- and Productivity-Enhancing Beverage Launches Crowdfunding Campaign on Indiegogo 2
... The American College of Radiology (ACR) and Society of ... Obstetricians and Gynecologists, (ACOG) recommendations that women begin getting ... now correspond with those of the American Cancer Society, ... Breast Disease (ASBD) and many other major medical associations ...
... HealthDay Reporter , WEDNESDAY, July 20 (HealthDay News) -- ... disease as a major health threat, fearing its onset nearly ... Germany, Poland, Spain and the United States, the poll also ... to visit a doctor if they or a loved one ...
... HealthDay Reporter , WEDNESDAY, July 20 (HealthDay News) ... players can quantify the force of impact, offering new insight ... collisions may eventually help manufacturers design helmets that are more ... the University of Michigan and lead author of a new ...
... (HealthDay News) -- Premature infants are at greater risk ... hyperactivity and depression, a new study suggests. These ... affecting cortical development as well as neural connectivity, said ... Although "preemies" are at risk for these injuries, the ...
... gene-based test to distinguish harmless from precancerous pancreatic cysts. ... needless surgery to remove the harmless variety. A ... 20 issue of Science Translational Medicine . ... more than a million patients each year, most of ...
... a special fascination for Marlene Zuk , world-class evolutionary ... offer us, she says, a way to understand living things ... "People have strong feelings about insects, and most of those ... at the University of California, Riverside. "But insects let ...
Cached Medicine News:Health News:ACR, SBI support updated ACOG recommendations that women begin annual mammograms at age 40 2Health News:International Poll Shows Many Fear Alzheimer's as Much as Cancer 2Health News:International Poll Shows Many Fear Alzheimer's as Much as Cancer 3Health News:High-Tech Football Helmets Gauge Force of Collision 2Health News:Preemies at Risk for Psychiatric Disorders as Teens, Study Contends 2Health News:Benign or cancerous? Gene test predicts cancer potential in pancreatic cysts 2Health News:Benign or cancerous? Gene test predicts cancer potential in pancreatic cysts 3Health News:'Sex on Six Legs' is focus of UC Riverside biologist's book 2Health News:'Sex on Six Legs' is focus of UC Riverside biologist's book 3Health News:'Sex on Six Legs' is focus of UC Riverside biologist's book 4
(Date:7/29/2014)... COLORADO SPRINGS, Colo. , July 29, 2014 /PRNewswire-USNewswire/ ... remote-controlled catheter (MARC) which could allow physicians to see ... stroke may hold promise, according to study authors who ... Surgery (SNIS) 11 th Annual Meeting in ... findings stand to advance the field of neurointervention, a ...
(Date:7/29/2014)... NASHVILLE, Tenn. and NEW YORK ... and member of the executive management team of Caremark ... of PBM365 Media ( www.pbm365.com ).  PBM365 is the ... and unbiased reporting, insight, analysis and opinion on ... PBM365 will provide insightful and timely coverage of, ...
(Date:7/29/2014)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) launched its presence ... Clinical Lab Expo today by unveiling two booths (#1209 ... partnering with customers to redefine the value of the ... that they,re looking for a partner to help them ... offices," said Jack Phillips , president and CEO ...
Breaking Medicine Technology:New Technology May Improve Visualization Of The Brain During Stroke Treatment 2New Technology May Improve Visualization Of The Brain During Stroke Treatment 3Drew Crawford Announces Launch of PBM365 Media 2Roche focuses on partnering with customers to redefine the value of the laboratory at the AACC 2014 Clinical Lab Expo 2Roche focuses on partnering with customers to redefine the value of the laboratory at the AACC 2014 Clinical Lab Expo 3Roche focuses on partnering with customers to redefine the value of the laboratory at the AACC 2014 Clinical Lab Expo 4
... Inc . announced today that David A. Weber, Ph.D. , ... Board of Directors. Jay Lichter, Ph.D., managing director of Avalon Ventures, ... actively support the company as a member of the Board of ... to the Otonomy team, as his extensive experience in the development ...
... 2010 Amicus Therapeutics (Nasdaq: FOLD ), ... diseases, today announced that it has been awarded a ... Parkinson,s Research (MJFF) for the development of a novel, ...  The $500,000 award will be distributed over a period ...
Cached Medicine Technology:Otonomy Appoints David A. Weber, Ph.D., Chief Executive Officer 2Otonomy Appoints David A. Weber, Ph.D., Chief Executive Officer 3Amicus Therapeutics Awarded $500,000 Grant from The Michael J. Fox Foundation for Development of Next-Generation Pharmacological Chaperone to Treat Parkinson's Disease 2Amicus Therapeutics Awarded $500,000 Grant from The Michael J. Fox Foundation for Development of Next-Generation Pharmacological Chaperone to Treat Parkinson's Disease 3Amicus Therapeutics Awarded $500,000 Grant from The Michael J. Fox Foundation for Development of Next-Generation Pharmacological Chaperone to Treat Parkinson's Disease 4Amicus Therapeutics Awarded $500,000 Grant from The Michael J. Fox Foundation for Development of Next-Generation Pharmacological Chaperone to Treat Parkinson's Disease 5
Colloidal Gold Conjugated, Protein A - 12 OD...
Polyester ribbons (3) impregnated with different OD values of conjugated Protein G...
Colloidal Gold Conjugated, Protein G - 12 OD...
Colloidal Gold Sol, 40 nm - 50 OD, 1 ml, Gold Sol Nanoparticles - not boiled, not centrifuged...
Medicine Products: