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JCI online early table of contents: June 13, 2011
Date:6/13/2011

ton, has now identified VentX as a gene regulatory protein that is key to the generation of human macrophages from monocytes. Importantly, the team also found that VentX is pivotal to the proinflammatory function of human macrophages. As expression of VentX was found to correlate with expression of proinflammatory mediators in immune cells isolated from the blood of patients with autoimmune diseases, the authors suggest that dysregulation of VentX may play a role in the development of autoimmune diseases.

TITLE: The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation

AUTHOR CONTACT:
Zhenglun Zhu
Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Phone: 617.732.5467; Fax: 617.730.5807; E-mail: zzhu@partners.org.

View this article at: http://www.jci.org/articles/view/45556?key=83149a785ad368615724


CARDIOVASCULAR DISEASE: Fat accumulation in the heart impairs survival

The leading cause of death in the United States is a condition known as coronary heart disease, one complication of which is heart attack. Coronary heart disease is the term given to narrowing of the small blood vessels that supply blood and oxygen to the heart. As a result of the condition, there is inadequate oxygenation of the heart muscle and this promotes the accumulation of fats known as triglycerides in heart muscle cells. The accumulation of triglycerides in heart muscle cells is associated with impaired heart function, but whether the former causes the latter has not been determined. Now, a team of researchers, led by Jan Born, at Sahlgrenska University Hospital, Sweden, has found that the former does indeed cause the latter.

The team found that the protein VLDLR is required for the accumulation of tri
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Journal of Clinical Investigation
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