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JCI online early table of contents: Nov. 14, 2011
Date:11/14/2011

nsylvania, USA.
Phone: 412-623-3261; Fax: 412-623-4840; E-mail: chengs@upmc.edu.

View this article at: http://www.jci.org/articles/view/58559?key=c3e853c6e6fcc98d3b66

CARDIOLOGY: Grown up function for the protein Tbx20

Mutations in the gene TBX20 are associated with both congenital heart disease and a heart disease in adults known as cardiomyopathy, which puts people at risk of an irregular heart beat and/or sudden death. Consistent with the association with congenital heart disease in humans, the protein Tbx20 has a role in heart development in mice. However, the role of Tbx20 in the adult mouse heart has not been determined so there are no clues as to whether the association of TBX20 mutations with cardiomyopathy in adult humans is a result of defects in TBX20 function during development or adulthood. A team of researchers led by Marcelo A. Nobrega, at the University of Chicago, Chicago; and Sylvia M. Evans, at the University of California San Diego, La Jolla has now investigated this issue and determined that Tbx20 functions in adult mouse heart muscle cells to control the expression of genes involved in controlling the beating of the heart. If TBX20 has a similar function in adult human heart muscle cells, these data suggest that defects in TBX20 function during adulthood underlie the association of TBX20 mutations with cardiomyopathy in adult humans.

TITLE: Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function

AUTHOR CONTACT:
Marcelo A. Nobrega
University of Chicago, Chicago, Illinois, USA.
Phone: 773-834-7919; Fax: 773-83-.8470; E-mail: nobrega@uchicago.edu.

Sylvia M. Evans
University of California San Diego, La Jolla, California, USA.
Phone: 858-822-2452; Fax: 858-822-3027; E-mail: '/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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