Navigation Links
JCI online early table of contents: March 14, 2011
Date:3/14/2011

polices cancer growth by regulating c-Jun

Cancer growth occurs due to uncontrolled cell division, which can result from the loss of proteins that repress cell cycle progression (tumor suppressors) or by increases in the amount or activity of proteins that promote cell cycle progression (oncogenes). In many cancers, loss of the tumor suppressor p53 activity is an important contributing factor to the uncontrolled cell growth. Thus, identifying the factors that contribute to controlling p53 levels has been of interest to cancer researchers. In cultured cancer cells, the protein Cop1 has been shown to target p53 for degradation, and thus there has been interest in developing inhibitors of Cop1 as cancer therapeutics.

In this paper, Jean-Christophe Marine at the Laboratory For Molecular Cancer Biology Leuven, Belgium developed a series of mouse models that demonstrate that in contrast to predictions, loss of Cop1 does not affect p53 levels or activity. Rather, Cop1 targets for degradation a protein that promotes cell cycle progression called c-Jun, and loss of Cop1 resulted in spontaneous cancer formation in the mice. The researchers believe that these findings suggest that Cop1 itself acts as a tumor suppressor, and that c-Jun, rather than p53, is its primary target in this context. In the accompanying commentary, Wenyi Wei of Beth Israel Deaconess Medical Center and William Kaelin, from Dana Farber Cancer Institute, in Boston, Massachusetts, stress that these findings suggest that inhibitors of Cop1 are unlikely to be effective cancer therapeutics, and may even enhance tumor growth.

TITLE: Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice

AUTHOR CONTACT:
Jean-Christophe Marine
VIB-KULeuven, Leuven, BEL
Phone: 003216330368; Fax: ; E-mail: JeanChristophe.Marine@cme.vib-kuleuven.be
View this article at:

Contact: Kathryn Claiborn
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9

Related medicine news :

1. JCI online early table of contents: March 7, 2011
2. Study Finds Drop in Online Sales of Cigarettes
3. JCI online early table of contents: Feb. 14, 2011
4. New online tool predicts probability of death from stroke
5. JCI online early table of contents: Feb. 7, 2011
6. Online registration opens for 14th World Conference on Lung Cancer in Amsterdam
7. Online, Mail Reminders Improve Colon Cancer Screening Rates
8. JCI online early table of contents: Dec. 6, 2010
9. JCI online early table of contents: Dec. 1, 2010
10. Elsevier launches innovative online radiology board review product
11. Online map of maternal health to inform world leaders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2015)... On May 13, Nithyananda Yoga Foundation ... yogic power learned through meditation and initiation at Special ... India. , Yogamaatha, a nine-year-old girl from North Carolina, ... professionals attending the 2015 Business Advocacy Summit at Capitol ... , In a demonstration that lasted three hours, ...
(Date:5/23/2015)... NY (PRWEB) May 23, 2015 On ... that, “the company has been the target of ... a part of the company’s ongoing Information Technology (IT) ... health insurers.” , The most notable attack on ... when Anthem Inc., the nation’s second largest health insurer, ...
(Date:5/23/2015)... May 23, 2015 A live auction will ... from hospitals, surgery centers and other medical facilities around the ... including endoscopy, lab, radiology, surgery, anesthesia, exam and much more. ... 27 and Thursday, May 28 starting at 9:00am CDT each ... 1400 N. 25th Avenue, Melrose Park, IL 60160. Anyone ...
(Date:5/23/2015)... MD (PRWEB) May 23, 2015 Injury lawyer ... that has been passed by the Maryland legislature but which ... “The Maryland General Assembly passed HB 449 with ... Governor has not signed it into law. This bill ensures ... Evidence is growing that demonstrates the danger of fracking to ...
(Date:5/22/2015)... Francisco, CA (PRWEB) May 22, 2015 ... hosting two exciting events in June. They will hold ... Professional Doctorate and a two-day class on Classical Chinese ... p.m. June 3, Dr. Steve Given, the Dean of ... will discuss the new First Professional Doctorate program. ACTCM ...
Breaking Medicine News(10 mins):Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 2Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 3Health News:One Headline Making Cyber Attack Sparks Discovery of Another 2Health News:One Headline Making Cyber Attack Sparks Discovery of Another 3Health News:One Headline Making Cyber Attack Sparks Discovery of Another 4Health News:Over 5,200 Lots of Medical Equipment Will Be Sold by Live Auction 2Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 2Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 3Health News:ACTCM Announces Upcoming June Events 2
... International Union files anti-SLAPP motion against,the California ... stunt, OAKLAND, Calif., April 21 ... an anti-Strategic Lawsuit,to Prevent Public Participation motion ... the union from further efforts to silence,critics ...
... According to researchers at The University of Texas M. ... cancer screening and early detection, has shown to significantly ... breast cancer in women over the age of 80, ... screenings. , The study, published online today ...
... Mich., April 21 /PRNewswire-FirstCall/ .- Perrigo Company,(Nasdaq: ... filed an Abbreviated New,Drug Application (ANDA) for over-the-counter ... a generic version of Monistat(R) 1,Combination Pack. The ... file an ANDA,with a Paragraph IV certification against ...
... (Jack) F. Smith Jr. to Retire: Kenneth I. Chenault Appointed to Board ... ... Company (NYSE: PG ) today announced that John (Jack) F. Smith (70),will ... To view the Multimedia News Release, go to:, http://www.prnewswire.com/mnr/pg/32757/ ...
... using a tray saves water and energy; reduces food waste, ... on,300 college campuses served by Sodexo will line up to ... plastic tray. The move was introduced by Sodexo,as part of ... trayless saves thousands of gallons of water each day,and reduces ...
... MDS Board, TORONTO, April 21 /PRNewswire-FirstCall/ - MDS ... and services to the global life,sciences markets, today announced ... William Dempsey, former Executive Vice-President,of Abbott Laboratories, have been ... both Greg and Bill and look forward to benefiting ...
Cached Medicine News:Health News:SEIU Seeks Damages for CNA's Effort to Silence Workers, Suppress Criticism of Anti-Union Tactics 2Health News:SEIU Seeks Damages for CNA's Effort to Silence Workers, Suppress Criticism of Anti-Union Tactics 3Health News:SEIU Seeks Damages for CNA's Effort to Silence Workers, Suppress Criticism of Anti-Union Tactics 4Health News:Mammography may be beneficial to all women, regardless of age 2Health News:Mammography may be beneficial to all women, regardless of age 3Health News:Perrigo Confirms Patent Challenge of Monistat(R) 1 Combination Pack 2Health News:Perrigo Confirms Patent Challenge of Monistat(R) 1 Combination Pack 3Health News:Procter & Gamble Announces Board Changes 2Health News:Sodexo Challenges Diners on College Campuses to Go Trayless and Go Green 2Health News:MDS Appoints Two New Directors 2Health News:MDS Appoints Two New Directors 3
(Date:5/21/2015)... , May 21, 2015 ... has announced the addition of the ... their offering. ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,The ... and size the world market for Arthroscopy ... identifies trends impacting the market for these ...
(Date:5/21/2015)... 2015  Cardica, Inc. (Nasdaq: CRDC ) today announced ... , the company,s vice president of operations, was granted an ... at a per share exercise price of $0.43, the closing ... granted pursuant to Cardica, Inc.,s Inducement Plan, which was approved ... Rule 5653(c)(4) of the Nasdaq Global Market for equity grants ...
(Date:5/21/2015)... WASHINGTON , May 21, 2015 ... following statement regarding the Medicare Part D offsets ... Century Cures initiative: "If the 21st Century ... billions from America,s premier health program – Medicare ... it may yield down the road. ...
Breaking Medicine Technology:Analysing Arthroscopy Devices Markets Worldwide 2014-2020 2Analysing Arthroscopy Devices Markets Worldwide 2014-2020 3Cardica Announces New Employment Inducement Grant 2
... The visco-elastic ENDOGEL is a ... sodium hyaluronate. ENDOGEL is supplied in ... with a Luer-Lock fitting, delivering 0,85 ... linear polysaccharide composed of repetitive chains ...
... is designed to provide excellent protection and ... advantage of being closer to an adhesive ... This allows CoEase to maintain viscosity at ... of both worlds for superb performance during ...
... sterile, nonpyrogenic, viscoelastic preparation of a ... fraction of sodium hyaluronate., ,Healon contains ... in physiological sodium chloride phosphate buffer ... polymer is made up of repeating ...
... device is a highly retentive, dispersive ... molecular weight, low pseudoplasticity and low ... maintenance and excellent tissue protection. It ... size (catalog number 8065183905) or as ...
Medicine Products: