Navigation Links
JCI online early table of contents: June 1, 2011
Date:6/1/2011

EDITOR'S PICK: Reducing a severe side effect of a common anticancer drug

Cisplatin is one of the most widely used anticancer chemotherapeutics. However, it has some severe side effects in normal tissues, in particular it is toxic to the kidneys. Understanding the mechanisms underlying this toxicity could identify targets for drugs that could be given together with cisplatin to protect the kidney during chemotherapy. In this context, a team of researchers, led by Zheng Dong, at Georgia Health Sciences University, Augusta, has now identified the signaling protein PKC-delta as a critical regulator of cisplatin-mediated kidney toxicity in mice. Importantly, inhibiting PKC-delta not only protected the kidneys from the toxic effects of cisplatin but also enhanced the antitumor effects of the drug in several xenograft and syngeneic mouse tumor models. The team therefore suggests that targeting PKC-delta could help reduce the severe kidney toxicity that occurs in cancer patients undergoing chemotherapy with cisplatin and other cisplatin-based chemotherapeutics.

TITLE: Inhibition of PKC-delta reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer

AUTHOR CONTACT:
Zheng Dong
Medical College of Georgia and Charlie Norwood VA Medical Center, Augusta, Georgia, USA.
Phone: 706.721.2825; Fax: 706.721.6120; E-mail: zdong@mail.mcg.edu.

View this article at: http://www.jci.org/articles/view/45586?key=93f34735232ae0bf2ab0


ONCOLOGY: Subdivisions reveal effective therapies in triple-negative breast cancer

Breast cancers can be divided into different types based on several criteria, including the marker proteins they express. Treatment of breast cancers lacking expression of the proteins to which hormones bind (so ca
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
2. Web Content Management Enables Government Transparency, Participation, and Collaboration Online
3. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. Pharmahelper Pleased To Recognize Online Pharmacy Practice Standards Announced By Google Adwords
6. Online Dating Reinvents Itself with the Recent Roll-Out of Teacherhookup.com, a Free Website that Focuses on a Person's Career in Education!
7. EdenHome.com Adds Aventura Organic Clothes to Site and Announces Largest Online Selection of Stylish Organic Clothes for Men, Women and Children
8. Fire Protection Online Resolves Safety Concerns with CO2 Fire Extinguishers
9. JCI online early table of contents: Feb. 15, 2010
10. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
11. New Online Store Makes Buying Cosmetics a Healthy Choice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Padre Murphy's and Owner Tom Boyle in Glendale, AZ ... Alliance (PPHA). The PPHA's passion for others' well-being and ... greats, treated for obstructive sleep apnea (OSA) has propelled them ... in the valley. The most recent plans for an event ...
(Date:1/22/2015)... Angelweddingdress is a famous wedding dress company offering many ... it on Facebook, Twitter, and Pinterest. The fans will have ... a lottery every week. , Moreover, the company has extended ... Angelweddingdress homepage for more information. , Angelweddingdress ...
(Date:1/22/2015)... 22, 2015 The federal court overseeing thousands ... District Court, Southern District of West Virginia has upheld a ... proceeding’s first bellwether trial. In an Order dated January 21st, ... after finding that C.R. Bard had not proven a miscarriage ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Thousand of ... Medical Care recalled its GranuFlo and NaturaLyte dialysis concentrates ... underway in U.S. District Court, District of Massachusetts, Bernstein ... 20th, the Court has remanded a case filed by ...
(Date:1/22/2015)... Carinsurancesavings.biz has released a new blog post presenting the basic ... , Purchasing an accidental death and dismemberment rider for a ... rider provides benefits if the insured dies in an accident. ... of life insurance. , AD&D is not expensive and ...
Breaking Medicine News(10 mins):Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2
... Center in Tampa, Fla., have found contrary to ... malignancies to higher body mass index (BMI) that ... was no such link. They concluded that BMI was ... patient survival. Their study was published in the ...
... (HealthDay News) -- The common cold appears to increase ... makes them more sensitive, which triggers coughing, wheezing and ... are especially vulnerable to this virus-induced coughing, said the ... are known as transient receptor potential (TRP) receptors. ...
... valuable as an activity after two months of using ... findings come from a study of 199 middle school ... a reading improvement class that included Amazon,s Kindle e-reader, ... Methodist University, Dallas. The researchers found that boys ...
... the day before a colonoscopy may be just as ... Washington University School of Medicine in St. Louis have ... test by cleansing their colons, doctors often can,t see ... Gastrointestinal Endoscopy , the researchers say that doctors ...
... By Steven Reinberg HealthDay Reporter , ... injections of a novel "monoclonal antibody" lowered LDL cholesterol ... as 72 percent. This new treatment could help ... five people who don,t respond to the commonly prescribed ...
... MONDAY, March 26 (HealthDay News) -- Most people who go to ... but it can take hours or days to make a definitive ... of CT scan given in the emergency room seems to identify ... sent home safely sooner. "You can go to an emergency ...
Cached Medicine News:Health News:Does BMI affect post-surgical complications, survival in esophageal adenocarcinoma? 2Health News:Research Shows How Colds Lead to Coughing, Wheezing 2Health News:Middle school boys who are reluctant readers value reading more after using e-readers 2Health News:Middle school boys who are reluctant readers value reading more after using e-readers 3Health News:Poor colonoscopy prep hides pre-cancerous polyps 2Health News:Poor colonoscopy prep hides pre-cancerous polyps 3Health News:Poor colonoscopy prep hides pre-cancerous polyps 4Health News:New Injection Might Lower Tough-to-Treat Cholesterol 2Health News:New Injection Might Lower Tough-to-Treat Cholesterol 3Health News:CT Scans Can Spot Heart Trouble Fast 2Health News:CT Scans Can Spot Heart Trouble Fast 3
(Date:1/23/2015)... and Markets ( http://www.researchandmarkets.com/research/vzhr6h/video ) has announced the ... Size, Share, Growth, Trends and Forecast 2014 - 2020" ... the topic of fascination since the era of the cold ... the Soviet Russia. Earlier even a small glimpse of human ...
(Date:1/23/2015)... 23, 2015 Research and Markets ( http://www.researchandmarkets.com/research/5dh22x/urinary_catheters ... Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and ... Size, Share, Growth, Trends and Forecast 2014 - 2020" ... At present, the global market for urinary catheters is ...
(Date:1/23/2015)...  A new analysis of Centers for Medicare and Medicaid ... that 81 percent of seniors chose lower-cost preferred pharmacy ... certain pharmacies. The findings were released by Drug ... the foundation of Medicare Part D," said Pharmaceutical Care ...
Breaking Medicine Technology:Video Telemedicine Market- Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Video Telemedicine Market- Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3New Analysis: 81 Percent of Medicare Part D Seniors Choose "Preferred Pharmacy" Plans in 2015 2
... Oct. 19, 2011 Reportlinker.com announces that a ... its catalogue: Byetta (Type ... 2020 http://www.reportlinker.com/p0657148/Byetta-Type-2-Diabetes-–-Analysis-and-Forecasts-to-2020.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Pathology ... Analysis and Forecasts to 2020 ...
... IRIDEX Corporation (Nasdaq: IRIX ) announced today ... an optional MicroPulse module in the Company,s IQ532 (green) ... infrared, yellow and green laser systems which can deliver ... a green wavelength have been our highest selling laser ...
Cached Medicine Technology:Byetta (Type 2 Diabetes) - Analysis and Forecasts to 2020 2Byetta (Type 2 Diabetes) - Analysis and Forecasts to 2020 3Byetta (Type 2 Diabetes) - Analysis and Forecasts to 2020 4Byetta (Type 2 Diabetes) - Analysis and Forecasts to 2020 5Byetta (Type 2 Diabetes) - Analysis and Forecasts to 2020 6IRIDEX Launches New MicroPulse™ Module Targeting the Broad Ophthalmology Laser Photocoagulation Market 2IRIDEX Launches New MicroPulse™ Module Targeting the Broad Ophthalmology Laser Photocoagulation Market 3
... Eppendorf Reference Series 2000 Pipette is a ... a compact and robust design, and superior ... used to operate the measuring stroke and ... Product features: Eppendorf "pipette/tip" system ...
... The AlphaPette Pipettor is the ... beyond. Offers accuracy, comfort, and reliability. ... digital volume readout sub-micrometer. Easy interchangeable ... or tiny hands. Adjustable rapid pipet ...
... The new Finnpipette Focus from Thermo ... with uncompromising performance. Advanced features such ... .01ul fine volume adjustment on microvolumes help ... in single channel pipettes. The new interchangeable ...
... and value!, Comfortable feel and ... contoured handle , Finer control while ... action , Completely autoclavable for easy ... for recalibration , Easy-to-read precision micrometer ...
Medicine Products: