Navigation Links
JCI online early table of contents: June 12, 2008
Date:6/12/2008

link inflammation to obesity-related metabolic diseases

Individuals who are obese are predisposed to a variety of metabolic conditions, including type 2 diabetes. A characteristic of the fat tissue (adipose tissue) of individuals who are obese is that it is inflammed, and understanding the relationship between such inflammation and the onset of the metabolic conditions is of importance in combating what has become a large public health problem. In a new mouse study, Gkhan Hotamisligil and colleagues, at the Harvard School of Public Health, Boston, found that interactions between adipocytes (fat cells) and inflammatory cells called macrophages seem to underlie the inflammation-related metabolic deterioration associated with obesity.

In the study, when adipocytes isolated from mice lacking proteins known as FABPs, which are molecules that govern metabolic and inflammatory responses, were cultured with normal macrophages, the macrophages expressed reduced levels of inflammatory molecules. Likewise, when macrophages isolated from mice lacking FABPs were cultured with normal adipocyes, the adipocytes responded more to insulin and took up more glucose. Similar results, indicating that FABPs from both adipocytes and macrophages contribute to the inflammatory basis for metabolic deterioration, were obtained in vivo. The authors therefore suggest that this FABP-related pathway may be a novel target for metabolism-related disorders.

TITLE: Adipocyte/macrophage fatty acidbinding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice

AUTHOR CONTACT:
Gkhan S. Hotamisligil
Harvard School of Public Health, Boston, Massachusetts, USA.
Phone: (617) 432-1950; Fax: (617) 432-1941; E-mail: ghotamis@hsph.harvard.edu.

View the PDF of this article at: https://www.the-jci.org/
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. A self-help program delivered online can improve insomnia in adults
2. The HealthCentral Network Acquires MedTrackAlert, Extending its Ability to Reach Highly Engaged Online Health Consumers
3. JCI online early table of contents: June 5, 2008
4. Death on the Net? Over 60% of Medicines Sold by Online Pharmacies are Fake
5. Online Directory Lists Anatomical Donation Programs in U.S. Offering Free Cremations
6. Virginia Motor Vehicle Crash Outcomes ONLINE at www.vacodes.org
7. MedTrust Online Collaborates With Oracle and Dell to Provide Oncologists With the Next Generation Tool for Personalized Care Delivery
8. The National Association For Continence and The HealthCentral Network Form Alliance to Develop New Online Resources for Patients Coping with Incontinence
9. Video/Online Games for Health: 12 Research Teams From Across U.S. To Receive Major Grants
10. Real Time, Face-to-Face Doctor Visits Now Available Online
11. MDNG Offers Free Online Discussion With Maverick Physician Jay Parkinson, M.D.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... York, NY (PRWEB) October 20, 2014 ... be introduced in the U.S., has a lot to celebrate ... when our country recognizes the achievements and contributions of Americans ... the anniversary for Punzoné, and today it shares its favorite ... take a trip to Italy - even if it is ...
(Date:10/20/2014)... 20, 2014 Do you ever feel ... comes a wonderful app Metassessor for teachers, specialists and ... helped its client “Intervention Development LLC” to launch ... is designed for iOS 4.3 or later and is ... is optimized for iPhone 5. It is now available ...
(Date:10/19/2014)... The leading review website, Top10BestSEOHosting.com, has recently announced ... the best Dedicated Server Hosting suppliers. Their websites ... buy high quality hosting and save money at ... Top10BestSEOHosting.com says, “We believe that iPage and GreenGeeks ... lot of the global clients enjoy using their ...
(Date:10/19/2014)... UNITED NATIONS, New York (PRWEB) October 19, 2014 ... the United Nations Population Fund, welcomes news of a ... release of the more than 200 girls who were ... Girls. "These girls have languished in captivity long enough, ... their families, schools and communities," stated Dr. Osotimehin. , ...
(Date:10/19/2014)... October 20, 2014 Having been working in ... good knowledge of customer needs. According to James, one of ... with dazzling sequins, or with high-low skirts that add beauty ... huge demand. Recently, LunaDress has unveiled its new selection of ... fact, the company’s brand new items are available in over ...
Breaking Medicine News(10 mins):Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 2Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 3Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 4Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 2Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 3Health News:Top10BestSEOHosting.com Considers iPage And GreenGeeks As The Best Dedicated Server Hosting Suppliers 2Health News:2014 Long Prom Dresses From LunaDress Now Available In Over 20 Popular Designs 2
... "Occlusions in the retinal vein could not only make you loose ... veins is so painful that the eye may have to be ... new instrument that uses a plasma to shoot tiny bullets ... vessels that supply blood to the retina drain into a single ...
... market is currently dominated by the Mumbai based ... company, is planning to enter the anti-AIDS drugs ... and west Asia, S D Kaul, the company ... Aabacavir and Indinavir products in the Indian market ...
... that can have Complication as its other name. Among the ... be the foot ulcer, as damage can be severe enough ... ulcer, a boon in disguise would be a new device ... //Such an electrical stimulation would help in the healing of ...
... procedure widely used on knees can also repair damaged ... best known for repairing knee injuries, but it is ... it is a minimally invasive surgical technique it is ... relieve different ankle problems, including ligament damage, bone chips ...
... basis. One of these latest laser techniques is helpful in ... This degenerative condition cause blood vessels to grow underneath the ... ,Eye specialists have come up with a new therapy ... of damaging the retinal tissue. ,This is a two-step ...
... active ingredient is Acetaminophen is found effective in the ... temperature in people who have had a stroke, according ... ,Rise in the body temperature during the first few ... fever, has been linked to poorer outcomes including an ...
Cached Medicine News:Health News:Blocked viens block eye sight 2Health News:Arthroscopy for Ankles 2
(Date:10/19/2014)... Shire plc (LSE: SHP, NASDAQ: SHPG ) announces ... notified the Board of Directors of his decision to step down ... CFO of Severn Trent plc.  James will leave Shire at the ... for a new CFO immediately. Flemming Ornskov, Shire,s Chief ... a high-quality finance team at Shire. We are very grateful to ...
(Date:10/18/2014)... , Oct. 18, 2014  In a ... Rights Campaign (HRC), the nation,s largest lesbian, gay, ... endorsed the use of Truvada for Pre-Exposure Prophylaxis ... tool used to prevent the spread of a ... the only brand name anti-HIV drug combination currently ...
(Date:10/17/2014)... THOUSAND OAKS, Calif. , Oct. 17, 2014 /PRNewswire/ ... appointment of R. Sanders Williams , M.D., president ... L. Mahley Distinguished Professor.  "We are ... the Amgen Board," said Robert A. Bradway , ... deep and distinguished experience in academic medicine and his ...
Breaking Medicine Technology:Interim Chief Financial Officer James Bowling to Step Down 2Interim Chief Financial Officer James Bowling to Step Down 3Interim Chief Financial Officer James Bowling to Step Down 4HRC Endorses PrEP, Calls for Bold Action to Expand Access to Anti-HIV Drug 2HRC Endorses PrEP, Calls for Bold Action to Expand Access to Anti-HIV Drug 3Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 2Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 3
...  Fuse Science Inc. (OTCQB: DROP), ( www.fusescience.com ) announced ... in South Florida through a distribution partnership with GAT ... has begun, led by GAT Trading President, Gustavo Tobon, ... regarding the efficacy of the EnerJel™ product. Fuse Science ...
... MOUNTAIN VIEW, Calif., May 15, 2012  Connecting healthcare points ... is a progressing focus in the healthcare industry.  Rapid ... of electronic health records (EHRs), smart phones, and other ... flattening of the overall markets as they took a ...
Cached Medicine Technology:EnerJel™ Adds 200 Independent Pharmacies To Distribution Base 2Frost & Sullivan Research Preview: Top 20 Telehealth Markets 2Frost & Sullivan Research Preview: Top 20 Telehealth Markets 3Frost & Sullivan Research Preview: Top 20 Telehealth Markets 4
Inquire...
... Calf Implants are available ... sizes. They are available non-sterile ... and sold individually. Depending on ... may use one or two ...
... the IQmark family elevates your ECG and Spirometry ... cost-savings and efficient patient care. The IQmark Diagnostic ... office, clinics and medical centers as well as ... in conjunction with the IQmark Digital ECG PDA ...
... data-gathering extension of the IQmark Diagnostic Workstation, ... Windows-based PC to deliver unmatched speed, accuracy ... Now you can download and seamlessly integrate ... simple click of a mouse. The point-and-click ...
Medicine Products: