Navigation Links
JCI online early table of contents: May 1, 2009
Date:5/1/2009

EDITOR'S PICK: Now we know what blocks the effects of a newly developed anticancer therapy

A new approach being developed to treat individuals with cancer that is resistant to standard therapy is the use of adenovirus-based therapies. Although promising clinical results have been obtained in some settings, in many cases the therapies have had little impact. One reason for this lack of efficacy has now been uncovered by a team of researchers, led by Nick Lemoine and Yahoe Wang, at Barts and The London School of Medicine and Dentistry, London.

In the study, they found that human pancreatic cancer cell lines expressing the protein CEACAM6 were not sensitive to being killed by adenoviruses. Further analysis revealed the molecular mechanism by which CEACAM6 mediates its effects and indicated that knocking down expression of CEACAM6 markedly increased the anticancer effects of an adenovirus in mice harboring human tumor cells. The authors therefore suggest that identifying whether or not a tumor expresses CEACAM6 and the downstream proteins required to block tumor cell killing by adenoviruses might provide a way to predict the response of patients to adenovirus-based therapies, and that these proteins might provide targets for the development of more effective adenovirus-based therapies.

TITLE: CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells

AUTHOR CONTACT:
Nick Lemoine
Institute of Cancer, Barts and The London School of Medicine and Dentistry, London, United Kingdom.
Phone: 44-20-70140420; Fax: 44-20-70140431. E-mail: nick.lemoine@cancer.org.uk.

Yaohe Wang
Institute of Cancer, Barts and The London School of Medicine and Dentistry, London, United Kingdom.
Phone: 44-20-70140445; Fax: 44-20-70140431. E-mail: yaohe.wang@cancer.org.uk.

View the PDF of t
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. ScienceRoll.com On How to Follow Swine Flu Information Online
2. Medifecta Healthcare Training Launches Website with Educational Resources and Online Training for Caregivers
3. Medeguide Announces Online Marketing Partnership with Admax Plus to Promote Doctors and Treatment Packages Online
4. RightSignature Announces Beta Launch of Breakthrough Online Document Signing Service
5. Penn Foster Career School Launches Online Certified Personal Trainer Program
6. Copper Conferencing Announces Dr. Joy Ohayia Kicks Off the Women In Business Track of The Business Webinar Series - A Free Online Learning Series for Business Professionals
7. PeopleStreme Releases RapidEcho Online Tool for Employee Personal Development
8. Tennenbaum Encourages Shareholders to Vote the Blue Proxy for Tennenbaum Director Nominees at Online Resources Annual Meeting as Recommended by Riskmetrics/ISS and Proxy Governance
9. Thomson Reuters and the National Foundation for Cancer Research Provide Online Help for Cancer Patients
10. Video: Adults Facing ADHD: ADHD Allies(TM) Offers Unique Online Community for Adults with ADHD on New Facebook(R) Page
11. IOUSOS™ Launches Online Consumer Medical Bill Clearinghouse: New Service Set to Help More than 50 Million Americans and Healthcare Providers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2015)... 27, 2015 Today, February 27th, is "Shine ... , along with LXR Organics and Living ... Campaign to raise awareness and promote prevention, rescue and restoration ... by the END IT Coalition, slavery is the 2nd largest ... exists in 167 countries around the world. Slavery includes bonded ...
(Date:2/27/2015)... Laguna Hills, CA (PRWEB) February 27, 2015 ... & Wolf, LLP (BPW) has been chosen as their ... Microsoft Dynamics GP, CRM and other complimentary solutions for ... expertise in working with credit unions. Altec and BPW ... processes leveraging doc-link’s integration to Dynamics GP. , “We ...
(Date:2/27/2015)... In honor of American Heart Month in February, Dr. Edwin Scott, ... tips on how to improve heart health. , Heart disease may ... have to accept it as their fate. Although one may lack ... history, sex or age — there are some key heart disease ... tips to improve heart health and prevent heart disease: , 1. ...
(Date:2/27/2015)... The V Foundation for Cancer Research, one ... excited to announce numerous promotions taking place this March. ... partnerships highlight The V Foundation’s significant work in the ... all to get involved. Awarding 100 percent of ... V Foundation has funded more than $130 million in ...
(Date:2/27/2015)... Mequon, Wisconsin (PRWEB) February 27, 2015 ... facial plastic surgeons , is pleased to announce the ... location now open in Delafield. Quintessa has begun seeing ... Campbell, the new Delafield location will offer a variety ... patients, including: Botox, filler injectables, micro laser peels, chemical ...
Breaking Medicine News(10 mins):Health News:KAJ Brothers Join the Campaign to 'End It - Shine A Light On Slavery' 2Health News:Altec Announces 2014 doc-link for Dynamics Partner of the Year Award Recipient 2Health News:Altec Announces 2014 doc-link for Dynamics Partner of the Year Award Recipient 3Health News:Center for Primary Care Celebrates American Heart Month 2Health News:Center for Primary Care Celebrates American Heart Month 3Health News:Center for Primary Care Celebrates American Heart Month 4Health News:The V Foundation Reinforces its Fight Against Cancer with New and Extended Partnerships 2Health News:The V Foundation Reinforces its Fight Against Cancer with New and Extended Partnerships 3Health News:Dr. Andrew Campbell Expands Quintessa Aesthetic Center into Delafield 2Health News:Dr. Andrew Campbell Expands Quintessa Aesthetic Center into Delafield 3
... ... could barely keep up with demand to sample and learn about their new products at ... entire day. , ... TX (PRWEB) June 24, 2009 -- Bariatric Advantage, a Division of Catalina Lifesciences, could barely ...
... , Businesses Support Private Insurance Over Federal Plan, Oppose Mandates ... are ready for major changes to the American health care ... proposals to help them cope with the costs. When asked ... of micro-business owners cited cost containment, even over access and ...
... Orthopedic Group, Inc. (NYSE: HGR ) announced today that ... of operations for the second quarter ending June 30, 2009, on ... , , The conference call is scheduled to begin at ... participate should call 1-800-931-9710. In addition, a replay will be available ...
... Medical Systems (NYSE: VAR ) announced today that it ... the close of regular trading on Wednesday, July 29, 2009. ... all interested parties at 2:00 p.m. PT. The news release and ... company website at : www.varian.com/investor ...
... Makes Treatment More Affordable to Pet Owners , ... pharmaceutical company focused on the development of generic drugs ... version of the canine medication Rimadyl(R) caplets. Putney,s carprofen ... less to veterinarians than its branded competitor -- allowing ...
... lower rate of adverse reactions on automated 2-unit red cell ... June 23 Fenwal Inc. announced today it is hosting ... chief medical officer of the American Red Cross, who will ... red cell procedures and manual whole blood collection in young ...
Cached Medicine News:Health News:Interest in the Bariatric Advantage Chewy Bites and Other New Products is at an All-Time High at the ASMBS Conference 2Health News:Micro-Businesses Offer Strong Opinions On Health Reform Proposals 2Health News:Micro-Businesses Offer Strong Opinions On Health Reform Proposals 3Health News:Micro-Businesses Offer Strong Opinions On Health Reform Proposals 4Health News:Varian Medical Systems Schedules Third Quarter FY2009 News Release and Conference Call 2Health News:Putney, Inc. Enters the $175M Annual Veterinary NSAID Market 2Health News:Fenwal to Host Webinar on the Safety of 2-Unit Red Cell Collections From Young Donors 2Health News:Fenwal to Host Webinar on the Safety of 2-Unit Red Cell Collections From Young Donors 3
(Date:2/27/2015)... SAN DIEGO , Feb. 27, 2015 /PRNewswire/ ... three-dimensional biology company focused on delivering breakthrough 3D ... , President and Chief Executive Officer, will present ... "We invite you to join us for ... to provide updates on our commercial launch of ...
(Date:2/27/2015)... , Feb. 27, 2015  Two ... increasing in applications as their effectiveness is ... Kalorama Information.  Kalorama Information says that while ... the most powerful tool in proteomic biomarker ... MS) through its traditional techniques has struggled ...
(Date:2/26/2015)... ITASCA, Ill. , Feb. 26, 2015  Today ... paper, The psychological and physical side effects ... belief that opioid painkillers, such as Vicodin and Oxycontin, ... "More Americans overdose on prescription painkillers than on ... , president and CEO of NSC. "Yet, these medications ...
Breaking Medicine Technology:Organovo Holdings, Inc. to Provide Corporate Update and Investor Presentation in a Live, Interactive Webcast on March 5th 2Organovo Holdings, Inc. to Provide Corporate Update and Investor Presentation in a Live, Interactive Webcast on March 5th 3Organovo Holdings, Inc. to Provide Corporate Update and Investor Presentation in a Live, Interactive Webcast on March 5th 4Report: "Softer" Mass Spec Techniques Gaining Popularity in Biomarker Discovery 2Report: "Softer" Mass Spec Techniques Gaining Popularity in Biomarker Discovery 3National Safety Council: Opioid prescription painkillers have hidden, deadly side effects 2
... , SAN FRANCISCO, Sept. ... today reported long-term data with vicriviroc, its investigational CCR5 ... Phase II VICTOR-E1 study in treatment-experienced HIV-infected patients. ... achieved durable virologic suppression and increased CD4 cell counts, ...
... , , TARRYTOWN, N.Y., ... ) today announced the completion of patient enrollment in two ... the treatment of the neovascular form of age-related macular degeneration ... Trap-Eye: Investigation of Efficacy and Safety in Wet AMD) program, ...
Cached Medicine Technology:Schering-Plough Reports Long-Term Vicriviroc Data From Phase II Open-Label Extension Study in Treatment-Experienced HIV-Infected Patients 2Schering-Plough Reports Long-Term Vicriviroc Data From Phase II Open-Label Extension Study in Treatment-Experienced HIV-Infected Patients 3Schering-Plough Reports Long-Term Vicriviroc Data From Phase II Open-Label Extension Study in Treatment-Experienced HIV-Infected Patients 4Schering-Plough Reports Long-Term Vicriviroc Data From Phase II Open-Label Extension Study in Treatment-Experienced HIV-Infected Patients 5Enrollment Completed in Regeneron and Bayer HealthCare Phase 3 Studies of VEGF Trap-Eye in Neovascular Age-Related Macular Degeneration (Wet AMD) 2Enrollment Completed in Regeneron and Bayer HealthCare Phase 3 Studies of VEGF Trap-Eye in Neovascular Age-Related Macular Degeneration (Wet AMD) 3Enrollment Completed in Regeneron and Bayer HealthCare Phase 3 Studies of VEGF Trap-Eye in Neovascular Age-Related Macular Degeneration (Wet AMD) 4Enrollment Completed in Regeneron and Bayer HealthCare Phase 3 Studies of VEGF Trap-Eye in Neovascular Age-Related Macular Degeneration (Wet AMD) 5
Diagnostic and laboratory test reference. Get help with test preparation, interpretation, follow-up, and reimbursement....
... STELLARA™ is HIPAA-compliant wireless technology ... key hospital departments and personnel a ... in four tages or levels ... of patient care, shorter hospital stays ...
... Focus from Thermo Labsystems was designed specifically ... Advanced features such as the new fast ... on microvolumes help to define this as ... The new interchangeable handle plate offers a ...
... Focus from Thermo Labsystems was designed specifically ... Advanced features such as the new fast ... on microvolumes help to define this as ... The new interchangeable handle plate offers a ...
Medicine Products: