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JCI online early table of contents: July 18, 2011
Date:7/18/2011

known as osteoblasts. Further analysis revealed cell-intrinsic defects in both osteoblasts and osteoclasts in vivo and in vitro and determined the underlying molecular mechanism. These data indicate that 3BP2 has a key role in maintaining normal bone composition because it is essential for the normal function of both osteoblasts and osteoclasts.

TITLE: 3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions

AUTHOR CONTACT:
Robert Rottapel
University Health Network, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Phone: 416.581.7852; Fax: 416.595.5719; E-mail: rottapel@uhnres.utoronto.ca.

View this article at: http://www.jci.org/articles/view/45843?key=b8ee27a90a54c7b364bc


PULMONARY: Home for progenitor cells modified in cystic fibrosis airways

Individuals with cystic fibrosis (CF) suffer persistent bacterial infections of the lungs as a result of impaired secretion of mucus from glands in the airways known as submucosal glands. These glands are also home to slow-cycling progenitor cells, which are thought to be involved in repairing CF airways damaged by the persistent bacterial infections. A team of researchers, led by John Engelhardt, at The University of Iowa Carver College of Medicine, Iowa City, has now identified a role for the protein CGRP in regulating both mucus secretion from submucosal glands and their ability to house slow-cycling progenitor cells.

Mucus secretion stimulated by CGRP is impaired in individuals with CF. Therefore, submucosal glands respond by producing more and more CGRP. Consistent with this, Engelhardt and colleagues found that signaling downstream of CGRP was hyperactivated in CF human, pig, ferret, and mouse submucosal glands. In turn, the increased levels of CGRP p
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