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JCI online early table of contents: March 14, 2011
Date:3/14/2011

ated with increasing disease severity. They also determined that in a mouse model of HD, development of an auditory deficit preceded the development of motor symptoms, and HD mice had reduced levels of CKB in their cochlea. Remarkably, adding creatine to the diets of HD mice elevated the level of CKB and reduced the extent of hearing loss. The team hopes that their findings indicate that a promising therapy to treat the hearing loss in HD patients might be right around the corner.

TITLE: Dysregulated brain-type creatine kinase is associated with hearing impairment in mice with Huntington disease

AUTHOR CONTACT:
Yijuang Chern
Institute of Biomedical Sciences, Academia Sinica, Taipei, UNK, TWN
Phone: 886-2-26523913; Fax: 886-2-27829143; E-mail: bmychern@ibms.sinica.edu.tw

View this article at: http://www.jci.org/articles/view/43220?key=27d256ef5f24287b3cca


METABOLISM A new method to predict diabetes risk

As the obesity epidemic has grown, so has the incidence of diabetes, a chronic condition that currently affects almost 8% of US adults. Recent work has suggested that obese individuals and those with high amounts of lipid (fat) in their blood are more susceptible to developing diabetes, but it is still difficult to determine which individuals are most at risk. In new research, Robert E. Gerszten and colleagues, at Massachusetts General Hospital in Boston, carefully analyzed the lipid content of blood from a number of patients who had developed diabetes, and compared them to individuals who remained healthy. They found that modifications of a specific kind of lipid called triacylglycerols were reliable markers of relative diabetes risk. The scientists hope that this work might allow physicians to identify the patients most in need of interventional measures for diabetes prevention.<
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Contact: Kathryn Claiborn
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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