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JCI online early table of contents: May 17, 2010
Date:5/10/2010

n tumor patients also targeted these proteins. As this method is fast and inexpensive, the authors hope that it will be suitable for identifying candidate tumor proteins to develop individualized cancer immunotherapies.

TITLE: Rapid T cellbased identification of human tumor tissue antigens by automated two-dimensional protein fractionation

AUTHOR CONTACT:
Christel Herold-Mende
University of Heidelberg, Germany.
Phone: 49.6221.566405; Fax: 49.6221.565362; E-mail: H.Mende@med.uni-heidelberg.de.

View this article at: http://www.jci.org/articles/view/37646?key=b7e528440941c5a0fa90


INFLAMMATION: Learning our A, P, C's in sepsis

Sepsis is a life-threatening condition characterized by a whole-body inflammatory response. In some instances, patients with sepsis are treated with activated protein C (APC). APC is best known for its role as a negative regulator of blood clotting, which it mediates by binding to the protein EPCR. In contrast, the mechanism(s) by which APC mediates its anti-inflammatory effect to benefit individuals with sepsis has not been determined. However, Li Zhang and colleagues, at the University of Maryland School of Medicine, Baltimore, have now determined that the anti-inflammatory effects of APC in mice occur via a molecular pathway initiated upon APC interaction with the CD11b/CD18 protein complex. Furthermore, the pathway activated by this interaction reduced mortality in a mouse model of lethal sepsis. Additional in vitro and in vivo analyses indicated that the anti-inflammatory function of APC is distinct from its function as a negative regulator of blood clotting.

TITLE: The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b

AUTHOR CONTACT:
Li Zhang
University of Maryland School o
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Journal of Clinical Investigation
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