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JCI online early table of contents: Nov. 14, 2011
Date:11/14/2011

te erythropoiesis (e.g., recombinant EPO) are used to treat some patients with anemia. However, these therapeutics, which are known as erythropoiesis-stimulating agents (ESAs), can have severe adverse side effects and there is a need for new and improved drugs. A team of researchers led by Koji Tamada, at the University of Maryland, Baltimore, has now identified a new signaling pathway that promotes erythropoiesis in mice. Stimulation of the protein HVEM initiates this pathway. Thus, Tamada and colleagues suggest that stimulation of HVEM signaling could provide a new therapeutic approach to treating individuals with conditions currently treated with ESAs such as recombinant EPO.

TITLE: Herpesvirus entry mediator regulates hypoxia-inducible factor𔂿a and erythropoiesis in mice

AUTHOR CONTACT:
Koji Tamada
University of Maryland, Baltimore, Maryland, USA.
Phone: 410-328-5114; Fax: 410-328-6559; E-mail: ktamada@som.umaryland.edu.

View this article at: http://www.jci.org/articles/view/57332?key=0c3878d826b1f73207bf

METABOLIC DISEASE: AMP(K)ed up protection from insulin resistance

The number of people who are obese is increasing dramatically. Being obese puts an individual at increased risk of developing type 2 diabetes and its associated adverse health conditions. This is in part because inflammatory cells known as macrophages accumulate in the fat tissue and produce inflammatory factors that contribute to the development of insulin resistance, a condition in which cells in the body fail to respond normally to the hormone insulin and that precedes diabetes. A team of researchers led by Gregory Steinberg, at McMaster University, Hamilton, has now determined that in mice, expression of the protein AMPK-beta-1 in bone marrowderived cells such as macrophages helps reduce fat tissu
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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