Navigation Links
JCI online early table of contents: March 9, 2009
Date:3/9/2009

ter a heart attack. They found that CaMKII inhibition substantially reduced the expression of inflammatory proteins that are usually upregulated following a heart attack. They report that the expression of one such protein, complement factor B (CFB), is triggered by CaMKII activation during heart attack or exposure to a bacterial endotoxin, and that mice lacking the Cfb gene were partially protected from the adverse consequences of a heart attack. The data suggest that CaMKII is important in regulating inflammatory gene expression following a heart attack.

TITLE: Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart

AUTHOR CONTACT:
Madhu V. Singh
Carver College of Medicine, University of Iowa, Iowa, City, Iowa, USA.
Phone: (319) 335-8954; Fax: (319) 353-5552; E-mail: madhu-singh@uiowa.edu

Mark E. Anderson
Carver College of Medicine, University of Iowa, Iowa, City, Iowa, USA.
Phone: (319) 353-7101; Fax: (319) 353-6343; E-mail: mark-e-anderson@uiowa.edu

View the PDF of this article at: https://www.the-jci.org/article.php?id=35814

STEM CELLS: The protein MuPAR regulates the proliferation and mobilization of blood stem cells

The mechanisms underlying the adhesion and mobilization of hematopoietic stem/progenitor cells (HSPCs), cells that give rise to all other blood cell types, have been poorly understood. Using wild-type and genetically manipulated mice, Peter Carmeliet and his colleagues at Katholieke Universiteit Leuvan, Belgium, reveal in a new study that a membrane-anchored form of the urokinase receptor known as MuPAR is present on a subset of HSPCs and helps maintain this cell population in the bone marrow.

When MuPAR wa
'/>"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

0

GOOD

Page: 1 2 3 4 5

Related medicine news :

