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JCI online early table of contents: July 18, 2011
Date:7/18/2011

raduate School of Medicine, Tokyo, Japan.
Phone: 81.3.5800.9735; Fax: 81.3.5800.9736; E-mail: fujita-dis@h.u-tokyo.ac.jp.

View this article at: http://www.jci.org/articles/view/43124?key=c110164a3d2663b8be40


VASCULAR DISEASE: New cause of blood vessel abnormalities identified

Hereditary hemorrhagic telangiectasia is a genetic disorder that results in the development of abnormalities in the blood vessels in organs such as the lungs, intestines, and brain. These abnormalities are known as arteriovenous malformations and they are associated with a high risk of potentially devastating bleeding episodes. New data, generated in mice, by Kristina I. Bostrm, Yucheng Yao, and colleagues, at the David Geffen School of Medicine, Los Angeles, suggests that deficiency of the protein MGP could be a previously unknown cause of AVMs. The authors therefore suggest that abnormalities in MGP function could contribute to the triggering of AVMs in individuals with hereditary hemorrhagic telangiectasia.

TITLE: Matrix Gla protein deficiency causes arteriovenous malformations in mice

AUTHOR CONTACT:
Kristina I. Bostrm
David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Phone: 310.794.4417; Fax: 310.206.8553; E-mail: kbostrom@mednet.ucla.edu.

Yucheng Yao
David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Phone: 310.794.4417; Fax: 310.206.8553; E-mail: yyao@mednet.ucla.edu.

View this article at: http://www.jci.org/articles/view/57567?key=b4ad3ef6c0ce89322950


VASCULAR BIO
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Contact: Karen Honey
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Journal of Clinical Investigation
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