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JCI online early table of contents: May 1, 2009
Date:5/1/2009

oimmune diseases, multiple sclerosis and type 1 diabetes, mice with T cells that lacked Bim were observed to be protected from disease. In vitro analysis indicated that following stimulation, T cells lacking Bim were impaired in their ability to produce soluble factors known as cytokines (molecules that execute T cell effects). At the molecular level, Bim was shown to control T cell activation via an IP3R/calcium/NFAT pathway. As the authors point out, this study reveals that Bim joins a growing list of proteins with dual roles in T cell activation and death.

TITLE: Critical roles of Bim in T cell activation and T cellmediated autoimmune inflammation in mice

AUTHOR CONTACT:
Youhai H. Chen
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Phone: (215) 898-4671; Fax: (215) 573-3434; E-mail: yhc@mail.med.upenn.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=37619


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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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