1. HIV denialists spread misinformation online -- consequences could be deadly; and more
2. Consequences of online HIV denial; and more
3. Online Epidemic Gives Clues to Bird Flu Spread
4. MedHelp to Add Top Stanford Surgeons and Specialized Forums to Online Health Community
5. Online Celebrity Shoe Charity Auction for Womens Heart Health Opens Bidding
6. Syndicom to Launch Online Community for DePuy Spine
7. Elder Caregiving Site ShirleyBOARD.com Wins WebAward for Outstanding Online Community
8. Peer-Reviewed, Online Database Showcases Local, County and State Pandemic Planning
9. CIGNA Behavioral Health Offers Members Online Provider Profiles
10. Dynamic Energy Systems Goes Online and On-Demand
11. North Shore-LIJ Health System Begins Online Posting of Hospital Infection Rates, Other Performance Information
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... Long-Term Care Insurance shopping site LTC ... which applicants for Long Term Care Insurance are approved by ... The decision to buy a Long Term Care Insurance policy ... able to purchase protection are increasingly being turned away by ... A variety of chronic conditions appear to be responsible ...
(Date:5/23/2013)... Get ready to sweat. , Automatic Body by ... with the Nutrié California Kick Off on ... get the chance to work out with celebrity fitness ... Oz Show, and The Dr. Phil Weight Loss Challenge), ... UFC heavy-weight contender Daniel Cormier at Chukchansi Park in ...
(Date:5/23/2013)... GBI Research’s analysis indicates that the global critical ... number of players accounting for a major proportion of the ... rate between 2006 and 2012, possibly due to the lack ... especially in the US. , GBI Research estimates that ... in 2012, having grown in size at a CAGR of ...
(Date:5/22/2013)... (PRWEB) May 23, 2013 MileageAds.com, an ... official invitation to companies in the Stocks and Bonds ... who choose to advertise with MileageAds will have the ... mediums. , Stocks and bonds companies who accept ... in front of a specific, targeted audience ...
(Date:5/22/2013)... that bicyclists who wear helmets have an 88 percent ... Children,s Hospital found that simply having bicycle helmet laws ... and injuries for children younger than 16 who were ... study, conducted by William P. Meehan III, MD, Lois ... of Boston Children,s Hospital, and Christopher M. Fischer, MD, ...
Breaking Medicine News(10 mins):Health News:More Baby Boomers Rejected by Long Term Care Insurance Companies 2Health News:More Baby Boomers Rejected by Long Term Care Insurance Companies 3Health News:Kim Lyons, Gunter Schlierkamp, & Daniel Cormier To Host Fresno Charity Workout 2Health News:Kim Lyons, Gunter Schlierkamp, & Daniel Cormier To Host Fresno Charity Workout 3Health News:MarketResearch.com Report – Increased Cost of Albumin was Main Factor for Double-Digit Growth of Global Critical Care Market Between 2006 and 2012 2Health News:Mileageads.com Ad Network Now Invites Companies in Stocks and Bonds Services Sector to Advertise on Their Ad Network 2Health News:Rate of bicycle-related fatalities significantly lower in states with helmet laws 2
... SOUTHBURY, Conn., Sept. 21 Karen Powell, founder and CEO ... and second largest interior design franchise, met with members of the ... the franchise industry during the International Franchise Association (IFA) 10th Annual ... , Powell joined 450 franchise leaders from around ...
... FRANKFURT, September 21 Trying economic times mean ... competitve,pressures are making the computer-driven proofreading tool made by,Schlafender ... Schlafender Hase GmbH of Frankfurt reported that an ... (Regulatory,Affairs Professionals Society) in Philadelphia showed they often spend ...
... , FARMINGTON HILLS, Mich., Sept. 21 American ... services in the U.S., announces that 81 clinics have been ... resources, consumer ratings, product review and testimonials for plastic surgeons ... status, 27 American Laser Centers, locations across the country have ...
... ... ... 2009 -- The online Advanced Cardiac Life Support (ACLS) and the Pediatric Advanced Life ... Continuing Education Coordinating Board for Emergency Medical Services (CECBEMS), the national accrediting body for ...
... ... pediatric preparedness is essential , ... Washington, DC (Vocus) September 21, 2009 -- According to a recent IOM report, only 6 ... high rates of novel H1N1 (swine) flu expected this winter, the time to address these ...
... ATLANTA, Sept. 21, Webmedx , the ... a premier supplier of clinical documentation technology, today announced a ... Documentation Platform, QualityAnalytics (TM). QualityAnalytics makes ... types of queries including Medicare,s Recovery Audit Recovery (RAC) program. ...
Cached Medicine News:Health News:Southbury Franchise Industry Leader Urges Congress to Consider Small Businesses in Healthcare Debate 2Health News:Value of Text Verification Tool (TVT) Strongly Confirmed at RAPS in Philadelphia 2Health News:American Laser Centers Wins Platinum, Gold Awards from SignatureForum 2Health News:Health Education Solutions' Advanced Cardiac Life Support and Pediatric Advanced Life Support Courses Receive Accreditation 2Health News:Health Education Solutions' Advanced Cardiac Life Support and Pediatric Advanced Life Support Courses Receive Accreditation 3Health News:Pediatrics: Kids Need Specialized Care in Hospital Emergency Departments 2Health News:Webmedx Launches New Data-Mining Solution for Medical Transcription and Speech-Generated Documents 2
(Date:5/22/2013)... FARMINGTON, Conn. , May 22, 2013 /PRNewswire-iReach/ ... To stay aligned with the latest trends and ... provider that can predict where an industry is ... and evolve. (Photo: http://photos.prnewswire.com/prnh/20130522/CG19099 ) ... in partnership with market research publisher GlobalData, offer ...
(Date:5/22/2013)... and MUNICH , May 22, 2013 /PRNewswire/ ... marketer of transcatheter aortic valve implantation (TAVI) systems for the ... results of the J enaValve Eval U ation of ... Pa T ients with S E vere Ao R tic ... . JUPITER is a post-market registry to evaluate five-year long ...
(Date:5/22/2013)...  Milliman, Inc., a premier global consulting and actuarial ... Medical Index (MMI), which measures the healthcare costs for ... through an employer-sponsored preferred provider organization (PPO) plan. The ... is $22,030. "For the second consecutive ... percentage basis was the lowest in the history of ...
Breaking Medicine Technology:Adapt, React, Evolve: Staying Ahead in the Breast Cancer Gene Testing, Solar Energy, and Oil & Gas Markets with Reliable Analytics and Actionable Insights from GlobalData's 700 Market Analysts 2Adapt, React, Evolve: Staying Ahead in the Breast Cancer Gene Testing, Solar Energy, and Oil & Gas Markets with Reliable Analytics and Actionable Insights from GlobalData's 700 Market Analysts 3Adapt, React, Evolve: Staying Ahead in the Breast Cancer Gene Testing, Solar Energy, and Oil & Gas Markets with Reliable Analytics and Actionable Insights from GlobalData's 700 Market Analysts 4First Results Of The JUPITER Registry On Long Term Performance And Safety Of The Transapical JenaValve TAVI System 2First Results Of The JUPITER Registry On Long Term Performance And Safety Of The Transapical JenaValve TAVI System 3First Results Of The JUPITER Registry On Long Term Performance And Safety Of The Transapical JenaValve TAVI System 4Annual Healthcare Cost for a Typical American Family is $22,030 According to 2013 Milliman Medical Index 2
... Ill., May 13, 2011 Life Spine, a medical ... for the surgical treatment of spine disorders, today announced ... future product offerings and technologies at the 6th Annual ... Thursday, May 12th, 2011, in Napa, California. ...
... Md., May 13, 2011 MedImmune announced today it ... (ATS) International Conference in Denver, CO, May 13-18, 2011. ... our continued commitment to help improve patient health," said ... RIA innovative Medicines Unit (iMED) at MedImmune. ...
Cached Medicine Technology:MedImmune To Present Eight Abstracts on Projects Regarding Thoracic and Respiratory Issues at the Annual American Thoracic Society International Conference 2
... Philadelphia™ Collar and Stabilizer ... posterior reinforcements. Hook-and-pile closure straps. ... and mandibular pieces may be ... attaches easily to the standard ...
Optical Urethrotome 8667 for telescope 4 mm, 0. For slitting urethral strictures under vision...
OES Pro Optical Urethrotome...
... 4.9mm insertion tube, the FCY-15P2 allows ... even through strictured areas. It ... of 125 in air and 83 ... area and simplifying orientation. A ...
Medicine Products: