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JCI online early table of contents: May 1, 2009
Date:5/1/2009

have now determined that Fog2 regulates adult mouse heart function and the growth of new coronary vessels.

The authors generated mice lacking Fog2 in heart muscle cells either early or late in embryonic heart development. As has been observed for mice lacking Fog2 in all cells from the point of conception, mice in which Fog2 was deleted early in heart development died before birth, with the same heart and coronary vessel defects. By contrast, mice in which Fog2 was deleted later in heart development survived until 8󈝺 weeks after birth. However, these mice had decreased heart function and insufficient coronary vessels, which led to a lack of oxygen passing to the heart muscle cells and thereby death of the cells and scarring of the heart muscle. These data indicate that Fog2 is required for maintaining heart and coronary vessel function in the adult mouse heart.

TITLE: Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart

AUTHOR CONTACT:
William T. Pu
Children's Hospital Boston, Boston, Massachusetts, USA.
Phone: (617) 919-2091; Fax: (617) 730-0140; E-mail: wpu@enders.tch.harvard.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=38723


AUTOIMMUNITY: Two opposing roles for the protein Bim: control of T cell activation and death

The protein Bim has previously been shown to have a role in the cellular process that kills developing T cells (a subset of immune cells) that are 'born' with the ability to attack the body's own tissues and cause autoimmune diseases. Surprisingly, Youhai Chen and colleagues, at University of Pennsylvania School of Medicine, Philadelphia, have now found that Bim also has a role in controlling the activation of mouse T cells.

In the study, in mouse models of two aut
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Contact: Karen Honey
press_releases@the-jci.org
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Journal of Clinical Investigation
Source:Eurekalert

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