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JCI online early table of contents: Nov. 15, 2010
Date:11/15/2010

function. This is predominantly because it must be incorporated into some proteins, in the form of selenocysteine, for them to function. A multiprotein complex that includes the protein SECISBP2 is responsible for incorporating selenocysteine into proteins. A team of researchers, led by Krishna Chatterjee, at the University of Cambridge, United Kingdom, has now identified two individuals with distinct mutations in their two SECISBP2 genes and characterized their clinical defects. These individuals had reduced levels of most of the 25 known human selenoproteins and this led to a complex multisystem disorder that included, but was not limited to, a lack of sperm, muscle wasting, increased sensitivity to UV light, and impaired thyroid function. This analysis has provided new insight into the diverse biological processes in which selenoproteins are involved.

TITLE: Mutations in the selenocysteine insertion sequencebinding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

AUTHOR CONTACT:
V. Krishna K. Chatterjee
University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.
Phone: 44.1223.336842; Fax: 44.1223.330598; E-mail: kkc1@mole.bio.cam.ac.uk.

View this article at: http://www.jci.org/articles/view/43653?key=c5d65a1724a465493437


TUMOR IMMUNOLOGY: Genetic modification: the secret to a long-lived antitumor immune response

One anticancer approach many researchers are seeking to develop is the transfer into patients of immune cells known as T cells that have been manipulated such that they attack and destroy the patient's tumor. Although this approach has proven beneficial in some individuals, in most, the antitumor immune response has not been long-lived enough to be of benefit. However, a team of researchers, led by Christo
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Contact: Karen Honey
press_releases@the-jci.org
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Journal of Clinical Investigation
Source:Eurekalert

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