Navigation Links
JCI online early table of contents: March 3, 2008
Date:3/3/2008

EDITOR'S PICK: How the drug isotretinoin zaps acne

The most potent drug available for the treatment of acne is 13-cis retinoic acid (13-cis RA; also known as isotretinoin); however, little is known about the mechanism by which it acts. Insight into the mechanisms by which 13-cis RA combats acne has now been provided by Diane Thiboutot and colleagues, from Pennsylvania State University College of Medicine, Hershey, who analyzed skin biopsies from patients with acne before and after 1 week of treatment with 13-cis RA. The authors suggested these data might lead to the development of new treatments for acne, which are badly needed as the use of 13-cis RA is limited by its severe side effects.

Initial analysis confirmed previous observations made using cultured cells that 13-cis RA induces a form of cell death known as apoptosis in sebaceous glands, the parts of the skin that are affected in individuals with acne. Further studies revealed that the gene responsible for making the protein NGAL was highly upregulated in human sebaceous glands by 13-cis RA. As NGAL was found to mediate apoptosis of human sebaceous glands and to be essential for 13-cis RA to mediate apoptosis of human sebaceous glands, the authors suggested that agents that selectively induce NGAL expression in human sebaceous glands might provide a new approach to treating individuals with acne.

TITLE: Neutrophil gelatinase–associated lipocalin mediates 13-cis retinoic acid-induced apoptosis of human sebaceous gland cells

AUTHOR CONTACT:
Diane M. Thiboutot
Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Phone: (717) 531-7437; Fax: (717) 531-4821; E-mail: dthiboutot@psu.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=33869


EDITOR'S PICK: "Female
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. HIV denialists spread misinformation online -- consequences could be deadly; and more
2. Consequences of online HIV denial; and more
3. Online Epidemic Gives Clues to Bird Flu Spread
4. MedHelp to Add Top Stanford Surgeons and Specialized Forums to Online Health Community
5. Online Celebrity Shoe Charity Auction for Womens Heart Health Opens Bidding
6. Syndicom to Launch Online Community for DePuy Spine
7. Elder Caregiving Site ShirleyBOARD.com Wins WebAward for Outstanding Online Community
8. Peer-Reviewed, Online Database Showcases Local, County and State Pandemic Planning
9. CIGNA Behavioral Health Offers Members Online Provider Profiles
10. Dynamic Energy Systems Goes Online and On-Demand
11. North Shore-LIJ Health System Begins Online Posting of Hospital Infection Rates, Other Performance Information
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... 2015 , ... ProDrop Particles includes over 40 particle backdrops designed for use ... footage that users can shrink and stretch in the Final Cut Pro X timeline. ... color, brightness, scale, speed, range, and flare attributes with intuitive controls found in the ...
(Date:8/28/2015)... ... 29, 2015 , ... Rio Salado College joined nine educational institutions ... part of the EDUCAUSE - Next Generation Learning Challenges 2015 Breakthrough Models Incubator funded ... Breakthrough Models Incubator hosted by EDUCAUSE and NGLC, which is designed to ...
(Date:8/28/2015)... ... August 28, 2015 , ... An article published August 19th by ... has gone through to open a pizzeria in Westchester. Mr. LaRocco was aware from ... several months, but the current process, having already gone on for over a year, ...
(Date:8/28/2015)... ... 28, 2015 , ... The 6th Annual Survivor in the City, Chicago ... yet another accolade to its cadre of widespread support—an official letter of support and ... of the medical community and the University of Illinois at Chicago’s Department of Neurosurgery, ...
(Date:8/28/2015)... ... August 28, 2015 , ... Altima Technologies, Inc., ... network and data center assets and audio-video devices, recently released Visio Stencils for ... Series, HP ProLiant Gen9, EMC VNX Series , Super Micro Computer SuperStorage, Hitachi ...
Breaking Medicine News(10 mins):Health News:FCPX Effects Developer, Pixel Film Studios, Releases ProDrop Particles. 2Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 2Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 3Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 4Health News:Article on Building Approval Process for LA Business Highlights the Need for a Bridge Between Businesses and City Officials, says Fire Protection Group Inc. 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 3Health News:Altima Updates NetZoom™ Visio® Stencil Library for Cisco, HP, and EMC Devices 2Health News:Altima Updates NetZoom™ Visio® Stencil Library for Cisco, HP, and EMC Devices 3
... will able to uncover the fate of the lost colony ... more than 100 people settled on the Roanoke Island ... deeds and historical narratives have gathered around 168 surnames that ... of the English trying to colonize the new world. ...
... with bird flu in Indonesia appear healthy, making it difficult ... for humans, an official said Monday. ,Indonesia, ... has been struggling to control H5N1 outbreaks across its vast ... found that chickens infected by bird flu have not been ...
... majority of Britain's casinos on Monday lost its ... the country's gambling industry. The British Casino ... that Labour's policy to create 17 new casinos, ... existing gaming establishments with "blatant unfairness." ...
... Stress not only makes your present life miserable, it drags ... Alzheimers, say researchers. ,Researchers from Rush University ... are anxious or depressed are 40 times more likely to ... is often a transitional stage between normal aging and dementia, ...
... Japanese scientists have created a vaccine for cholera that can ... of the University of Tokyo and his colleagues inserted the ... into a rice plant, whose genome has recently been mapped. ... were fed to mice they provoked immunity from the diarrhea-causing ...
... might be able to conceive at an age generally thought to ... expected to come up in the next decade or so. ... be developed into a pill or an injection to extend the ... a fertility revolution enabling women to wait longer to have a ...
Cached Medicine News:Health News:DNA Link to a Lost Colony 2Health News:Stress- Harms Now And Later 2Health News:Vaccines On Your Plate 2
(Date:8/29/2015)... y LONDRES, August 29, 2015 ... Anatómica para los sistemas de imagen por ... en Ecografía, tiempos de examen rápidos y un flujo ... mayor confianza diagnóstica en el proceso de detección de ... AEX: PHIA) ha anunciado hoy el lanzamiento europeo de ...
(Date:8/28/2015)... Fla. , Aug. 28, 2015  With the ... reaching deadlier heights, Jacksonville -based ... Philip Hemphill is helping to explain why fentanyl ... is approximately 40 to 50 times more potent than ... recreational users as heroin, the risk of death skyrockets. ...
(Date:8/28/2015)... Aug. 28, 2015  Delays in the launch ... slow down the decision-making process, resulting in missed ... critical for biopharmaceutical companies to develop a tactical ... for quicker and more meaningful insights. ... LLC, nearly three-quarters of benchmarked study participants use ...
Breaking Medicine Technology:Philips presenta HeartModel A.I en el Congreso ESC 2015 2Philips presenta HeartModel A.I en el Congreso ESC 2015 3Philips presenta HeartModel A.I en el Congreso ESC 2015 4Philips presenta HeartModel A.I en el Congreso ESC 2015 5Lakeview Health's Dr. Philip Hemphill Explains Why Heroin Addicts Are Now Dying of Fentanyl Overdoses 2Expediting the Pharmaceutical Market Research Process for Faster Insights 2
... -- CEL-SCI,CORPORATION announces that CEL-1000 increased the ... combination with MAS-1, a,water-in-oil adjuvant delivery system. ... by Dr. Daniel Zimmerman, Senior Vice,President of ... Society of Microbiologists 107th annual general meeting ...
... Work Status and,Productivity, WASHINGTON, May 23, 2007 /PRNewswire-FirstCall/ ... (DDW), from,long-term extensions of the ACT trials (Active ... moderately to severely active,ulcerative colitis (UC) who had ... the trials maintained,improvement in their clinical symptoms for ...
Cached Medicine Technology:CEL-SCI'S CEL-1000 Shown to Significantly Enhance Immune Response,Against Avian Flu Antigen in Animals 2Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 2Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 3Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 4Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 5Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 6Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 7Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 8Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 9
Welch Allyn quality in a convenient pocket size. The PocketScope fits into your pocket! Easy to use, lightweight, and perfect for general and specialist use. Take your PocketScope with you everywhere...
... enables a fast, precise patternless edge for ... the TOPCON ALE-X1. The latest advance in ... improved features and functions. High-speed processing, a ... beveled edges, precise three-dimensional frame tracing via ...
... mapping software system enhances clinical evaluations with ... corneal maps. The system offers an enlarged ... refractive and keratometric data, and peripheral keratometric ... subclinical keratoconus as well as pre and ...
... Ergonomic, computer-integrated, flexibility, combined with the ... contemporary styling, make the new Topcon ... highly competitive 21st Century practice environments: ... lane fits comfortably in an 8' ...
Medicine Products: