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JCI online early table of contents: March 9, 2009
Date:3/9/2009

the protein LDLR and expressing low levels of the receptor for insulin only in the liver developed less severe atherosclerosis than mice lacking LDLR, when fed a Western diet. This is probably because these mice also had reduced levels of the fat transporting molecules VLDL and LDL in the blood. The results of further analysis using additional mouse strains were consistent with the idea that liver cell insulin resistance does not contribute to the development of atherosclerosis in mice, and actually decreases the secretion of VLDL.

TITLE: Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice

AUTHOR CONTACT:
Seongah Han
Department of Medicine, Columbia University, New York, New York, USA.
Phone: (212) 305-4899; Fax: (212) 305-5052; E-mail: sh2068@columbia.edu

View the PDF of this article at: https://www.the-jci.org/article.php?id=36523


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Contact: Brooke Grindlinger
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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