Navigation Links
JCI online early table of contents: May 17, 2010
Date:5/10/2010

f Medicine, Baltimore, Maryland, USA.
Phone: 410.706.8040; Fax: 410.706.8121; E-mail: lizhang@som.umaryland.edu.

View this article at: http://www.jci.org/articles/view/40380?key=5d28ec5e44ef710a94f1


DEVELOPMENT: How HOXD13 is all fingers and thumbs

A team of researchers, led by Stefan Mundlos, at the Institute for Medical Genetics, Charit, Germany, has provided new insight into the molecular control of the formation of the bones that make up the hands and feet by studying mice carrying a mutant form of the protein HOXD13 that leads in humans to limb malformations, including a characteristic extra digit between digits 3 and 4 and a fusion between these digits.

Our bones are formed from one of two types of tissue: cortical bone or trabecular bone. In the study, it was found that the bones of the hands and feet of the HOXD13 mutant mice failed to develop as cortical bone, rather they aberrantly developed as trabecular bone. In addition, the bones of the hand took on characteristics of wrist bones. Further analyses identified several mechanisms by which the mutant HOXD13 affected bone formation, increasing our understanding of the variable limb malformations seen in individuals with mutations in HOXD13 and RUNX2.

TITLE: Homeobox genes d11d13 and a13 control mouse autopod cortical bone and joint formation

AUTHOR CONTACT:
Stefan Mundlos
Institute for Medical Genetics, Charit, Universittsmedizin Berlin, Berlin, Germany.
Phone: 49.30.450.569.121; Fax: 49.30.450.569.915; E-mail: stefan.mundlos@charite.de.

View this article at: http://www.jci.org/articles/view/41554?key=44fe92b173a11d73a694


