Navigation Links
JCI online early table of contents: June 12, 2008
Date:6/12/2008

link inflammation to obesity-related metabolic diseases

Individuals who are obese are predisposed to a variety of metabolic conditions, including type 2 diabetes. A characteristic of the fat tissue (adipose tissue) of individuals who are obese is that it is inflammed, and understanding the relationship between such inflammation and the onset of the metabolic conditions is of importance in combating what has become a large public health problem. In a new mouse study, Gkhan Hotamisligil and colleagues, at the Harvard School of Public Health, Boston, found that interactions between adipocytes (fat cells) and inflammatory cells called macrophages seem to underlie the inflammation-related metabolic deterioration associated with obesity.

In the study, when adipocytes isolated from mice lacking proteins known as FABPs, which are molecules that govern metabolic and inflammatory responses, were cultured with normal macrophages, the macrophages expressed reduced levels of inflammatory molecules. Likewise, when macrophages isolated from mice lacking FABPs were cultured with normal adipocyes, the adipocytes responded more to insulin and took up more glucose. Similar results, indicating that FABPs from both adipocytes and macrophages contribute to the inflammatory basis for metabolic deterioration, were obtained in vivo. The authors therefore suggest that this FABP-related pathway may be a novel target for metabolism-related disorders.

TITLE: Adipocyte/macrophage fatty acidbinding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice

AUTHOR CONTACT:
Gkhan S. Hotamisligil
Harvard School of Public Health, Boston, Massachusetts, USA.
Phone: (617) 432-1950; Fax: (617) 432-1941; E-mail: ghotamis@hsph.harvard.edu.

View the PDF of this article at: https://www.the-jci.org/
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. A self-help program delivered online can improve insomnia in adults
2. The HealthCentral Network Acquires MedTrackAlert, Extending its Ability to Reach Highly Engaged Online Health Consumers
3. JCI online early table of contents: June 5, 2008
4. Death on the Net? Over 60% of Medicines Sold by Online Pharmacies are Fake
5. Online Directory Lists Anatomical Donation Programs in U.S. Offering Free Cremations
6. Virginia Motor Vehicle Crash Outcomes ONLINE at www.vacodes.org
7. MedTrust Online Collaborates With Oracle and Dell to Provide Oncologists With the Next Generation Tool for Personalized Care Delivery
8. The National Association For Continence and The HealthCentral Network Form Alliance to Develop New Online Resources for Patients Coping with Incontinence
9. Video/Online Games for Health: 12 Research Teams From Across U.S. To Receive Major Grants
10. Real Time, Face-to-Face Doctor Visits Now Available Online
11. MDNG Offers Free Online Discussion With Maverick Physician Jay Parkinson, M.D.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2015)... (PRWEB) May 24, 2015 ... System CEO - The students ... honored at the fourth annual A ... 15 at Geneva National in Lake ... ,     -Badger High School,         Jonathan Alfonso, ...
(Date:5/23/2015)... 23, 2015 With the implementation of ... finding it increasingly difficult to provide their employees with ... provide adequate insurance for employees stand to face strict ... an integral part of a business’s success or failure. ... businesses, Online USA Doctors has created a varying level ...
(Date:5/23/2015)... (PRWEB) May 23, 2015 Javon ... at the Sports Medicine and Rehabilitation Center, 557 N. ... program, Mondays, June 1-July 20, 5:30-6:30 pm. , The ... coach, and Laurie Finke, RN, BSN, who will offer ... education on nutrition, running mechanics and show selection and ...
(Date:5/22/2015)... The American College of Traditional Chinese Medicine ... will hold a webinar on the updates of the ... Classical Chinese Medicine. , Webinar – First Professional Doctorate ... Dean of Clinical Education, will lead this webinar in ... program. ACTCM is currently developing this degree program based ...
(Date:5/22/2015)... Omar Ahmad Barrada, a junior at Milton ... 2015 Congress of Future Medical Leaders in Boston, Mass. ... “America’s highest achieving high school students.” , “I’m excited ... goals and learn better study habits,” said Omar. “The ... we can ask the surgeons questions.” , The goal ...
Breaking Medicine News(10 mins):Health News:Mercy Foundation Honors 16 Students for Making a Difference - Mercy Health System Javon Bea 2Health News:Online USA Doctors Now Offers Cost-Saving Alternative Healthcare for Businesses 2Health News:Online USA Doctors Now Offers Cost-Saving Alternative Healthcare for Businesses 3Health News:ACTCM Announces Upcoming June Events 2Health News:Milton Hershey School Student Chosen for Congress of Future Medical Leaders 2
... , ... medical marketing newsletter Healthcare Success Marketing Advisor has just surpassed the 10,000 subscriber milestone. ... (PRWEB) March ... Healthcare Success Marketing Advisor has just surpassed over 10,000 subscribers., , ,Written and ...
... Accident claims solicitors, First Personal Injury, want to see more advice made readily available to parents and pupils about asbestos exposure in ... , ... , , ... ...
... employees of workplaces nationwide will wear purple to support epilepsy awareness on March 26 . Thousands of Americans will also join the campaign by hosting Purple Day activities in ... ... ... ...
... Kaine released the following statement: , ... , , ... ... (Logo: http://www.newscom.com/cgi-bin/prnh/20080519/DNCLOGO ) , ...
... Participants use an easy online ... Network Solutions® will donate $1 per vote for the winning drawing with all proceeds going to ... Herndon, ... prematurely, and 1 in 10 will end up in a neonatal intensive care unit. Prematurity is ...
... ... in woman,s sportswear. Sofine fitness apparel is made of supplex and allows woman,s workout clothes ... apparel with style and comfort that is long-lasting and won,t fade or peel. Find ... ...
Cached Medicine News:Health News:Medical Marketing Newsletter Reaches 10,000 Subscribers 2Health News:First Personal Injury on Asbestos in Schools 2Health News:Purple Day March 26th: The United States Goes Purple in Support of Epilepsy Awareness 2Health News:Purple Day March 26th: The United States Goes Purple in Support of Epilepsy Awareness 3Health News:DNC Chairman Tim Kaine Praises Historic Passage of Health Insurance Reform 2Health News:DNC Chairman Tim Kaine Praises Historic Passage of Health Insurance Reform 3Health News:Network Solutions Hosts Online Drawing Contest to Support the March of Dimes 2Health News:Network Solutions Hosts Online Drawing Contest to Support the March of Dimes 3Health News:Sofine Fashions Women's Active Wear 2010 Spring Collection 2
(Date:5/22/2015)... May 22, 2015 The leading companies ... billion global cardiac rhythm management device market dominate ... that Medtronic, St. Jude Medical, Boston Scientific and ... this market segment. The healthcare market research publisher,s ... uses 2015 as a base year, providing forecasts ...
(Date:5/22/2015)... 22, 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX), a ... and regeneration, today announced that J.J. Finkelstein , ... a corporate overview at two upcoming investor conferences. ... 4 th Annual Microcap Conference on Thursday May ... at 11:00 am EDT.  A webcast will be ...
(Date:5/22/2015)... YORK and KING OF PRUSSIA, Pa. ... Foundation (NHF) has awarded CSL Behring its ... and unwavering commitment to advancing science and improving the care ... Paul Perreault , CEO and Managing Director, CSL Limited, ... York City on May 21. "The ...
Breaking Medicine Technology:Kalorama: Top Companies Dominate Cardiac Defibrillator Market 2Kalorama: Top Companies Dominate Cardiac Defibrillator Market 3Kalorama: Top Companies Dominate Cardiac Defibrillator Market 4RegeneRx to Present at 2 Investor Conferences 2RegeneRx to Present at 2 Investor Conferences 3National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 2National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 3National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 4
... Medical Corp. (NYSE: CMN ) today reported ... Minntech Corporation subsidiary, sustained serious injuries in a crash ... Mr. Malkin,s condition is currently classified by the ... and recovery, division heads at Minntech will report to ...
... WESTON, Fla., June 6, 2011 American Scientific Resources, ... the Undiscovered Equities Spring Conference held in Boca Raton, ... Steak House, 999 East Camino Real, Boca Raton, FL ... time slots during the all day conference. ...
Cached Medicine Technology:American Scientific Resources Will be a Presenter at the Undiscovered Equities Spring Conference in Boca Raton 2American Scientific Resources Will be a Presenter at the Undiscovered Equities Spring Conference in Boca Raton 3
Straight, 7 mm tying platform. Castroviejo handle. Manufactured in titanium. Overall length 4.2 inches....
Angled 45 degree shafts with 10.5 mm tying platform. 1 mm of tip is crisscross serrated. Serrated handle with dull finish. Most popular size or model. Overall length 3.2 inches....
Titanium. Curved shafts with 5.5 mm tying platform. Round knurled handle with dull finish. Overall length 4.3 inches....
Ultra-fine 5 mm tying platform is valuable when manipulating delicate 10-0 and 11-0 sutures. Pin in handle keeps tips in alignment. Shafts available straight or angled 45 degrees, 8 mm from tip. Stra...
Medicine Products: