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JCI online early table of contents: May 17, 2010
Date:5/10/2010

have identified the protein SIPL1 as a negative regulator of PTEN in human cancer cells. Of clinical relevance, SIPL1 was expressed at higher levels in human cervical cancer tissue expressing the PTEN protein than in human cervical cancer tissue lacking PTEN, and this coexpression was associated with reduced PTEN activity. These observations, together with data from several xenograft tumor models, lead the authors to suggest that SIPL1 contributes to PTEN inactivation during the formation and growth of some tumors.

TITLE: Shank-interacting proteinlike 1 promotes tumorigenesis via PTEN inhibition in human tumor cells

AUTHOR CONTACT:
Damu Tang
St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada.
Phone: 905.522.1155, ext. 35168; Fax: 905.540.6549 or 905.521.6181; E-mail: damut@mcmaster.ca.

View this article at: http://www.jci.org/articles/view/40778?key=87ba058de8cc3ba82cce


TUMOR IMMUNOLOGY: Directing immune destruction of tumors

Immunotherapeutic approaches to treating cancer hold a lot of promise, but clinical results thus far have been disappointing. Identifying the proteins expressed by an individual's cancer that are most likely to trigger that individual's immune system to attack are thought likely to enhance the efficacy of cancer immunotherapies. However, current techniques do not efficiently identify such proteins.

But now, a team of researchers, led by Christel Herold-Mende, at the University of Heidelberg, Germany, has developed a new method of comprehensively identifying candidate tumor proteins that spontaneously trigger immune responses. Applying this method, the authors identified two tumor proteins that were targeted by the immune system of a patient with a malignant brain tumor and found that the immune system of 4 of 10 other brai
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Contact: Karen Honey
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Journal of Clinical Investigation
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