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JCI online early table of contents: March 14, 2011
Date:3/14/2011

ashington University, School of Medicine, St. Louis, MO, USA
Phone: 314-362-0367; Fax: 314-362-4096; E-mail: mcolonna@pathology.wustl.edu

View this article at: http://www.jci.org/articles/view/44005?key=c5f31cc0776eeafb49e8

IMMUNOLOGY Understanding how to use the immune system to fight cancer

Bone marrow transplants have become a standard of care in treating patients suffering from leukemia, but despite high success rates, some patients eventually relapse. In recent years, relapsing patients have been treated with infusions of white blood cells from the individual who originally donated the bone marrow, a process called donor leukocyte infusion (DLI). The goal of this treatment is to allow the patient to develop antibodies that recognize and kill tumor cells, but the mechanism behind this process is not completely understood.

In new research, Yu Lin, Catherine Wu and colleagues, at the Dana-Farber Cancer Institute in Boston, Massachusetts, investigated the immune stimulatory properties of plasma from DLI-treated patients. The plasma stimulated the activity of cultured immune cells in part by activating innate immune responses, suggesting that it contained nucleic acids, which are known to have this property. Indeed, the group determined that nucleic acids were required to induce an effective anti-tumor response. The researchers hope that their findings will be useful in the design of anti-tumor vaccines.

TITLE: Effective posttransplant antitumor immunity is associated with TLR-stimulating nucleic acidimmunoglobulin complexes in humans

AUTHOR CONTACT:
Yun Lin
Dana Farber Cancer Institute, Boston, MA, USA
Phone: 6176888855; Fax: ; E-mail: camboston123@yahoo.com

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Contact: Kathryn Claiborn
press_releases@the-jci.org
Journal of Clinical Investigation
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