HEMATOLOGY:
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. A medicine classic goes online and far afield
2. New Online Service Helps Patients Find Info on Pricing, Financial Assistance
3. Horizon Display Demonstrates their Dedication to After-Sales Support with Enhanced Online Resources
4. CareData Introduces Online Electronic Health Record Training Course for Allied Health Paraprofessionals
5. LeveragePoint Releases Complete Online Value Management Solution
6. SeaShine, LLC Announces the Launch of SeaShine Online Magazine, a Magazine for Women Who Positively Impact their Communities through Transparent Lifestyles
7. Leveragepoint Names Jay Manson Vice President Sales For Online Value Management Tools
8. Prize4Life Launches “Art, Life, Spring” Online Art Auction to Raise Funds for Lou Gehrig's Disease Research
9. ShenoaDiamonds.com Holds Contest to Give Away $5,000 Diamond Ring, Spurred by Online Sales Growth
10. New Online Stores & Online Shopping Collection Web Site
11. The Diet Solution Program: Popular Online Weight Loss Program is Revised to Include More Metabolism Boosting Meals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... endogenous neural precursor cells cannot alone compensate for ... perspective of neural plasticity, Dr. Yun Xiang and ... the effects of functional electrical stimulation treatment on ... basic fibroblast growth factor and epidermal growth factor ... The researchers found that functional electrical stimulation can ...
(Date:4/22/2014)... industry leaders visited the New Jersey Institute of ... S. Bloom for the launch of the New ... provides a new model for business innovation through ... assets and investment. U.S. Senator Cory Booker, Panasonic ... Taylor, New Jersey Lieutenant Governor Kim Guadagno, New ...
(Date:4/22/2014)... Health clinics that can provide primary care for ... both hospitals and insurance companies while improving patient ... hospital admissions suggests that health clinics that avoid ... save money by lowering hospital admission rates and ... of economics, Penn State Altoona. , The ...
(Date:4/22/2014)... among women using a newer method of planned sterilization ... over a 10-year period than using the more commonly ... University and UC Davis has found. , Published ... the study found the higher risk of pregnancy with ... Essure. , "This study provides essential information for ...
(Date:4/22/2014)... mice and rabbits, Johns Hopkins scientists have found a ... successfully preventing the development of atherosclerosis, the main cause ... of death among humans. The condition develops when fat ... stiff, narrowed and hardened, greatly reducing their ability to ... brain. , In a series of experiments, described April ...
Breaking Medicine News(10 mins):Health News:Government and industry leaders herald launch of NJIT's New Jersey Innovation Institute 2Health News:Clinics not bogged down by red tape can ease health cost burdens 2Health News:Risk of pregnancy greater with newer method of female sterilization 2Health News:Risk of pregnancy greater with newer method of female sterilization 3Health News:Scientists alter fat metabolism in animals to prevent most common type of heart disease 2Health News:Scientists alter fat metabolism in animals to prevent most common type of heart disease 3Health News:Scientists alter fat metabolism in animals to prevent most common type of heart disease 4
... X-rays allowing, dentists to remineralize affected teeth. ... 3 /PRNewswire/ - Quantum Dental Technologies, a Canadian,diagnostic ... monitors the early onset of tooth decay without ... of invasive and painful procedures,and encourages better oral ...
... climate change places 1.7,billion people - 25% of ... warns,anti-poverty agency ActionAid., WASHINGTON, July 2 ... ActionAid launches a new report, "Cereal,Offenders: How the ... and What,They Can Do to Stop It." Read ...
... 2 Regarding the completely fabricated,item about GO3 ... July 14, 2008,edition of Star magazine, none of ... were contacted by the magazine prior to publication., ... reviewing its legal options and will vigorously pursue ...
... Jr,Washington Wizards Guard and Washington, DC native, will ... July 29 featuring bowling at Lucky Strike in,Chinatown. ... support the,cause, including Brendan Haywood and DeShawn Stevenson, ... Vince Carter, Kevin Durant, and,Chris Bosh. Additionally, Craig ...
... individual patients, study says , , WEDNESDAY, July 2 (HealthDay News) ... cells in the blood of lung cancer patients may make ... the genetic "signature" of particular tumors but to monitor changes ... think this is key to personalized medicine," said Dr. Daniel ...
... sports medicine specialist, John Albright, MD, will join three other physicians ... of Fame inductee. , ... Orlando, Florida (PRWEB) July ... MD, will join three other physicians as a 2008 American ...
Cached Medicine News:Health News:Breakthrough Technology That Will Revolutionize the Treatment of Tooth Decay 2Health News:Breakthrough Technology That Will Revolutionize the Treatment of Tooth Decay 3Health News:ActionAid Challenges G8 on Response to Food Crisis 2Health News:GO3 Statement Regarding Erroneous Coverage in Star Magazine 2Health News:Washington Wizards Guard Roger Mason Jr. to Host Bowling at Lucky Strike to Benefit National Kidney Foundation of the National Capital Area 2Health News:Circulating Tumor Cells Reveal Insights Into Lung Cancers 2Health News:Circulating Tumor Cells Reveal Insights Into Lung Cancers 3Health News:Renowned Iowa Orthopaedic Surgeon, John Albright, MD, Inducted into Sports Medicine Hall of Fame 2Health News:Renowned Iowa Orthopaedic Surgeon, John Albright, MD, Inducted into Sports Medicine Hall of Fame 3
(Date:1/15/2014)... , Jan. 15, 2014 ... research report is available in its ... Markets and Technologies for Advanced Drug ... of Administration ...
(Date:1/15/2014)... 15, 2014  A novel wearable injector slightly larger than an ... patients to self-inject prescription drugs in the large doses required ... diseases, autoimmune deficiencies, and genetic disorders.  An ... by 2018, according to analysts.   Many of these drugs will ...
(Date:1/14/2014)... Texas , Jan. 14, 2014  Luminex Corporation (Nasdaq: ... results for the fourth quarter of 2013 on Monday, February ... for release after the close of trading. ... conference call to discuss the operating highlights and financial results ...
Breaking Medicine Technology:Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 16Enable Injections Presents A New Class of Injectors for Drug Delivery at PEPTalk, Drug Delivery Partnership Meetings 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: