Navigation Links
JCI online early table of contents: March 14, 2011
Date:3/14/2011

/p>

TITLE: Lipid Profiling Identifies a Triacylglycerol Signature of Insulin Resistance and Improves Diabetes Prediction in Humans

AUTHOR CONTACT:
Robert Gerszten
Massachusetts General Hospital, Charlestown, MA, USA
Phone: 617-724-8322; Fax: 617-726-1544; E-mail: RGERSZTEN@PARTNERS.ORG

View this article at: http://www.jci.org/articles/view/44442?key=2db0a8efbc938e79f05b


IMMUNOLOGY Virus sensors help prevent type 1 diabetes

Type 1 diabetes (T1D) is a failure to maintain normal blood sugar levels due to death of the insulin-producing pancreatic β cells, most often resulting from autoimmune T cell-mediated attack. Multiple genetic variants have been found to be associated with the disease, and recent studies have also suggested that viral infection may contribute to the development of T1D. However, it is unclear whether viral infection of β cells results in direct damage, or whether the immune response to the virus initiates a T cell-mediated β cell killing.

In this paper, Marco Colonna and colleagues, at Washington University School of Medicine in St. Louis, Missouri, investigated the role of the immune response in a mouse model of virally-induced T1D. They found that two genes involved in helping cells recognize invading viruses, toll like receptor 3 (Tlr3) and melanoma differentiation-associated gene 5 (Mda5), were important in protecting infected mice from developing T1D. In mice lacking those genes, the virus was better able to infect and kill β cells. The researchers believe that these findings suggest that the immune system can both promote and prevent T1D, depending on the underlying pathology in the patient.

TITLE: RNA sensorinduced type I IFN prevents diabetes caused by a β celltropic virus in mice

AUTHOR CONTACT:
Marco Colonna
W
'/>"/>

Contact: Kathryn Claiborn
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9

Related medicine news :

1. JCI online early table of contents: March 7, 2011
2. Study Finds Drop in Online Sales of Cigarettes
3. JCI online early table of contents: Feb. 14, 2011
4. New online tool predicts probability of death from stroke
5. JCI online early table of contents: Feb. 7, 2011
6. Online registration opens for 14th World Conference on Lung Cancer in Amsterdam
7. Online, Mail Reminders Improve Colon Cancer Screening Rates
8. JCI online early table of contents: Dec. 6, 2010
9. JCI online early table of contents: Dec. 1, 2010
10. Elsevier launches innovative online radiology board review product
11. Online map of maternal health to inform world leaders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... Manchester scientists are working out how to safely increase ... potentially offering improved local control and survival. , Standard ... a combination of radiotherapy and chemotherapy. Traditionally this is ... may not always be enough to stop tumour growth. ... the cancerous tissue varies between patients and depends on ...
(Date:8/28/2014)... York (PRWEB) August 28, 2014 Vaccine ... perceived with great interest among other healthcare industry sectors ... the high demand in vaccine with respect to evolving ... in demand due to an improved understanding for a ... the United States. It has led to new opportunities ...
(Date:8/28/2014)... 2014 AmeriPride Services, a leading textile ... the launch of its new Customer Portal, an online ... and more convenient for customers. The industry-leading digital tool ... communicate with the company. , Features of the new ... Access, download and pay bills online , ...
(Date:8/28/2014)... After more than two years of ... excited to announce the opening of Houston’s Mirror Mirror ... city, Mirror Mirror Beauty Boutique offers premium aesthetic services ... corner of Richmond and Drexel near Highland Village, Mirror ... cutting-edge technology in a private, easy to access location. ...
(Date:8/28/2014)... Hastings and Hastings is a Phoenix personal injury ... services and other legal services in Arizona for over ... it has saved a client more than $23,000 related ... half of a million dollars. This is concrete proof ... that result in real savings for clients. Measured in ...
Breaking Medicine News(10 mins):Health News:Research demonstrates potential method to better control lung cancer using radiotherapy 2Health News:U.S. Vaccine Market: Opportunities and Threats by Transparency Market Research 2Health News:U.S. Vaccine Market: Opportunities and Threats by Transparency Market Research 3Health News:AmeriPride Services Launches New Customer Portal 2Health News:AmeriPride Services Launches New Customer Portal 3Health News:Mirror Mirror Beauty Boutique to Welcome Its First Patients 2Health News:Hastings and Hastings Is Pleased To Report Having Saved A Client $23,400 On Settlement Of $540,000 2Health News:Hastings and Hastings Is Pleased To Report Having Saved A Client $23,400 On Settlement Of $540,000 3
... in Memory: Why Some Birthdays Are Harder to Remember ... and Shigehiro Oishi People may have a better ... Volunteers recalling their friends, birthdays tended to remember birthdays ... were farther away from their own birthday. In a ...
... By Serena Gordon HealthDay Reporter , TUESDAY, Nov. ... reports being adequately trained to deal with asthma symptoms in kids, ... two coaches knew more than one asthma symptom, according to the ... meeting of the American College of Chest Physicians, in Vancouver, Canada. ...
... Wash.November 2, 2010The Allen Institute for Brain Science ( ... which includes new data and tools for exploring genes ... expanding and enhancing the Allen Human Brain Atlas, the ... Ivy Glioblastoma Atlas Project and the NIMH Transcriptional Atlas ...
... Randy Dotinga HealthDay Reporter , TUESDAY, Nov. 2 ... Science may be onto you. Researchers report that they,ve ... differently when they,re trying to manipulate others into believing something ... The findings hint at how complicated bluffing is compared ...
... may be responsible for up to one-third of strokes ... all cases of blood clots in large veins, and ... trials have been conducted involving people with APS, and ... To stimulate an international discussion on this topic, the ...
... CA (November 1, 2010)Breast cancer, one of the most ... each year and causes about 40,000 deaths annually. The ... through lymphovascular invasion (LVI)a process in which cancer cells ... translate into a poor prognosis for patients. Some ...
Cached Medicine News:Health News:New research from Psychological Science 2Health News:New research from Psychological Science 3Health News:New research from Psychological Science 4Health News:Many Coaches Unprepared for Student-Athletes' Asthma 2Health News:Many Coaches Unprepared for Student-Athletes' Asthma 3Health News:20th public data release by Allen Institute for Brain Science 2Health News:20th public data release by Allen Institute for Brain Science 3Health News:Study Unmasks the Biology of Bluffing 2Health News:International summit held to stimulate collaborative clinical research on antiphospholipid syndrome 2Health News:Fox Chase researchers identify risk factors for the spread of breast cancer to lymph nodes 2
(Date:8/28/2014)... WOONSOCKET, R.I. , Aug. 28, 2014  In ... of developing health complications from the flu, pneumonia, ... MinuteClinic ® have declared September to be ... as they age, it is important that adults ... date on their vaccinations. CVS pharmacists and MinuteClinic ...
(Date:8/28/2014)... ROCK, Colo. , Aug. 28, 2014   ... diagnostic company focused on obtaining FDA clearance for and ... rapid blood test for aiding in identifying children, adolescent, ... are at low risk for appendicitis, today announced it ... & Renshaw 16 th Annual Global Investment Conference ...
(Date:8/28/2014)... 28, 2014  Stryker Orthopaedics, the Official Joint Replacement Products ... message of joint health to golf fans at the next ... Deutsche Bank Championship. The company,s fan destination – "The Stryker ... on 9" at the TPC Boston in Norton, ...    At the Deutsche Bank Championship, Stryker will ...
Breaking Medicine Technology:September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 2September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 3September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 4Venaxis to Present at September Investor Conferences 2Venaxis to Present at September Investor Conferences 3Stryker, Official Joint Replacement Products Of The PGA TOUR, Heads To Boston For The Deutsche Bank Championship 2Stryker, Official Joint Replacement Products Of The PGA TOUR, Heads To Boston For The Deutsche Bank Championship 3Stryker, Official Joint Replacement Products Of The PGA TOUR, Heads To Boston For The Deutsche Bank Championship 4Stryker, Official Joint Replacement Products Of The PGA TOUR, Heads To Boston For The Deutsche Bank Championship 5
... Aug. 3, 2011 Reportlinker.com ... research report is available in ... Canada Orthopedic Devices Market Outlook ... Spinal Surgery, Orthobiologics, Trauma Fixation ...
... 2011 Grifols, a global healthcare company and ... the structure of its new North American Commercial ... U.S. commercial group will be organized by product ... North America.  The Canadian organization, a major presence ...
Cached Medicine Technology:Canada Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 2Canada Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 3Canada Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 4Canada Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 5Canada Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 6Canada Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 7Canada Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 8Canada Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 9Canada Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 10Canada Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 11Canada Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 12Canada Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 13Canada Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 14Canada Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 15Canada Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 16Canada Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 17Canada Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 18Canada Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 19Canada Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 20Grifols Announces New North American Commercial Operations Organization 2Grifols Announces New North American Commercial Operations Organization 3
... mechanism for speed, stability and durability. ... display modes, multiple units of measure, ... auto print, and GLP/GMP/ISO output including ... clock. Built-in, motor-driven internal calibration ...
TOPLOAD 3200/0.01G, BL3200H. Touch-key external calibration only. Requires calibration weights (either 2000g or 3000g). 120/240V A/C adapter, Lock-down Ring, In-use Protective Cover....
... Portable - Battery Powered (6 size AA ... conversion (g, ct, oz, ozt, GN, dwt, ... Counting and Percent Measure functions, Auto Print. ... Optional AC adapter may be ordered for ...
... BX620S. Digital stability control, analog display ... counting and percent measure functions, auto ... and time data from built-in clock. ... (selectable from 200g to 600g). Built-in ...
Medicine Products: