Navigation Links
JCI online early table of contents: May 17, 2010
Date:5/10/2010

n tumor patients also targeted these proteins. As this method is fast and inexpensive, the authors hope that it will be suitable for identifying candidate tumor proteins to develop individualized cancer immunotherapies.

TITLE: Rapid T cellbased identification of human tumor tissue antigens by automated two-dimensional protein fractionation

AUTHOR CONTACT:
Christel Herold-Mende
University of Heidelberg, Germany.
Phone: 49.6221.566405; Fax: 49.6221.565362; E-mail: H.Mende@med.uni-heidelberg.de.

View this article at: http://www.jci.org/articles/view/37646?key=b7e528440941c5a0fa90


INFLAMMATION: Learning our A, P, C's in sepsis

Sepsis is a life-threatening condition characterized by a whole-body inflammatory response. In some instances, patients with sepsis are treated with activated protein C (APC). APC is best known for its role as a negative regulator of blood clotting, which it mediates by binding to the protein EPCR. In contrast, the mechanism(s) by which APC mediates its anti-inflammatory effect to benefit individuals with sepsis has not been determined. However, Li Zhang and colleagues, at the University of Maryland School of Medicine, Baltimore, have now determined that the anti-inflammatory effects of APC in mice occur via a molecular pathway initiated upon APC interaction with the CD11b/CD18 protein complex. Furthermore, the pathway activated by this interaction reduced mortality in a mouse model of lethal sepsis. Additional in vitro and in vivo analyses indicated that the anti-inflammatory function of APC is distinct from its function as a negative regulator of blood clotting.

TITLE: The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b

AUTHOR CONTACT:
Li Zhang
University of Maryland School o
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. A medicine classic goes online and far afield
2. New Online Service Helps Patients Find Info on Pricing, Financial Assistance
3. Horizon Display Demonstrates their Dedication to After-Sales Support with Enhanced Online Resources
4. CareData Introduces Online Electronic Health Record Training Course for Allied Health Paraprofessionals
5. LeveragePoint Releases Complete Online Value Management Solution
6. SeaShine, LLC Announces the Launch of SeaShine Online Magazine, a Magazine for Women Who Positively Impact their Communities through Transparent Lifestyles
7. Leveragepoint Names Jay Manson Vice President Sales For Online Value Management Tools
8. Prize4Life Launches “Art, Life, Spring” Online Art Auction to Raise Funds for Lou Gehrig's Disease Research
9. ShenoaDiamonds.com Holds Contest to Give Away $5,000 Diamond Ring, Spurred by Online Sales Growth
10. New Online Stores & Online Shopping Collection Web Site
11. The Diet Solution Program: Popular Online Weight Loss Program is Revised to Include More Metabolism Boosting Meals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... University School of Medicine researchers have been awarded two-year ... Novo Nordisk announced this month. Of the 110 initial ... Biologics Science Forum Program, only four projects were funded, ... They are Jonathan Powell, M.D., Ph.D.; G. William Wong, ... Powell, a professor of oncology, will use his $500,000 ...
(Date:4/18/2014)... Fraser University psychologists have made a brain-related discovery ... attention-deficit disorders. , This discovery opens up the ... or suppress a specific brain activity that the ... , The Journal of Neuroscience has ... John McDonald, an associate professor of psychology and ...
(Date:4/18/2014)... to potential new treatments for breaking the cycle of ... or scarring, is a hallmark of the disease, and ... to serious organ damage and, in some cases, death. ... findings made by Swati Bhattacharyya, PhD, research assistant professor ... protein plays in promoting fibrosis. , "Our results ...
(Date:4/17/2014)... identified the first genetic variant specifically associated with ... for around 10-15 per cent of all breast ... the breast cancer sub-type, called invasive lobular carcinoma, ... of this particular kind of breast cancer, which ... published today (Thursday) in the journal PloS ...
(Date:4/17/2014)... today in PLOS Pathogens , children who live ... can mount an immune response to infection with malaria ... of high fever and illness and partially control the ... may help researchers develop future interventions that prevent or ... Each year, approximately 200 million cases of malaria occur ...
Breaking Medicine News(10 mins):Health News:Scientists discover brain's anti-distraction system 2Health News:New clues on tissue scarring in scleroderma 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3Health News:Study sheds light on how the immune system protects children from malaria 2
... 23 (HealthDay News) -- Implantable devices designed to ... death among heart failure patients are as effective ... they are in controlled study environments, new research ... analysis of nearly 186,000 patients outfitted with either ...
... Richmond, Va. (Nov. 22, 2010) Researchers at Virginia ... for its involvement in tumor cell development, growth and ... chemotherapy. By inhibiting the expression of this gene, doctors ... treating aggressive cancers such as breast, liver and prostate ...
... Elderly adults can improve their vision with perceptual training, according ... Boston University that has implications for the health and mobility ... improved visual performance in early stages of visual processing," appears ... Vision . It was funded by a $3.5 million grant ...
... News) -- Increased efforts to prevent several lifestyle-related diseases ... year in medical costs, researchers say. Using 2003-2005 ... estimated how reductions in the rates of diabetes, high ... spending. The findings were released online Nov. 18 ...
... HealthDay Reporter , MONDAY, Nov. 22 (HealthDay ... therapy with either warfarin or a combination of Plavix ... Both therapies are prescribed for millions of Americans ... attack or stroke. But the Plavix-aspirin combination was thought ...
... and droplets are the primary ways influenza spreads. ... In a study published in the current issue ... ( http://www.journals.uchicago.edu/doi/abs/10.1086/656743 ), the authors examined such an ... On April 4, 2008, seven inpatients in ...
Cached Medicine News:Health News: Implanted Heart Devices Have 'Real-World' Benefits: Study 2Health News: Implanted Heart Devices Have 'Real-World' Benefits: Study 3Health News:New function of gene in promoting cancer found by VCU researchers 2Health News:Perceptual training improves vision of the elderly 2Health News:Disease Prevention Could Save U.S. Billions of Dollars Annually 2Health News: Bleeding Risk With Plavix-Aspirin Regimen May Be Serious 2Health News: Bleeding Risk With Plavix-Aspirin Regimen May Be Serious 3
(Date:1/15/2014)... , Jan. 15, 2014 Most osteoporosis patients ... to a recent online survey* sponsored by Mission Pharmacal ... the National Osteoporosis Foundation online support community, revealed that ... medication that comes in a form other than a ...
(Date:1/15/2014)... Jan. 15, 2014  Celsion Corporation (the "Company") (NASDAQ: ... from institutional investors to purchase an aggregate of approximately ... at-the-market registered direct offering, led by a dedicated health ... purchase agreements with these investors pursuant to which the ...
(Date:1/15/2014)...  Manufacturers, suppliers and distributors of innovative medical-related products ... most important business assets, intellectual property (IP). ... Because of the highly-competitive nature of the Medical ... most litigious industry sectors of cases involving IP ...
Breaking Medicine Technology:Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3Intellectual Property Insurance for Medical-related Products and Services 2
... CITY, Feb. 21, 2012 Genomma Lab Internacional, S.A.B. de ... a non-binding proposal to acquire all of the outstanding shares ... ) common stock for $16.60 dollars per share in cash. ... including Prestige,s net debt. Genomma,s all-cash proposal ...
... Corporation (NYSE: SHP ) ("ShangPharma" or the ... development outsourcing company, today announced that it will attend ... in Boston, Massachusetts from March 5-7, 2012. ... Relations of ShangPharma, will present at the conference and ...
Cached Medicine Technology:Genomma Lab Internacional Announces Non-binding Proposal to Acquire Prestige Brands Holdings for $16.60 Per Share in Cash 2Genomma Lab Internacional Announces Non-binding Proposal to Acquire Prestige Brands Holdings for $16.60 Per Share in Cash 3Genomma Lab Internacional Announces Non-binding Proposal to Acquire Prestige Brands Holdings for $16.60 Per Share in Cash 4Genomma Lab Internacional Announces Non-binding Proposal to Acquire Prestige Brands Holdings for $16.60 Per Share in Cash 5
... Bird and Cronin, Inc. ... of Patient Footwear, Orthopedic ... Care Products. Our products ... quality and available in ...
... AliMed® Turnbuckle Ankle Orthosis enables ... torque at the ankle joint to ... The splint features a pair of ... and eversion/inversion simultaneously. Simply adjust the ...
Softsplint after bunion surgery. Hook-and-loop closure. Maintains hallux positioning and metatarsophalangeal alignment. Washable....
... vein thrombosis, the Aircast VenaFlow System uses ... and rapid impulse inflation. This combination helps ... while producing more shear stress to enhance ... tube assembly (cuffs are sold separately). The ...
Medicine Products: