JCI online early table of contents: Marc...(it nutrients and enable it to disseminat...),Health

Date:3/13/2008

it nutrients and enable it to disseminate to new sites. This process is known as neovascularization, and recent evidence has suggested that mobilization of cells known as endothelial progenitor cells (EPCs) from the bone marrow might be crucial for neovascularization in several cases. Now, data generated by a team of researchers from Chittaranjan National Cancer Institute, India, and the Mayo Clinic, Rochester, has determined that a chemical known to be involved in transmitting signals from nerve cells (dopamine; DA) regulates EPC mobilization from the bone marrow in mice.

In the study decreased levels of DA in the bone marrow were associated with increased mobilization of EPCs in mice bearing tumors known as sarcomas and administration of DA inhibited this mobilization. The ability of DA to inhibit EPC mobilization from the bone marrow was mediated via the DA D2 receptor expressed by the EPCs. These data led the authors to suggest that DA as well as DA D2 receptor agonists, which are widely used in the clinic for the treatment of several conditions including Parkinson disease, might provide new approaches to the treatment of cancer.

TITLE: Dopamine regulates endothelial progenitor cell mobilization from mouse bone marrow in tumor vascularization

AUTHOR CONTACT:
Partha Sarathi Dasgupta
Chittaranjan National Cancer Institute, Kolkata, India.
Phone: 91-33-24765101 ext. 324; E-mail: partha42002@yahoo.com.

MEDIA CONTACT:
Amy Reyes
Communications Consultant
Mayo Clinic Department of Public Affairs, Mayo Clinic, Rochester, Minnesota, USA.
Phone: (507) 284-2590; E-mail: reyes.amelyn@mayo.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=33125</p>

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Contact: Karen Honey press_releases@the-jci.org 215-573-1850 Journal of Clinical Investigation Source:Eurekalert

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