Navigation Links
JCI online early table of contents: Nov. 15, 2010
Date:11/15/2010

e proportion of patients who become infected with hepatitis C virus (HCV), the virus evades the anti-viral immune response to establish a persistent infection. In these individuals, the function of HCV-specific immune cells known as CTLs is impaired as a result of inhibitory signals emanating from proteins such as Tim-3 and PD-1 on their surface. A team of researchers, led by Hugo Rosen, at the University of Colorado Denver, Aurora, has now generated data that suggest that blocking the inhibitory proteins Tim-3 and PD-1 might provide a new approach to treating individuals with a persistent HCV infection.

The team determined that expression of PD-1 and Tim-3 on HCV-specific CTLs was characteristic of individuals acutely infected with HCV who were more likely to develop persistent HCV infection. Importantly, blockade of either PD-1 or Tim-3 enhanced the in vitro proliferation of HCV-specific CTLs, while blockade of Tim-3 increased the ability of these cells to kill cells expressing HCV proteins. The authors therefore conclude that coexpression of PD-1 and Tim-3 on HCV-specific CTLs is associated with the development of persistent HCV infection and suggest that simultaneous blockade of PD-1 and Tim-3 might be therapeutically useful.

TITLE: Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity

AUTHOR CONTACT:
Hugo R. Rosen
University of Colorado Denver, Aurora, Colorado, USA.
Phone: 303.724.1858; Fax: 303.724.1891; E-mail: Hugo.Rosen@ucdenver.edu.

View this article at: http://www.jci.org/articles/view/43127?key=b248ddb642397e4495f7


PHYSIOLOGY: Patients explain exactly why we need the chemical element selenium

The trace element selenium is essential for cellular
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. JCI online early table of contents: Nov. 8, 2010
2. Online Feedback May Boost Weight-Loss Success
3. Online Gambling Rises Among College Males, High School Girls
4. JCI online early table of contents: Oct. 18, 2010
5. JCI online early table of contents: Sept. 13, 2010
6. JCI online early table of contents: Sept. 1, 2010
7. JCI online early table of contents: August 2, 2010
8. New online community launched to help medical practices learn about meaningful use
9. JCI online early table of contents: July 12, 2010
10. Online coverage of XVIII International AIDS Conference to include daily webcasts, live coverage, podcasts and news recaps
11. Sam's Club Tests Online Small Business Loan Program for Main Street
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Recently, Weddingshe.com has added many trendy Champagne wedding ... revenues in the past three years. Today, the business announces ... According to the sales manager of the company, this is ... 2015. This point can be reflected on the discounted wedding ...
(Date:1/22/2015)... 2015 Payday lending practices in four ... cause financial distress to the states that permit them, ... University’s Center on Race and Wealth. , While they ... payday loans at the same time substantially depress economic ...
(Date:1/22/2015)... JJsHouse.com is a famous dress online store for wedding dresses ... latest collection of wedding dresses , and launches a site-wide ... wedding dress on your big day; the wedding gown is ... wants to find the most suitable wedding dress. Now, we ...
(Date:1/22/2015)... Richmond, VA (PRWEB) January 22, 2015 ... the power at the Science Museum of Virginia. Wicked ... 24. , Wicked Plants unearths 75 poisonous, carnivorous and ... traverse through each room to uncover the biochemical, physical ...
(Date:12/26/2014)... 26, 2014 It is said that nothing ... Today, UWDress.com, the famous wedding dress supplier, shows its ... site-wide cocktail gown promotion. , UWDress.com’s navy cocktail gowns ... they come in high fashion styles. Simple dresses in bright ...
Breaking Medicine News(10 mins):Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2Health News:Wicked Plants are taking over the Science Museum of Virginia 2Health News:UWDress.com Shows Its New Navy Cocktail Dresses For 2015 2
... improvements and less cell degeneration , , SUNDAY, Feb. ... appears able to slow or stop Alzheimer,s disease in ... The brain,s entorhinal cortex, which supports memory, normally produces ... decrease when Alzheimer,s is present. When researchers injected BDNF ...
... Trust for America,s Health released the following statement after ... cut more than $100 billion from the American Recovery ... the Senate struck a final bargain to strip all ... plan, failing to recognize that this funding would have ...
... pain and swelling , , FRIDAY, Feb. 6 (HealthDay News) ... symptoms in people with rheumatoid arthritis (RA) has been ... study included two postmenopausal women with advanced RA. Researchers ... women,s affected joints. IL-1Ra protein blocks the actions of ...
... Aflac Incorporated,announced today that it is providing expanded detail ... The company has elevated additional ... and Tier 1 perpetual debenture, including CUSIP numbers for ... The company has also,prepared and elevated a frequently asked ...
... Supplies tend to run dangerously short this time of year , , ... gone, and everyone has settled back into regular routines. , But ... this time of the year. , The nation,s blood supply tends ... to a decline in donations. Now that the new year is ...
... with low glycemic index sweeteners and berries to produce a new type ... benefits of berry antioxidants and probiotics are also discussed with comments from ... ... long been regarded as a sweet and sinful indulgence. Everyone knows ...
Cached Medicine News:Health News:Brain Protein May Have Potential Against Alzheimer's 2Health News:Gene Therapy May Ease Rheumatoid Arthritis 2Health News:Aflac Incorporated Provides Added Detail on Perpetual Debenture Holdings 2Health News:Needed: Blood Donations 2Health News:Needed: Blood Donations 3Health News:Losing Weight with Chocolate on Valentine's Day 2
(Date:1/23/2015)... , Jan. 23, 2015 For the pharmaceutical industry, marketplace ... with payers. Likewise, the importance of the managed markets function ... continue to grow as payer formularies and provider networks play ... At the same time, managed markets leaders must continually ...
(Date:1/23/2015)... Jan. 23, 2015  The Partnership to Fight Chronic Disease (PFCD) released ... care leaders and a new study analyzing the impact of increased ... a nationwide coalition working to educate policy makers and the public ... Capitol was focused on how the Iowa ...
(Date:1/23/2015)... DUBLIN , Jan. 23, 2015  Immune Therapeutics, Inc. today ... Inc. for the compounding, packaging and distributing of its naltrexone ... the United States . KRS ... compounding naltrexone tablets in various strengths for individual patients in ...
Breaking Medicine Technology:As Payer Influence Rises, Pharmaceutical Companies work to Optimize the Managed Markets Function 2New research shows Iowa health exchange would benefit from improvements 2New research shows Iowa health exchange would benefit from improvements 3Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 2Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 3Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 4
... (NASDAQ: DCTH ) today announced the Therapeutic ... approved the Delcath Hepatic CHEMOSAT® Delivery system for listing ... TGA,s approval allows Delcath to market and sell the ... Australia represents another achievement for Delcath as we seek ...
... Feb. 14, 2012  Intellect Neurosciences, Inc. (OTCBB: ILNS), ... development of disease-modifying therapeutic agents for the treatment ... that it submitted a statement setting out its ... preliminary decision to revoke the company,s ANTISENILIN® patents ...
Cached Medicine Technology:Delcath Receives Regulatory Approval to Commercialize Hepatic CHEMOSAT® Delivery System in Australia 2Delcath Receives Regulatory Approval to Commercialize Hepatic CHEMOSAT® Delivery System in Australia 3Intellect Neurosciences Submits Statement Setting Grounds for Appeal in European Patent Proceedings 2Intellect Neurosciences Submits Statement Setting Grounds for Appeal in European Patent Proceedings 3Intellect Neurosciences Submits Statement Setting Grounds for Appeal in European Patent Proceedings 4
... Choice for Urinary Tract Infection ... Line. A multi-center study was ... potential UTIs. There were 1,887 ... leukocyte and nitrite results of ...
... busy physician's office environment, interruptions ... to timing errors and variability ... are read visually. Studies have ... performed with an instrument, sensitivity ...
Keep your laboratory efficient. And meet your volume needs. When you set the pace with the Clinitek 500 Urine Chemistry Analyzer. Its ready when you are. No warm-up. No calibration. No bells. Just pr...
... These dual pressure sensor ... sampling/slow-speed injection, slow-speed injection/guide wire, ... model SPC-784A for high-speed injection ... side openings and an open-end ...
Medicine Products: