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JCI online early table of contents: June 12, 2008
Date:6/12/2008

omas S. Kilduff
SRI International, Menlo Park, California, USA.
Phone: (650) 859-5509; Fax: (650) 859-3153; E-mail: thomas.kilduff@sri.com.

View the PDF of this article at: https://www.the-jci.org/article.php?id=35115


HEMATOLOGY: Tumor cells want no contact with immune cells

As tumors progress they develop ways to escape recognition and attack by cells of the immune system. However, the mechanisms by which tumors modify the immune system have not been clearly determined. New insight into the way in which chronic lymphocytic leukemia (CLL) cells limit immune cell attack has now been provided by John Gribben and colleagues, at Barts and The London School of Medicine, United Kingdom.

For immune cells known as CD4+ and CD8+ T cells to become activated they must contact other cells known as APCs. The area of contact is known as the immunological synapse and it is highly organized. In the study, CD4+ and CD8+ T cells from patients with CLL were found to exhibit defective immunological synapse formation with APCs. Further, if CD4+ and CD8+ T cells from healthy individuals were cultured with CLL APCs, they also showed defective immunological synapse formation. As treatment with an immune systemmodifying drug improved immunological synapse formation, the authors suggest that approaches to overcoming immunological synapse defects might improve the efficacy of new ways to treat cancer that are currently being developed and that are based on enhancing the antitumor activity of CD4+ and CD8+ T cells.

TITLE: Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug

AUTHOR CONTACT:
John G. Gribben
Barts and The London School of Medicine, London, United Kingdom.
Phone: 44-207-882-6126; Fax: 44-207-882-6126;
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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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