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JCI online early table of contents: March 14, 2011
Date:3/14/2011

EDITOR'S PICK An inside look at how the elite control HIV

In the years since the AIDS epidemic began, it has become clear that there is substantial variation in the way that individuals respond to HIV infection. Although most progress quickly from initial infection to immunodeficiency, a small subset survive for long periods without developing symptoms. These patients, dubbed elite controllers, display undetectable levels of viral replication, but the mechanism that explains how their immune systems effectively control the virus is not understood.

In this paper, Mathias Lichterfeld and colleagues, at Massachusetts General Hospital in Boston, describe that the T cells from elite controllers are relatively resistant to infection with HIV because they upregulate a protein called p21, which in turn inhibits an enzyme required for the virus to replicate. In addition, blocking p21 increased the expression of viral genes. The researchers hope that this finding may inform the design and development of treatment strategies for patients who are more susceptible to the virus' tragic effects

TITLE:
CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21

AUTHOR CONTACT:
Mathias Lichterfeld
Massachusetts General Hospital, Boston, MA, USA
Phone: 617-726-3167; Fax: ; E-mail: mlichterfeld@partners.org

View this article at: http://www.jci.org/articles/view/44539?key=2a386ca6b649875591bc


EDITOR'S PICK New mouse model explains common pediatric brain tumor

Pilocytic astrocytoma (PA) is the most common pediatric brain tumor, and there are few medical therapies available to those patients for whom surgery is not curative. However, it has been difficult to design targeted PA therapies because the cellular mechanisms that lead to t
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Contact: Kathryn Claiborn
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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