Navigation Links
JCI online early table of contents: May 17, 2010
Date:5/10/2010

Keeping blood cells in check with the protein Lnk

Genetic mutations that lead to aberrant activation of the signaling protein JAK2 have been linked to several myeloproliferative diseases, a group of diseases of the bone marrow that includes chronic myeloid leukemia. Wei Tong and colleagues, at the University of Pennsylvania School of Medicine, Philadelphia, have now generated several lines of evidence in mice indicating that the protein Lnk acts as a suppressor of the development of JAK2-induced myeloproliferative diseases. For example, loss of Lnk accelerated and exacerbated JAK2-induced myeloproliferative diseases in mice. Furthermore, as old mice lacking Lnk spontaneously developed a myeloproliferative disease resembling chronic myeloid leukemia, the authors suggest that Lnk dysfunction might contribute to the development of cancers of the blood and bone marrow in humans.

TITLE: Lnk constrains myeloproliferative diseases in mice

AUTHOR CONTACT:
Wei Tong
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Phone: 267.426.0930; Fax: 267.426.5476; E-mail: tongw@email.chop.edu.

View this article at: http://www.jci.org/articles/view/42032?key=344a892df66bb135b5fd


NEUROBIOLOGY: Cellular help to activate thyroid hormone in the brain

Hypothyroidism is a medical condition caused by insufficient production of thyroid hormone. Although iodine deficiency is the most common cause of hypothyroidism, it can be inherited. In neonates, this form of hypothyroidism is accompanied by severe neurological consequences, indicating a role for thyroid hormone in the brain. However, little is known about the mechanisms regulating thyroid hormone action in the brain.

A team of researchers, led by Antonio Bianoc, at the University of Miami Mi
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. A medicine classic goes online and far afield
2. New Online Service Helps Patients Find Info on Pricing, Financial Assistance
3. Horizon Display Demonstrates their Dedication to After-Sales Support with Enhanced Online Resources
4. CareData Introduces Online Electronic Health Record Training Course for Allied Health Paraprofessionals
5. LeveragePoint Releases Complete Online Value Management Solution
6. SeaShine, LLC Announces the Launch of SeaShine Online Magazine, a Magazine for Women Who Positively Impact their Communities through Transparent Lifestyles
7. Leveragepoint Names Jay Manson Vice President Sales For Online Value Management Tools
8. Prize4Life Launches “Art, Life, Spring” Online Art Auction to Raise Funds for Lou Gehrig's Disease Research
9. ShenoaDiamonds.com Holds Contest to Give Away $5,000 Diamond Ring, Spurred by Online Sales Growth
10. New Online Stores & Online Shopping Collection Web Site
11. The Diet Solution Program: Popular Online Weight Loss Program is Revised to Include More Metabolism Boosting Meals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2014)... (PRWEB) December 20, 2014 Weddingshe.com has ... and launched a site-wide promotion of special occasion dresses ... a popular supplier of special occasion dresses for global ... offered with big discounts, up to 80% off. Among ... Sweetheart Sequins Short Sweet 16 Dress) is very popular. ...
(Date:12/20/2014)... Dec. 20, 2014 (HealthDay News) -- The holidays can ... they contend with fresh trees, scented candles and other ... on the decorations that have been packed away in ... my allergy and asthma patients," Dr. Rachna Shah, an ... of Medicine, said in Loyola news release. Shah, ...
(Date:12/20/2014)... 20, 2014 Atore, Inc, (San Francisco, ... launched first birthday focused portal on December 17th, 2014. ... launched in both US and Japan. , MERRY BIRTHDAY ... http://merrybirthday.net/message/ , MERRY BIRTHDAY MESSAGE is part ... the world. , Features, Choose from thousands of stock ...
(Date:12/20/2014)... Twin Cities DI Day is recognized as the premier ... financial professionals come together each year to hear up ... to protect their clients and to be inspired by ... of disability. , On September 23rd, 2014, financial professionals ... The 13th Annual Twin Cities DI Day where they ...
(Date:12/19/2014)... Sweetdressy.com , a leading wedding dress manufacturer for the ... prom dresses for ladies worldwide. The prom dresses from ... can buy these dresses at the website of Sweetdressy.com ... and delicate craftsmanship, and most of them are priced ... costs are available for all of their dresses. All ...
Breaking Medicine News(10 mins):Health News:Tons of New-in Winter Sweet 16 Dresses from Weddingshe Online Now 2Health News:Holiday Trimmings Can Trigger Allergies 2Health News:Atore, Inc. Releasing the First Birthday Portal 2Health News:The 13th Annual Twin Cities DI Day Now On Video 2Health News:The 13th Annual Twin Cities DI Day Now On Video 3Health News:Cheap Prom Dresses Online Now at Sweetdressy.com 2
... Health Plans Move Closer to Cutting AmerisourceBergen-Brand,Pharmacies ... WASHINGTON, Feb. 28 AmerisourceBergen (NYSE:,ABC) warehouse ... hundreds of,their fellow Teamsters outside ABC,s annual ... a warning to investors about,ongoing and illegal ...
... Standardized ... Digital RSA Solution, ... IDL), the global leader in digital radiography (DR) for image,quality ... as the DR component for an imaging product suite currently,under ...
... study from the American Cancer Society finds that while breast ... U.S. state, for African American women, death rates are either ... study, published early online in the journal Cancer Causes and ... are decreasing in only 11 of 37 states with sufficient ...
... Dental Experts to Advance ... of CCLAD in Dentistry, LIVINGSTON, N.J., Feb. 28 ... leader in,advanced injection technologies, today reported that earlier this ... (CCLAD) Summit in New Orleans. The Summit welcomed a ...
... to unprotected, masochistic sex as adults , , THURSDAY, Feb. ... consequence of spanking: risky sexual behaviors, or even sexual ... one more harmful side effect to spanking," said Murray ... the findings of four studies at the American Psychological ...
... on March 17, 2008 at 10:00 a.m., FREEHOLD, ... NAHC ) will report financial results,for the fourth ... March,17, 2008 prior to market open., The Company ... March,17, 2008 at 10:00 a.m. Eastern Time (ET). Following ...
Cached Medicine News:Health News:Teamsters Warn of Possible Work Stoppages, Service Disruptions at AmerisourceBergen 2Health News:IDC X-Series DR system selected for use in leading edge RSA clinical trial application 2Health News:IDC X-Series DR system selected for use in leading edge RSA clinical trial application 3Health News:Breast cancer death rates among black women not decreasing across all states 2Health News:Milestone Scientific Hosts First International Computer-Controlled Local Anesthetic Delivery (CCLAD) Summit 2Health News:Milestone Scientific Hosts First International Computer-Controlled Local Anesthetic Delivery (CCLAD) Summit 3Health News:Milestone Scientific Hosts First International Computer-Controlled Local Anesthetic Delivery (CCLAD) Summit 4Health News:Milestone Scientific Hosts First International Computer-Controlled Local Anesthetic Delivery (CCLAD) Summit 5Health News:Spanking Raises Chances of Risky, Deviant Sexual Behavior 2Health News:Spanking Raises Chances of Risky, Deviant Sexual Behavior 3Health News:National Atlantic Holdings Corporation to Report Fourth Quarter and Year-End 2007 Earnings on March 17, 2008 2Health News:National Atlantic Holdings Corporation to Report Fourth Quarter and Year-End 2007 Earnings on March 17, 2008 3
(Date:12/19/2014)... BOCA RATON, Fla. , Dec. 19, 2014 /PRNewswire/ ... entered into a multi-product agreement with MSN Laboratories Pvt. ... Breckenridge and MSN expect to commercialize several new ANDAs. ... manufacture, and supply the products exclusively to Breckenridge for ... the products under its label.  Breckenridge and MSN have ...
(Date:12/19/2014)... HILL, N.C. , Dec. 19, 2014 /PRNewswire/ ... to optimize a product,s web presence to reflect ... Brand websites, in particular, must meet the needs ... regulations and culture. According to ... more than half of the participating companies averaged ...
(Date:12/19/2014)... 2014  Monarch America Inc. (OTCQB: CANK) ("Monarch America" ... to provide this review of the Company,s recent achievements ... "Over this past year, we achieved many of ... proud to say that Monarch America is in a ... ever been," stated Eric Hagen , CEO of ...
Breaking Medicine Technology:Breckenridge Pharmaceutical signs Multi-Product Generic Agreement with MSN Laboratories Pvt. Ltd. 2Building a Best-in-Class Pharma Global Brand Website 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 3
... 14, 2011  Heska Corporation (NASDAQ: HSKA ; ... and specialty products to veterinarians, announced today the intent ... expertise in blood-related disorders.  The parties are to explore ... cell-based therapeutics, for use in the veterinary market.      ...
... Group, Inc. (OTCMARKETS: UYMG) "UNITY" (or the "Company"), and its ... it has sold its initial PZ Uno Tablet press to ... the company is not able to disclose the name of ... tablet press would be used for a research and development ...
Cached Medicine Technology:Heska Announces Exploration of New Technologies Through Strategic Collaboration with Entegrion, Inc. 2Heska Announces Exploration of New Technologies Through Strategic Collaboration with Entegrion, Inc. 3Unity Management Group, Inc. Announces Its Initial Sale of the PZ UNO Tablet Press to a Major Pharmaceutical Company for $500,000 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: