Navigation Links
JCI online early table of contents: May 1, 2009
Date:5/1/2009

EDITOR'S PICK: Now we know what blocks the effects of a newly developed anticancer therapy

A new approach being developed to treat individuals with cancer that is resistant to standard therapy is the use of adenovirus-based therapies. Although promising clinical results have been obtained in some settings, in many cases the therapies have had little impact. One reason for this lack of efficacy has now been uncovered by a team of researchers, led by Nick Lemoine and Yahoe Wang, at Barts and The London School of Medicine and Dentistry, London.

In the study, they found that human pancreatic cancer cell lines expressing the protein CEACAM6 were not sensitive to being killed by adenoviruses. Further analysis revealed the molecular mechanism by which CEACAM6 mediates its effects and indicated that knocking down expression of CEACAM6 markedly increased the anticancer effects of an adenovirus in mice harboring human tumor cells. The authors therefore suggest that identifying whether or not a tumor expresses CEACAM6 and the downstream proteins required to block tumor cell killing by adenoviruses might provide a way to predict the response of patients to adenovirus-based therapies, and that these proteins might provide targets for the development of more effective adenovirus-based therapies.

TITLE: CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells

AUTHOR CONTACT:
Nick Lemoine
Institute of Cancer, Barts and The London School of Medicine and Dentistry, London, United Kingdom.
Phone: 44-20-70140420; Fax: 44-20-70140431. E-mail: nick.lemoine@cancer.org.uk.

Yaohe Wang
Institute of Cancer, Barts and The London School of Medicine and Dentistry, London, United Kingdom.
Phone: 44-20-70140445; Fax: 44-20-70140431. E-mail: yaohe.wang@cancer.org.uk.

View the PDF of t
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. ScienceRoll.com On How to Follow Swine Flu Information Online
2. Medifecta Healthcare Training Launches Website with Educational Resources and Online Training for Caregivers
3. Medeguide Announces Online Marketing Partnership with Admax Plus to Promote Doctors and Treatment Packages Online
4. RightSignature Announces Beta Launch of Breakthrough Online Document Signing Service
5. Penn Foster Career School Launches Online Certified Personal Trainer Program
6. Copper Conferencing Announces Dr. Joy Ohayia Kicks Off the Women In Business Track of The Business Webinar Series - A Free Online Learning Series for Business Professionals
7. PeopleStreme Releases RapidEcho Online Tool for Employee Personal Development
8. Tennenbaum Encourages Shareholders to Vote the Blue Proxy for Tennenbaum Director Nominees at Online Resources Annual Meeting as Recommended by Riskmetrics/ISS and Proxy Governance
9. Thomson Reuters and the National Foundation for Cancer Research Provide Online Help for Cancer Patients
10. Video: Adults Facing ADHD: ADHD Allies(TM) Offers Unique Online Community for Adults with ADHD on New Facebook(R) Page
11. IOUSOS™ Launches Online Consumer Medical Bill Clearinghouse: New Service Set to Help More than 50 Million Americans and Healthcare Providers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... the premier women’s dress supplier, has recently released its ... of AngelWeddingDress.com to find more details. , Many ... a bridal party. AngelWeddingDress offers a variety of gorgeous ... wedding dresses are specially designed for 2015. , AngelWeddingDress ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 A new ... of experience and person-centeredness in the long-term care environment ... action across the continuum. The paper, “The Power of ... engages perspectives and practices of the patient, resident and ...
(Date:1/22/2015)... 2015 For over 20 years, Dr. David Cruz ... Vista area has treated just about every type of injury ... And for those same twenty-plus years, the team at ... injuries with the best possible doctor. With the combined ...
(Date:1/22/2015)... York, NY (PRWEB) January 22, 2015 ... College of Sports Medicine flagship journal Medicine & ... with L-Citrulline before exercise may help reduce gastrointestinal ... exercise. 1 , Participants in the double-blind, ...
(Date:1/22/2015)... IsoComforter, Inc. has introduced the most innovative ... design to treat specific body parts and muscle groups. , ... easy to use patented cold therapy machine with the innovative ... and muscle injuries. IsoComforter has become the industry leader ...
Breaking Medicine News(10 mins):Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2
... a,new online resource for OTC drugs that have no negative side ... to know that non-toxic drugs are available today as,options to successfully ... are able to achieve relief without the adverse side effects,such as ... so many of us. , ...
... Stephen Joffe, Craig Joffe, and,Alan Buckey today filed an ... Exchange Commission. The group previously filed a 13D,disclosing ... LCAV ), which,operates 77 LasikPlus fixed-site laser vision correction ... Joffe is the founder and former Chairman and CEO ...
... did limit vomiting and results are preliminary, researchers ... Children who were given the steroid dexamethasone after ... they also faced an increased risk of bleeding ... early for safety reasons, a new study shows. ...
... inoperable disease, report says , , TUESDAY, Dec. 9 (HealthDay ... have improved overall survival of patients with advanced breast ... review of 128 clinical trials that included more than ... that use of anthracycline regimens led to a 22 ...
... deadliness of Alzheimer,s, report says , , TUESDAY, Dec. 9 ... fail to record severe dementia as a cause of death ... only points to a lack of knowledge about how dementia ... deadly illness, it suggests that deaths due to Alzheimer,s and ...
... for the Prom a Winner, Features Kelli Pedroia , ... Academy of Dermatology has announced that the Melanoma Foundation of New ... given for "significant contributions to the specialty of dermatology." The award ... in March of 2009. , , ...
Cached Medicine News:Health News:New Resource for No Side Effect Drugs 2Health News:LCA-Vision's Former Executive Management Urge Board of Directors to Immediately Call Special Shareholder Meeting to Approve Poison Pill 2Health News:LCA-Vision's Former Executive Management Urge Board of Directors to Immediately Call Special Shareholder Meeting to Approve Poison Pill 3Health News:LCA-Vision's Former Executive Management Urge Board of Directors to Immediately Call Special Shareholder Meeting to Approve Poison Pill 4Health News:LCA-Vision's Former Executive Management Urge Board of Directors to Immediately Call Special Shareholder Meeting to Approve Poison Pill 5Health News:LCA-Vision's Former Executive Management Urge Board of Directors to Immediately Call Special Shareholder Meeting to Approve Poison Pill 6Health News:Steroid After Tonsillectomy Raises Bleeding Risk 2Health News:Steroid After Tonsillectomy Raises Bleeding Risk 3Health News:Non-Hormonal Therapies Aid Breast Cancer Patients 2Health News:Dementia Often Missed as Cause of Death 2Health News:Dementia Often Missed as Cause of Death 3Health News:Melanoma Foundation of New England Wins Gold Triangle Award From the American Academy of Dermatology 2
(Date:1/23/2015)... BOSTON , January 23, 2015 Heptares ... is delighted to announce that the Malcolm Campbell ... Congreve (Vice President of Chemistry), Fiona Marshall ... (Chief Executive Officer and co-founder) for the seminal contributions to ...
(Date:1/22/2015)...  ViewRay™, a privately held medical device company, announced today ... with ITOCHU Corporation (Tokyo Stock Exchange TYO: 8001) to ... of cancer in Japan . ViewRay,s ... and only MRI-guided radiation therapy system that images and ...
(Date:1/22/2015)... UPI ), a medical device company that develops, manufactures ... today reported financial results for the fiscal 2015 third ... the Company,s Urgent ®  PC Neuromodulation System grew 14.5% ... compared to $3.9 million in the third quarter of ...
Breaking Medicine Technology:Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 2Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 4ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2Uroplasty Reports Record Revenue in Fiscal Third Quarter 2Uroplasty Reports Record Revenue in Fiscal Third Quarter 3Uroplasty Reports Record Revenue in Fiscal Third Quarter 4Uroplasty Reports Record Revenue in Fiscal Third Quarter 5Uroplasty Reports Record Revenue in Fiscal Third Quarter 6Uroplasty Reports Record Revenue in Fiscal Third Quarter 7Uroplasty Reports Record Revenue in Fiscal Third Quarter 8Uroplasty Reports Record Revenue in Fiscal Third Quarter 9Uroplasty Reports Record Revenue in Fiscal Third Quarter 10Uroplasty Reports Record Revenue in Fiscal Third Quarter 11Uroplasty Reports Record Revenue in Fiscal Third Quarter 12Uroplasty Reports Record Revenue in Fiscal Third Quarter 13Uroplasty Reports Record Revenue in Fiscal Third Quarter 14Uroplasty Reports Record Revenue in Fiscal Third Quarter 15Uroplasty Reports Record Revenue in Fiscal Third Quarter 16Uroplasty Reports Record Revenue in Fiscal Third Quarter 17Uroplasty Reports Record Revenue in Fiscal Third Quarter 18
... Pharmaceutical Partners, Inc. (Nasdaq: CPRX ) today announced ... version of vigabatrin) for the treatment of cocaine and ... based upon, an in-depth review of the results obtained ... use of CPP-109 for the treatment of cocaine addiction ...
... Blue Belt Technologies, Inc., a Pittsburgh based medical device ... for use in orthopaedic and neurosurgery procedures, has closed ... of financing. The round was led by private ... Innovation Works (Pittsburgh) and consisted of both new investments ...
Cached Medicine Technology:Catalyst Pharmaceutical Partners Continues Clinical Development of CPP-109 For The Treatment of Cocaine and Methamphetamine Addiction 2Catalyst Pharmaceutical Partners Continues Clinical Development of CPP-109 For The Treatment of Cocaine and Methamphetamine Addiction 3Catalyst Pharmaceutical Partners Continues Clinical Development of CPP-109 For The Treatment of Cocaine and Methamphetamine Addiction 4Catalyst Pharmaceutical Partners Continues Clinical Development of CPP-109 For The Treatment of Cocaine and Methamphetamine Addiction 5Catalyst Pharmaceutical Partners Continues Clinical Development of CPP-109 For The Treatment of Cocaine and Methamphetamine Addiction 6Blue Belt Technologies, Inc. Closes Series A Financing 2Blue Belt Technologies, Inc. Closes Series A Financing 3
Acuvue Toric is an exceptionally comfortable soft contact lens made especially for people with astigmatism. The Acuvue Toric lens is designed to comfortably fit the unique shape of your eye....
C 2.3K with lightweight headband: the practical alternative for spectacle-wearers. Delivered in protective designer case....
Easyloupes are exceptional optics that you have come to expect from Oculus. Available in either 1.8x or 2.5x magnification and 40 cm working distance (15.75 inches), they have the well-known durabili...
... Specifically designed for computer operators ... may be placed at different heights ... computer screen. Card is printed two ... and green and uses two type ...
Medicine Products: