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JCI online early table of contents: March 14, 2011
Date:3/14/2011

t the MD Anderson Cancer Center in Houston, Texas, investigated the extracellular cues that promote metastasis in a mouse model of lung cancer. They found that activation of the Notch intracellular signaling pathway decreased the expression of miR-200, and thus increased EMT and made tumor cells more prone to metastasize. The scientists are hopeful that these findings suggest that therapies that inhibit the Notch pathway might prevent metastasis in lung cancer patients.

TITLE: The Notch Ligand Jagged2 Promotes Lung Adenocarcinoma Metastasis Through a miR-200-dependent Pathway in Mice

AUTHOR CONTACT:
Jonathan Kurie
M. D. Anderson Cancer Center, Houston, TX, USA
Phone: 713-792-6363; Fax: 713-796-8655; E-mail: jkurie@mdanderson.org

View this article at: http://www.jci.org/articles/view/42579?key=94785b90de89c56ad3a4


NEUROBIOLOGY Hope for hearing impairment in Huntington Disease

Huntington Disease (HD) is an incurable neurodegenerative genetic disorder associated with the development of uncontrollable movements. Recent studies of HD patients have also shown that many of them develop hearing deficits in the late stages of the disease, but the mechanism that explains this defect is not understood. However, there is increasing evidence that some of the symptoms of HD are related to defects in cellular energy levels. The enzyme brain-type creatine kinase (CKB) helps control the supply of energy to certain kinds of cells, including the hair cells of the inner ear (cochlea), and CKB is known to be dysregulated in the brains of HD patients.

In this paper, Yijuang Chern of the Institute of Biomedical Sciences, Academia Sinica, and Chih-Hung Wang, of Tri-Service General Hospital in Taipei, Taiwan and colleagues assessed the hearing of HD patients, and confirmed that a hearing deficit was associ
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Contact: Kathryn Claiborn
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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