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JCI online early table of contents: March 9, 2009
Date:3/9/2009

al system in mice and identified two receptor protein tyrosine phosphatases (RPTPs), types S and F (Ptprs and Ptprf, respectively) as being crucially important for both distal ureter maturation and craniofacial morphogenesis. Embryos lacking the genes that code for Ptprs and Ptprf displayed severe urogenital malformations and craniofacial defects such as cleft palate. The data suggest that these two RPTPs normally act redundantly to control key apoptotic events in the distal common nephric duct, allowing correct positioning of the developing ureter against the forming bladder, and subsequent apoptosis in the distal ureter that then allows proper connection of the ureter to the bladder wall. In the absence of these apoptotic events, the ureter fails to contact the bladder, resulting in ureter-bladder malformation. Based on these data, Bouchard et al. present an updated model of how maturation of the ureter-bladder connection takes place.

TITLE: Maturation of ureter-bladder connection in mice is controlled by LAR-family receptor protein tyrosine phosphatases

AUTHOR CONTACT:
Maxime Bouchard
McGill University, Montreal, Quebec, Canada.
Phone: (514) 398-3532; Fax: (514) 398-6769; E-mail: maxime.bouchard@mcgill.ca

View the PDF of this article at: https://www.the-jci.org/article.php?id=37196


CARDIOLOGY: The enzyme CaMKII modulates cardiac inflammation after a heart attack

Inhibition of the enzyme CaMKII (calcium/calmodulin-dependent protein kinase II) has been shown to improve cardiac function after a heart attack, but the CaMKII-dependent signaling pathways involved in the heart's response to stress are not well understood. In their new study, Madhu Singh, Mark Anderson, and colleagues at the University of Iowa, investigate the effects of CaMKII inhibition in the mouse heart af
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Journal of Clinical Investigation
Source:Eurekalert

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