Navigation Links
JCI online early table of contents: May 17, 2010
Date:5/10/2010

have identified the protein SIPL1 as a negative regulator of PTEN in human cancer cells. Of clinical relevance, SIPL1 was expressed at higher levels in human cervical cancer tissue expressing the PTEN protein than in human cervical cancer tissue lacking PTEN, and this coexpression was associated with reduced PTEN activity. These observations, together with data from several xenograft tumor models, lead the authors to suggest that SIPL1 contributes to PTEN inactivation during the formation and growth of some tumors.

TITLE: Shank-interacting proteinlike 1 promotes tumorigenesis via PTEN inhibition in human tumor cells

AUTHOR CONTACT:
Damu Tang
St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada.
Phone: 905.522.1155, ext. 35168; Fax: 905.540.6549 or 905.521.6181; E-mail: damut@mcmaster.ca.

View this article at: http://www.jci.org/articles/view/40778?key=87ba058de8cc3ba82cce


TUMOR IMMUNOLOGY: Directing immune destruction of tumors

Immunotherapeutic approaches to treating cancer hold a lot of promise, but clinical results thus far have been disappointing. Identifying the proteins expressed by an individual's cancer that are most likely to trigger that individual's immune system to attack are thought likely to enhance the efficacy of cancer immunotherapies. However, current techniques do not efficiently identify such proteins.

But now, a team of researchers, led by Christel Herold-Mende, at the University of Heidelberg, Germany, has developed a new method of comprehensively identifying candidate tumor proteins that spontaneously trigger immune responses. Applying this method, the authors identified two tumor proteins that were targeted by the immune system of a patient with a malignant brain tumor and found that the immune system of 4 of 10 other brai
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. A medicine classic goes online and far afield
2. New Online Service Helps Patients Find Info on Pricing, Financial Assistance
3. Horizon Display Demonstrates their Dedication to After-Sales Support with Enhanced Online Resources
4. CareData Introduces Online Electronic Health Record Training Course for Allied Health Paraprofessionals
5. LeveragePoint Releases Complete Online Value Management Solution
6. SeaShine, LLC Announces the Launch of SeaShine Online Magazine, a Magazine for Women Who Positively Impact their Communities through Transparent Lifestyles
7. Leveragepoint Names Jay Manson Vice President Sales For Online Value Management Tools
8. Prize4Life Launches “Art, Life, Spring” Online Art Auction to Raise Funds for Lou Gehrig's Disease Research
9. ShenoaDiamonds.com Holds Contest to Give Away $5,000 Diamond Ring, Spurred by Online Sales Growth
10. New Online Stores & Online Shopping Collection Web Site
11. The Diet Solution Program: Popular Online Weight Loss Program is Revised to Include More Metabolism Boosting Meals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... CRDF Global released today its ... edition – rich with videos, images and interactive ... Global empowers scientists and innovators around the world. ... foundation and individual supporters, CRDF Global reaches across ... training and entrepreneurship. , The Annual Report highlights ...
(Date:9/18/2014)... 18, 2014 Phela Health and Wellness ... HABIT™ Program in South Africa. HABIT™ is a ... and distributed in South Africa by Bestflex. , Phela ... which has been tailored to address issues that are ... behavior modification and chronic disease prevention. This solution combines ...
(Date:9/18/2014)... 2014) A new expert panel report, Improving ... the Council of Canadian Academies, addresses the importance ... Each year about half of Canada,s seven million ... of this prescribing is done off-label (i.e. the ... health risks., Children have historically been excluded in ...
(Date:9/18/2014)... Dr. Andrea Basile, MD, one of the most ... at Basile Plastic Surgery to include Coolsculpting. This non-invasive technique ... in the world for the removal of fat because of ... Dr. Basile, Coolsculpting will greatly benefit those patients with body ... procedure. He also said this procedure is ideal for people ...
(Date:9/18/2014)... 18, 2014 The new BuildClean™ ... to contractors and homeowners alike as it eliminates ... the home, causes potential health issues, and makes ... the BuildClean system allows contractors to virtually eliminate ... other standard remodeling tasks. , BuildClean removes up ...
Breaking Medicine News(10 mins):Health News:CRDF Global Launches Media-Rich Digital Edition of Annual Report, Tells Story of Empowering Scientists and Innovators around the World in 2013 2Health News:Improving medicines for children in Canada 2Health News:Naples Plastic Surgeon Introduces Pain-free Fat Removal Technique 2Health News:Naples Plastic Surgeon Introduces Pain-free Fat Removal Technique 3Health News:New BuildClean™ System Brings Livability Back to Home Remodeling 2Health News:New BuildClean™ System Brings Livability Back to Home Remodeling 3Health News:New BuildClean™ System Brings Livability Back to Home Remodeling 4
... Research Group is,an exciting newcomer in the field ... information service established to,provide the general public with ... choose for a variety of medical problems resulting ... the website will be,obtained through an online survey ...
... of the,Board and Chief Executive Officer, A.G. Lafley, addressed ... at its annual meeting today. Lafley,said, "P&G is a ... long term,-- consistently, reliably and sustainably." Growth in ... fiscal 2007. P&G increased,net sales by 12 percent to ...
... UPCARE(R) E2E, an end-to-end, financial and clinical ... for laboratories. -- ... Mich., Oct. 9 Today, UPCARE Technology, Inc.,unveiled its new ... part on the success of its parent company, Marquette,General Health ...
... three scientists receiving the 2007 Nobel Prize for Physiology or ... their careers, bringing to 42 the number of Nobel Laureates ... Capecchi, Ph.D. of the University of Utah and Oliver Smithies, ... with Sir Martin J. Evans of Cardiff University in Wales ...
... Nutrition,(OTC Bulletin Board: NNTN) http://www.interactivenutrition.com will ... 2007 at,11:00 a.m. Eastern time. U.S. and Canadian ... 800-750-4065 and International Shareholders may dial in at,404-920- ... 767872#. Executives,from Natural Nutrition will be available for ...
... Exchange Symbol: AKL, MONTREAL, Oct. 9 /PRNewswire-FirstCall/ ... company focused on developing therapies for the,inhalation, pain ... 2007, its issued and outstanding common shares will ... common share for every seven (7),pre-consolidation common shares. ...
Cached Medicine News:Health News:Nursesavvy.com Promoting Quality Healthcare for Everyone 2Health News:Lafley Tells Shareholders That 'P&G is Designed to Grow' 2Health News:Lafley Tells Shareholders That 'P&G is Designed to Grow' 3Health News:Lafley Tells Shareholders That 'P&G is Designed to Grow' 4Health News:Lafley Tells Shareholders That 'P&G is Designed to Grow' 5Health News:Lafley Tells Shareholders That 'P&G is Designed to Grow' 6Health News:UPCARE Technology to Share the Secrets of its Parent's Success in Lab Outreach 2Health News:UPCARE Technology to Share the Secrets of its Parent's Success in Lab Outreach 3Health News:UPCARE Technology to Share the Secrets of its Parent's Success in Lab Outreach 4Health News:Natural Nutrition to Hold International Shareholder Conference Call Thursday, October 11, 2007 at 11:00 a.m. Eastern Time 2Health News:Akela Pharma Inc. Completes Share Consolidation 2
(Date:9/18/2014)... and MELBOURNE, Australia , ... Nexvet Biopharma today announced the appointments of Dr. ... McCracken D.V.M ., M.S., to its Board of Directors. ... Medical Affairs Finance at Genentech and Chief Financial Officer ... served as Vice President and Global Head of Business ...
(Date:9/18/2014)... JOLLA, Calif. , Sept. 18, 2014 /PRNewswire/ ... RGLS ), a biopharmaceutical company leading the discovery ... today it has initiated its ATHENA natural history ... a life-threatening genetic kidney disease with no approved ... the natural decline of renal function markers such ...
(Date:9/18/2014)... days before the government of Sierra Leone ... Ebola, World Vision will begin a massive delivery of 200 ... McKesson, the largest healthcare services company in ... Medical-Surgical donated four million pairs of latex gloves – enough ... needs for the next five months* – to ...
Breaking Medicine Technology:Nexvet Appoints Ashraf Hanna and Joseph McCracken to Board of Directors 2Nexvet Appoints Ashraf Hanna and Joseph McCracken to Board of Directors 3Regulus Initiates ATHENA Natural History of Disease Study in Alport Syndrome Patients 2Regulus Initiates ATHENA Natural History of Disease Study in Alport Syndrome Patients 3Regulus Initiates ATHENA Natural History of Disease Study in Alport Syndrome Patients 4Regulus Initiates ATHENA Natural History of Disease Study in Alport Syndrome Patients 5Regulus Initiates ATHENA Natural History of Disease Study in Alport Syndrome Patients 6World Vision, McKesson, Other Donors Prepare for Massive Shipment of Medical Supplies to Support Sierra Leone Health Workers 2World Vision, McKesson, Other Donors Prepare for Massive Shipment of Medical Supplies to Support Sierra Leone Health Workers 3World Vision, McKesson, Other Donors Prepare for Massive Shipment of Medical Supplies to Support Sierra Leone Health Workers 4
... N.C., Feb. 10, 2011 For the biopharmaceutical ... importance - and difficulty - of interacting with ... restrictions have created both opportunities and challenges for ... control. To help marketing teams in ...
... 3-V Biosciences, Inc. announced today Stephen R. Brady has ...   http://photos.prnewswire.com/prnh/20100513/LA04336LOGO ) "Steve,s contributions have been pivotal ... 3-V," said Merdad V. Parsey, MD, PhD, 3-V,s Chief Executive ... continue to build the 3-V team and advance the company,s ...
Cached Medicine Technology:Innovations in Patient-Focused Initiatives to Improve Outcomes 23-V Biosciences Promotes Stephen R. Brady to Chief Business Officer 2
BioScrew® Bio-Absorbable Interference Screws and Delivery System Clinically equivalent to metal interference screws....
... Interference Screws. Optimal screw ... graft selection options. Robust ... deformation, and chamfered screw ... atraumatic tissue fixation. Features ...
Cannulated Interference Screws...
... on the TrueView II design, a new ... for small joint arthroscopy is available. The ... very durable thanks to Olympus advanced fibre ... class means bright images, brilliant colour reproduction, ...
Medicine Products: