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JCI online early table of contents: July 18, 2011
Date:7/18/2011

mouse muscle that does not involve IL-15. Specifically, the team found that IL-15R-alpha is important for defining the type of muscle fibers in skeletal muscle. In its absence, the muscles in mice did not tire as easily and the mice could exercise more extensively than normal mice. These data were then shown to be relevant to humans, as the team found that specific variants at a given region of the IL15RA gene occurred with differing frequencies among groups of elite athletes doing different endurance sports.

TITLE: Loss of IL-15 receptor-alpha alters the endurance, fatigability, and metabolic characteristics of mouse fast skeletal muscles

AUTHOR CONTACT:
Tejvir S. Khurana
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Phone: 215.573.2640; Fax: 215.573.5851; E-mail: tsk@mail.med.upenn.edu.

View this article at: http://www.jci.org/articles/view/44945?key=31dbc05d658ee21877d7


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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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