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JCI online early table of contents: May 17, 2010
Date:5/10/2010

cles/view/40141?key=dc42b930fbb1a36725f5">http://www.jci.org/articles/view/40141?key=dc42b930fbb1a36725f5


GASTROENTEROLOGY: Reducing colon cancer risk in a model of inflammatory bowel disease

Individuals with inflammatory bowel disease (IBD) have an increased risk of developing colon cancer because of the chronic inflammation in their guts. A potential new therapeutic approach to reducing this risk has now been suggested by Deborah Rubin and colleagues, at Washington University School of Medicine, Saint Louis, as a result of their work in a mouse model of IBD-induced colon cancer.

In the study, they find that mice lacking the protein epimorphin are protected from inflammation-induced colon cancer, likely as a result of increased repair of the lining of the gut and decreased levels of the proinflammatory factor IL-6. They therefore suggest that modulating epimorphin levels may have therapeutic benefits and help protect individuals with IDB from going on to develop colon cancer.

TITLE: Epimorphin deletion protects mice from inflammation-induced colon carcinogenesis and alters stem cell niche myofibroblast secretion

AUTHOR CONTACT:
Deborah C. Rubin
Washington University School of Medicine, Saint Louis, Missouri, USA.
Phone: 314.362.8935; Fax: 314.362.8959; E-mail: drubin@wustl.edu.

View this article at: http://www.jci.org/articles/view/40676?key=a68a794497995c07a248


ONCOLOGY: COMManDing a role in tumor invasion

Little is known about the function of the COMMD family of proteins. However, a team of researchers, at the University of Texas Southwestern Medical Center, Dallas, and University Medical Centre Maastricht, The Netherlands, has now found that COMMD1, the prototypic member of the COMMD family, has a role in tumor inva
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Contact: Karen Honey
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Journal of Clinical Investigation
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