Navigation Links
JCI online early table of contents: Nov. 21, 2011
Date:11/21/2011

EDITOR'S PICK: Boosting the aged immune response to flu virus

As people age, their immune system becomes less robust. This makes them more susceptible to serious and frequently life-threatening infections with viruses that affect the respiratory tract such as influenza A virus (IAV). Stanley Perlman and colleagues, at the University of Iowa, Iowa City, have now identified a new immune system defect in aged mice that makes them more susceptible than young mice to developing severe clinical disease upon infection with respiratory viruses such as IAV. Importantly, they were able to reverse the defect by inhibiting the immune molecule PGD2. Perlman and colleagues therefore suggest that inhibition of PGD2 could provide a way to improve clinical outcomes in older patients with severe respiratory viral infections and perhaps more importantly enhance the efficacy of flu vaccines in the elderly.

In an accompanying commentary, Thomas Braciale and Taeg Kim, at the University of Virginia, Charlottesville, discuss in more detail the clinical significance of the work of Perlman and colleagues.

TITLE: Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice

AUTHOR CONTACT:
Stanley Perlman
University of Iowa, Iowa City, Iowa, USA.
Phone: 319-335-8549; Fax: 319-335-9006; E-mail:
Stanley-perlman@uiowa.edu.

View this article at: http://www.jci.org/articles/view/59777?key=58c21b72794ae3c4465b

ACCOMPANYING COMMENTARY
TITLE: Slowing down with age: lung DCs do it too

AUTHOR CONTACT:
Thomas J. Braciale
University of Virginia, Charlottesville, Virginia, USA.
Phone: 434-924-1219; Fax: 434-924-1221; E-mail: tjb2r@virginia.edu
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

0

GOOD

Page: 1 2 3 4 5 6 7 8 9

Related medicine news :

1. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
2. Web Content Management Enables Government Transparency, Participation, and Collaboration Online
3. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. Pharmahelper Pleased To Recognize Online Pharmacy Practice Standards Announced By Google Adwords
6. Online Dating Reinvents Itself with the Recent Roll-Out of Teacherhookup.com, a Free Website that Focuses on a Person's Career in Education!
7. EdenHome.com Adds Aventura Organic Clothes to Site and Announces Largest Online Selection of Stylish Organic Clothes for Men, Women and Children
8. Fire Protection Online Resolves Safety Concerns with CO2 Fire Extinguishers
9. JCI online early table of contents: Feb. 15, 2010
10. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
11. New Online Store Makes Buying Cosmetics a Healthy Choice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2013)... 2013 ShopPharmacyCounter.com PhenObestin 37.5 Summer Sale ... announced price reductions on their popular PhenObestin 37.5 non-prescription ... clients to lose weight as effortlessly as possible has ... more than 50%. , Bottles have been reduced from ... all orders will receive free shipping. , Made ...
(Date:5/24/2013)... May 24, 2013 Today, Zane ... Indiana Health Insurance Exchange . Zane Benefits, ... employer sponsored health benefits, is the leader in ... reimbursement arrangements . , According to Zane Benefits’ ... Affordable Care Act (ACA), health insurance coverage for ...
(Date:5/24/2013)... 2013 DePuy ASR lawsuit ... to move forward in courts throughout the country, Bernstein ... California’s San Francisco Superior Court on April 25th, a ... her DePuy hip lawsuit is voluntarily seeking dismissal of ... al., No. CGC11508806; Calif. Super. Ct., San Francisco). , ...
(Date:5/24/2013)... Pomona, Calif. (PRWEB) May 24, 2013 ... has retained its status of “Full Accreditation” for the ... (AVMA) Council on Education (COE). , “This is a ... of our hard work and student outcomes,” said College ... want to express my appreciation to the faculty, staff, ...
(Date:5/24/2013)... 2013 With Memorial Day Weekend upon us, ... is offering tips to help prevent grill fires throughout ... Association (NFPA) reports that gas grills led to an ... or other solid-fueled grills, meanwhile, caused approximately 1,200 home fires ... Amica Insurance is sharing the following tips from the NFPA ...
Breaking Medicine News(10 mins):Health News:ShopPharmacyCounter.com PhenObestin 37.5 Summer Sale Now On 2Health News:Zane Benefits Publishes New Information on the Indiana Health Insurance Exchange 2Health News:Zane Benefits Publishes New Information on the Indiana Health Insurance Exchange 3Health News:Zane Benefits Publishes New Information on the Indiana Health Insurance Exchange 4Health News:DePuy ASR Hip Lawsuit News: Bernstein Liebhard LLP Notes Request for Voluntary Dismissal in California DePuy Hip Recall Case 2Health News:DePuy ASR Hip Lawsuit News: Bernstein Liebhard LLP Notes Request for Voluntary Dismissal in California DePuy Hip Recall Case 3Health News:DePuy ASR Hip Lawsuit News: Bernstein Liebhard LLP Notes Request for Voluntary Dismissal in California DePuy Hip Recall Case 4Health News:Don’t Get Burned: Five Grilling Tips from Amica Insurance 2
... June 25 Former U.S. Secretary of State Colin ... than 15,000 Lions volunteers from around the world and call ... these difficult economic times. , , (Logo: ... will deliver the keynote address on the importance and value ...
... 25 Futurist and world-recognized authority on technology trends ... Orthopaedic Manufacturing & Technology Exposition and Conference (OMTEC) by ... of care, not the price of technology. , ... to an ambulatory surgical center (ASC) has reduced costs ...
... help determine "who owns who" in the world of multi-level marketing. ... suit in state court in Volusia County, Florida, today, "The last ... All we wanted to do was build businesses and help others ... Univera leaders Marshall Douglas and Joe Land, are former distributors of ...
... PF Week Sept. 14 - 21 , , ... (CPF) announced today it has scheduled its 2009 National Pulmonary Fibrosis ... of this year,s activity are to ensure passage of the PFREA, ... in communities nationwide. , , Specifically, the CPF is asking ...
... Late diagnosis costs lives that could be saved with powerful ... Too many Americans with HIV are diagnosed late in the ... benefit of effective treatments, U.S. health officials reported Thursday. , ... but up to a third don,t know they have the ...
... S.D., June 25 The ,Help is Here Express, bus ... of June 29 - July 3 at various cities in ... on programs that provide prescription medicines for free or nearly ... compared to 2.9 percent a year ago, the Partnership for ...
Cached Medicine News:Health News:Colin Powell Applauds Lions for Leadership in Volunteerism as Interest in Volunteer Service Grows 2Health News:Technological Advancements Shift Site-of-Care From the Operating Room to Your Doctor's Office 2Health News:Former Associates File Suit Against Univera: Dietary Supplement Company Accused of Intimidation, Bullying, and Unfair Trade Practices 2Health News:CPF Announces Dates for Seventh Annual National Pulmonary Fibrosis Awareness Week 2Health News:CPF Announces Dates for Seventh Annual National Pulmonary Fibrosis Awareness Week 3Health News:CPF Announces Dates for Seventh Annual National Pulmonary Fibrosis Awareness Week 4Health News:Too Few Americans Get HIV Test Early Enough 2Health News:Too Few Americans Get HIV Test Early Enough 3Health News:Partnership for Prescription Assistance Prepared to Help South Dakota Workers Hurt by Recession 2Health News:Partnership for Prescription Assistance Prepared to Help South Dakota Workers Hurt by Recession 3Health News:Partnership for Prescription Assistance Prepared to Help South Dakota Workers Hurt by Recession 4
(Date:5/23/2013)... Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) announced today ... Executive Officer of Neurocrine Biosciences, will be presenting at the ... in Boston.   The live presentation takes place ... 8:20 a.m. Pacific Time.  The presentation will be webcast and ... . If you are unable to attend ...
(Date:5/23/2013)... , May 23, 2013 Hearing health affects ... feel younger, and remain socially and professionally engaged, he should ... the overriding message that the Better Hearing Institute ... of National Men,s Health Week , which leads up ... Week runs from June 10 through June 16. ...
(Date:5/23/2013)...  Hadasit Bio-Holdings Ltd. (TASE: HDST, OTC: HADSY), ... on intellectual property developed and owned by Hadassah ... medical research center, today announced that its portfolio ... from the Israeli Ministry of Industry and Commerce, ... product development and advance clinical trials. Cell Cure,s ...
Breaking Medicine Technology:Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 2Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 3Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 4Hadasit Bio-Holdings Ltd. Portfolio Company - Cell Cure Neurosciences Ltd. Received Additional Government Support 2
... include evaluation of safety and tolerability, ... Phase 2 trials -, ROCKVILLE, Md., May 30 ... announced that it has initiated dosing in a Phase,1 ... its lead IAP,inhibitor, HGS1029, as monotherapy in patients with ...
... Correlated With Clinical Response, CHICAGO, May ... today highlighted the potential of its,investigational MAGE-A3 ... studies evaluating highly targeted immunotherapy,as a treatment ... cancer,(NSCLC). These data were presented at the ...
Cached Medicine Technology:Human Genome Sciences Initiates First Clinical Trial of Lead IAP Inhibitor HGS1029 in Advanced Solid Tumors 2Human Genome Sciences Initiates First Clinical Trial of Lead IAP Inhibitor HGS1029 in Advanced Solid Tumors 3Human Genome Sciences Initiates First Clinical Trial of Lead IAP Inhibitor HGS1029 in Advanced Solid Tumors 4New Data on MAGE-A3 Cancer Immunotherapy Support Potential Novel Options of Treating Non-Small Cell Lung Cancer and Melanoma 2New Data on MAGE-A3 Cancer Immunotherapy Support Potential Novel Options of Treating Non-Small Cell Lung Cancer and Melanoma 3New Data on MAGE-A3 Cancer Immunotherapy Support Potential Novel Options of Treating Non-Small Cell Lung Cancer and Melanoma 4New Data on MAGE-A3 Cancer Immunotherapy Support Potential Novel Options of Treating Non-Small Cell Lung Cancer and Melanoma 5New Data on MAGE-A3 Cancer Immunotherapy Support Potential Novel Options of Treating Non-Small Cell Lung Cancer and Melanoma 6New Data on MAGE-A3 Cancer Immunotherapy Support Potential Novel Options of Treating Non-Small Cell Lung Cancer and Melanoma 7
... Biosense Webster offers a complete line ... in the atrium. The ISMUS CATH ... simple placement in the atrial isthmus. ... the catheter's distal tip permit pacing ...
... Biosense Webster is the source for ... catheters for left-sided mapping - all with ... come to expect from the leader in ... catheters are specifically designed and constructed to ...
... Inquiry H Steerable Catheter. ... a variety of designs and ... catheter stability. 10 to 24 ... curves, inactive and active tip ...
A steerable diagnostic catheter with optimal maneuverability...
Medicine Products: